| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Polar Capital LLP | 2,055,369 | 31,836,000 | 13.88% | ||
| 2 | Redmile Group, LLC | 2,004,849 | 31,055,000 | 13.54% | ||
| 3 | Invesco Ltd. | 1,783,979 | 27,634,000 | 12.04% | ||
| 4 | BlackRock Finance, Inc. | 1,003,407 | 15,543,000 | 6.77% | ||
| 5 | Alyeska Investment Group, L.P. | 952,469 | 14,754,000 | 6.43% | ||
| 6 | AXA S.A. | 917,468 | 14,212,000 | 6.19% | ||
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | 786,127 | 12,177,000 | 5.31% | ||
| 8 | DEERFIELD MANAGEMENT COMPANY, L.P. | 616,508 | 9,550,000 | 4.16% | ||
| 9 | Cortina Asset Management, LLC | 546,810 | 8,470,000 | 3.69% | ||
| 10 | Clarus Ventures, LLC | 445,093 | 6,895,000 | 3.01% | ||
| 11 | Fosun International Ltd | 409,046 | 6,336,000 | 2.76% | ||
| 12 | STATE STREET CORP | 397,830 | 6,163,000 | 2.69% | ||
| 13 | RENAISSANCE TECHNOLOGIES LLC | 363,300 | 5,628,000 | 2.45% | ||
| 14 | WASATCH ADVISORS LP | 315,677 | 4,890,000 | 2.13% | ||
| 15 | Granahan Investment Management, LLC | 295,477 | 4,577,000 | 1.99% | ||
| 16 | WADDELL & REED FINANCIAL INC | 222,200 | 3,442,000 | 1.50% | ||
| 17 | NORTHERN TRUST CORP | 203,324 | 3,149,000 | 1.37% | ||
| 18 | Penn Capital Management Company, LLC | 118,335 | 1,833,000 | 0.80% | ||
| 19 | ESSEX INVESTMENT MANAGEMENT CO LLC | 110,560 | 1,713,000 | 0.75% | ||
| 20 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 103,250 | 1,599,000 | 0.70% | ||
| 21 | TWO SIGMA INVESTMENTS, LP | 89,087 | 1,380,000 | 0.60% | ||
| 22 | DEUTSCHE BANK AG\ | 72,774 | 1,125,000 | 0.49% | ||
| 23 | TIAA CREF INVESTMENT MANAGEMENT LLC | 71,254 | 1,104,000 | 0.48% | ||
| 24 | WELLS FARGO & COMPANY/MN | 65,937 | 1,021,000 | 0.45% | ||
| 25 | VANGUARD GROUP INC | 65,536 | 1,015,000 | 0.44% | ||
| 26 | KORNITZER CAPITAL MANAGEMENT INC /KS | 60,300 | 934,000 | 0.41% | ||
| 27 | D. E. Shaw & Co., Inc. | 57,917 | 897,000 | 0.39% | ||
| 28 | Bank of New York Mellon Corp | 55,131 | 854,000 | 0.37% | ||
| 29 | MILLENNIUM MANAGEMENT LLC | 53,308 | 826,000 | 0.36% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 49,127 | 760,000 | 0.33% | ||
| 31 | TEACHERS ADVISORS, LLC | 46,200 | 716,000 | 0.31% | ||
| 32 | KEYBANK NATIONAL ASSOCIATION/OH | 45,980 | 712,000 | 0.31% | ||
| 33 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 43,746 | 678,000 | 0.30% | ||
| 34 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 40,500 | 628,000 | 0.27% | ||
| 35 | GOLDMAN SACHS GROUP INC | 35,678 | 553,000 | 0.24% | ||
| 36 | DENVER INVESTMENT ADVISORS LLC | 30,880 | 478,000 | 0.21% | ||
| 37 | JPMORGAN CHASE & CO | 30,468 | 472,000 | 0.21% | ||
| 38 | ARDSLEY ADVISORY PARTNERS LP | 30,000 | 465,000 | 0.20% | ||
| 39 | MORGAN STANLEY | 29,176 | 452,000 | 0.20% | ||
| 40 | RHUMBLINE ADVISERS | 22,447 | 348,000 | 0.15% | ||
| 41 | NEW YORK STATE COMMON RETIREMENT FUND | 22,301 | 345,000 | 0.15% | ||
| 42 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 17,131 | 265,000 | 0.12% | ||
| 43 | PRELUDE CAPITAL MANAGEMENT, LLC | 15,637 | 242,000 | 0.11% | ||
| 44 | TFS CAPITAL LLC | 14,125 | 219,000 | 0.10% | ||
| 45 | Nationwide Fund Advisors | 13,765 | 213,000 | 0.09% | ||
| 46 | AMERICAN INTERNATIONAL GROUP, INC. | 13,668 | 212,000 | 0.09% | ||
| 47 | VOYA INVESTMENT MANAGEMENT LLC | 11,500 | 178,000 | 0.08% | ||
| 48 | BANK OF MONTREAL /CAN/ | 11,458 | 178,000 | 0.08% | ||
| 49 | D.A. DAVIDSON & CO. | 11,106 | 172,000 | 0.07% | ||
| 50 | A.R.T. Advisors, LLC | 10,022 | 155,000 | 0.07% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
