| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 13,001,802 | 658,412,000 | 15.07% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 9,364,314 | 474,209,000 | 10.85% | ||
| 3 | VANGUARD GROUP INC | 6,288,257 | 318,437,000 | 7.29% | ||
| 4 | BB BIOTECH AG | 3,121,552 | 158,075,000 | 3.62% | ||
| 5 | Invesco Ltd. | 2,596,641 | 131,494,000 | 3.01% | ||
| 6 | PERCEPTIVE ADVISORS LLC | 2,476,272 | 125,398,000 | 2.87% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 2,150,949 | 108,924,000 | 2.49% | ||
| 8 | STATE STREET CORP | 2,143,468 | 108,544,000 | 2.48% | ||
| 9 | JANUS HENDERSON INVESTORS US LLC | 2,131,579 | 107,943,000 | 2.47% | ||
| 10 | FRANKLIN RESOURCES INC | 2,012,286 | 101,902,000 | 2.33% | ||
| 11 | BlackRock Fund Advisors | 2,009,633 | 101,768,000 | 2.33% | ||
| 12 | ORBIMED ADVISORS LLC | 1,815,474 | 91,936,000 | 2.10% | ||
| 13 | Capital World Investors | 1,481,000 | 74,998,000 | 1.72% | ||
| 14 | Bank of New York Mellon Corp | 1,406,038 | 71,202,000 | 1.63% | ||
| 15 | WESTFIELD CAPITAL MANAGEMENT CO LP | 1,255,995 | 63,604,000 | 1.46% | ||
| 16 | Senator Investment Group LP | 1,150,000 | 58,236,000 | 1.33% | ||
| 17 | CITADEL ADVISORS LLC | 1,037,519 | 52,540,000 | 1.20% | ||
| 18 | DEUTSCHE BANK AG\ | 1,023,195 | 51,813,000 | 1.19% | ||
| 19 | JPMORGAN CHASE & CO | 1,012,428 | 51,270,000 | 1.17% | ||
| 20 | OppenheimerFunds, Inc. | 1,002,548 | 50,769,000 | 1.16% | ||
| 21 | BLACKROCK ADVISORS LLC | 943,190 | 47,763,000 | 1.09% | ||
| 22 | EAGLE ASSET MANAGEMENT INC | 914,500 | 46,310,000 | 1.06% | ||
| 23 | MACQUARIE GROUP LTD | 905,748 | 45,867,000 | 1.05% | ||
| 24 | BAKER BROS. ADVISORS LP | 895,422 | 45,344,000 | 1.04% | ||
| 25 | AMERICAN CENTURY COMPANIES INC | 880,507 | 44,589,000 | 1.02% | ||
| 26 | ALLIANCEBERNSTEIN L.P. | 876,049 | 44,363,000 | 1.02% | ||
| 27 | NORGES BANK | 898,654 | 43,465,000 | 0.99% | ||
| 28 | ArrowMark Colorado Holdings LLC | 813,127 | 41,177,000 | 0.94% | ||
| 29 | SECTORAL ASSET MANAGEMENT INC | 802,979 | 40,663,000 | 0.93% | ||
| 30 | GOLDMAN SACHS GROUP INC | 721,896 | 36,557,000 | 0.84% | ||
| 31 | PICTET ASSET MANAGEMENT LTD | 696,378 | 35,265,000 | 0.81% | ||
| 32 | Tekla Capital Management LLC | 656,622 | 33,251,000 | 0.76% | ||
| 33 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 599,623 | 30,364,000 | 0.69% | ||
| 34 | FIRST TRUST ADVISORS LP | 585,622 | 29,656,000 | 0.68% | ||
| 35 | GEODE CAPITAL MANAGEMENT, LLC | 582,339 | 29,489,000 | 0.67% | ||
| 36 | TimesSquare Capital Management, LLC | 503,300 | 25,487,000 | 0.58% | ||
| 37 | NORTHERN TRUST CORP | 502,209 | 25,432,000 | 0.58% | ||
| 38 | Avoro Capital Advisors LLC | 490,582 | 24,843,000 | 0.57% | ||
| 39 | Alyeska Investment Group, L.P. | 441,235 | 22,344,000 | 0.51% | ||
| 40 | Rock Springs Capital Management LP | 410,000 | 20,762,000 | 0.48% | ||
| 41 | Cormorant Asset Management, LP | 398,301 | 20,170,000 | 0.46% | ||
| 42 | GREAT POINT PARTNERS LLC | 394,080 | 19,956,000 | 0.46% | ||
| 43 | JENNISON ASSOCIATES LLC | 368,156 | 18,643,000 | 0.43% | ||
| 44 | BROWN ADVISORY INC | 347,270 | 17,585,000 | 0.40% | ||
| 45 | WELLINGTON MANAGEMENT GROUP LLP | 346,538 | 17,549,000 | 0.40% | ||
| 46 | LORD, ABBETT & CO. LLC | 345,748 | 17,509,000 | 0.40% | ||
| 47 | Polar Capital LLP | 337,606 | 17,096,000 | 0.39% | ||
| 48 | BlackRock Group LTD | 298,529 | 15,117,000 | 0.35% | ||
| 49 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 296,121 | 14,996,000 | 0.34% | ||
| 50 | EMERALD MUTUAL FUND ADVISERS TRUST | 284,790 | 14,422,000 | 0.33% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
