| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 12,950,075 | 501,168,000 | 15.16% | ||
| 2 | VANGUARD GROUP INC | 6,442,210 | 249,314,000 | 7.54% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 5,980,163 | 231,432,000 | 7.00% | ||
| 4 | PERCEPTIVE ADVISORS LLC | 3,316,523 | 128,349,000 | 3.88% | ||
| 5 | BB BIOTECH AG | 3,151,552 | 121,965,000 | 3.69% | ||
| 6 | Invesco Ltd. | 2,781,423 | 107,642,000 | 3.26% | ||
| 7 | FRANKLIN RESOURCES INC | 2,409,715 | 93,256,000 | 2.82% | ||
| 8 | JANUS HENDERSON INVESTORS US LLC | 2,356,485 | 91,203,000 | 2.76% | ||
| 9 | STATE STREET CORP | 2,289,171 | 88,571,000 | 2.68% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 2,266,340 | 87,707,000 | 2.65% | ||
| 11 | ORBIMED ADVISORS LLC | 2,128,774 | 82,384,000 | 2.49% | ||
| 12 | BlackRock Fund Advisors | 2,118,355 | 81,980,000 | 2.48% | ||
| 13 | Bank of New York Mellon Corp | 1,400,813 | 54,212,000 | 1.64% | ||
| 14 | WESTFIELD CAPITAL MANAGEMENT CO LP | 1,393,505 | 53,929,000 | 1.63% | ||
| 15 | MILLENNIUM MANAGEMENT LLC | 1,335,798 | 51,695,000 | 1.56% | ||
| 16 | Capital World Investors | 1,188,000 | 45,976,000 | 1.39% | ||
| 17 | ALLIANCEBERNSTEIN L.P. | 1,023,442 | 39,607,000 | 1.20% | ||
| 18 | HealthCor Management, L.P. | 988,900 | 38,270,000 | 1.16% | ||
| 19 | JPMORGAN CHASE & CO | 962,745 | 37,259,000 | 1.13% | ||
| 20 | OppenheimerFunds, Inc. | 901,538 | 34,890,000 | 1.06% | ||
| 21 | NORGES BANK | 898,654 | 34,777,000 | 1.05% | ||
| 22 | BAKER BROS. ADVISORS LP | 895,422 | 34,653,000 | 1.05% | ||
| 23 | ArrowMark Colorado Holdings LLC | 891,527 | 34,502,000 | 1.04% | ||
| 24 | Senator Investment Group LP | 875,000 | 33,862,000 | 1.02% | ||
| 25 | DEUTSCHE BANK AG\ | 848,185 | 32,822,000 | 0.99% | ||
| 26 | PICTET ASSET MANAGEMENT LTD | 781,737 | 30,253,000 | 0.92% | ||
| 27 | GREAT POINT PARTNERS LLC | 750,000 | 29,025,000 | 0.88% | ||
| 28 | SECTORAL ASSET MANAGEMENT INC | 748,988 | 28,986,000 | 0.88% | ||
| 29 | GOLDMAN SACHS GROUP INC | 746,515 | 28,890,000 | 0.87% | ||
| 30 | FIRST TRUST ADVISORS LP | 678,210 | 26,247,000 | 0.79% | ||
| 31 | Alyeska Investment Group, L.P. | 645,536 | 24,982,000 | 0.76% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 634,571 | 24,557,000 | 0.74% | ||
| 33 | MACQUARIE GROUP LTD | 632,065 | 24,461,000 | 0.74% | ||
| 34 | BLACKROCK ADVISORS LLC | 616,972 | 23,877,000 | 0.72% | ||
| 35 | Polar Capital LLP | 597,256 | 23,114,000 | 0.70% | ||
| 36 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 578,134 | 22,374,000 | 0.68% | ||
| 37 | Avoro Capital Advisors LLC | 541,000 | 20,937,000 | 0.63% | ||
| 38 | TimesSquare Capital Management, LLC | 531,100 | 20,554,000 | 0.62% | ||
| 39 | NORTHERN TRUST CORP | 457,583 | 17,708,000 | 0.54% | ||
| 40 | Rock Springs Capital Management LP | 410,000 | 15,867,000 | 0.48% | ||
| 41 | Tekla Capital Management LLC | 391,869 | 15,165,000 | 0.46% | ||
| 42 | BROWN ADVISORY INC | 379,611 | 14,691,000 | 0.44% | ||
| 43 | JENNISON ASSOCIATES LLC | 369,409 | 14,296,000 | 0.43% | ||
| 44 | WELLINGTON MANAGEMENT GROUP LLP | 367,867 | 14,236,000 | 0.43% | ||
| 45 | Cormorant Asset Management, LP | 359,000 | 13,893,000 | 0.42% | ||
| 46 | MARSHALL WACE, LLP | 351,582 | 13,607,000 | 0.41% | ||
| 47 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 319,661 | 12,371,000 | 0.37% | ||
| 48 | Neuberger Berman Group LLC | 319,083 | 12,349,000 | 0.37% | ||
| 49 | EMERALD ADVISERS, LLC | 314,647 | 12,177,000 | 0.37% | ||
| 50 | AMERICAN CENTURY COMPANIES INC | 310,235 | 12,006,000 | 0.36% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
