| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PRIMECAP MANAGEMENT CO/CA/ | 5,553,600 | 18,493,000 | 28.19% | ||
| 2 | BVF INC/IL | 4,400,289 | 14,653,000 | 22.34% | ||
| 3 | ADAMS STREET PARTNERS LLC | 1,839,730 | 6,126,000 | 9.34% | ||
| 4 | VANGUARD GROUP INC | 995,646 | 3,315,000 | 5.05% | ||
| 5 | AMERIPRISE FINANCIAL INC | 966,995 | 3,221,000 | 4.91% | ||
| 6 | BlackRock Finance, Inc. | 781,773 | 2,603,000 | 3.97% | ||
| 7 | Alyeska Investment Group, L.P. | 512,563 | 1,707,000 | 2.60% | ||
| 8 | Cannell & Co. | 407,741 | 1,358,000 | 2.07% | ||
| 9 | Iguana Healthcare Management, LLC | 400,000 | 1,332,000 | 2.03% | ||
| 10 | RENAISSANCE TECHNOLOGIES LLC | 369,596 | 1,231,000 | 1.88% | ||
| 11 | DISCIPLINED GROWTH INVESTORS INC /MN | 329,100 | 1,096,000 | 1.67% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 282,665 | 941,000 | 1.43% | ||
| 13 | First Eagle Investment Management, LLC | 219,420 | 731,000 | 1.11% | ||
| 14 | Candriam S.C.A. | 214,000 | 713,000 | 1.09% | ||
| 15 | NORGES BANK | 182,357 | 607,000 | 0.93% | ||
| 16 | GOLDMAN SACHS GROUP INC | 170,439 | 568,000 | 0.87% | ||
| 17 | MARSHALL WACE NORTH AMERICA, L.P. | 187,088 | 561,000 | 0.86% | ||
| 18 | BANK OF AMERICA CORP /DE/ | 158,578 | 528,000 | 0.81% | ||
| 19 | TWO SIGMA INVESTMENTS, LP | 131,867 | 439,000 | 0.67% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 124,569 | 414,000 | 0.63% | ||
| 21 | ELEMENT CAPITAL MANAGEMENT LLC | 91,059 | 303,000 | 0.46% | ||
| 22 | Walleye Trading LLC | 88,826 | 296,000 | 0.45% | ||
| 23 | AXA S.A. | 88,700 | 295,000 | 0.45% | ||
| 24 | JPMORGAN CHASE & CO | 83,345 | 277,000 | 0.42% | ||
| 25 | Paloma Partners Management Co | 78,350 | 261,000 | 0.40% | ||
| 26 | NORTHERN TRUST CORP | 76,373 | 255,000 | 0.39% | ||
| 27 | Connor, Clark & Lunn Investment Management Ltd. | 70,100 | 233,000 | 0.36% | ||
| 28 | BARCLAYS PLC | 66,661 | 222,000 | 0.34% | ||
| 29 | LMR Partners LLP | 60,347 | 201,000 | 0.31% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 59,700 | 199,000 | 0.30% | Put | |
| 31 | A.R.T. Advisors, LLC | 59,360 | 197,000 | 0.30% | ||
| 32 | D. E. Shaw & Co., Inc. | 55,467 | 185,000 | 0.28% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 53,124 | 177,000 | 0.27% | ||
| 34 | NJ State Employees Deferred Compensation Plan | 48,000 | 160,000 | 0.24% | ||
| 35 | CITADEL ADVISORS LLC | 45,997 | 154,000 | 0.23% | ||
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 46,012 | 154,000 | 0.23% | ||
| 37 | CREDIT SUISSE AG/ | 44,484 | 149,000 | 0.23% | ||
| 38 | GLENMEDE TRUST CO NA | 12,900 | 118,000 | 0.18% | ||
| 39 | Birchview Capital, LP | 28,689 | 96,000 | 0.15% | SH | |
| 40 | MORGAN STANLEY | 28,579 | 95,000 | 0.14% | ||
| 41 | TURNER INVESTMENTS LLC | 24,783 | 83,000 | 0.13% | ||
| 42 | ZACKS INVESTMENT MANAGEMENT | 23,997 | 80,000 | 0.12% | ||
| 43 | Bank of New York Mellon Corp | 23,539 | 78,000 | 0.12% | ||
| 44 | Virtu KCG Holdings LLC | 23,125 | 77,000 | 0.12% | ||
| 45 | TUDOR INVESTMENT CORP ET AL | 22,900 | 76,000 | 0.12% | ||
| 46 | Squarepoint Ops LLC | 19,251 | 64,000 | 0.10% | ||
| 47 | ProShare Advisors LLC | 19,312 | 64,000 | 0.10% | ||
| 48 | DEUTSCHE BANK AG\ | 19,396 | 63,000 | 0.10% | ||
| 49 | STATE STREET CORP | 13,100 | 44,000 | 0.07% | ||
| 50 | BAIRD FINANCIAL GROUP, INC. | 12,000 | 40,000 | 0.06% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
