| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 22,472,229 | 859,562,000 | 17.55% | ||
| 2 | FMR LLC | 18,471,787 | 706,546,000 | 14.43% | ||
| 3 | BAILLIE GIFFORD & CO | 13,076,781 | 500,187,000 | 10.21% | ||
| 4 | PRIMECAP MANAGEMENT CO/CA/ | 10,895,800 | 416,764,000 | 8.51% | ||
| 5 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 6,610,000 | 252,832,000 | 5.16% | ||
| 6 | VANGUARD GROUP INC | 6,219,143 | 237,882,000 | 4.86% | ||
| 7 | CAPITAL GUARDIAN TRUST CO | 5,175,692 | 197,970,000 | 4.04% | ||
| 8 | WASATCH ADVISORS LP | 2,843,347 | 108,758,000 | 2.22% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 2,669,312 | 102,101,000 | 2.08% | ||
| 10 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,532,789 | 96,879,000 | 1.98% | ||
| 11 | WELLINGTON MANAGEMENT GROUP LLP | 2,382,028 | 91,114,000 | 1.86% | ||
| 12 | BlackRock Fund Advisors | 2,235,048 | 85,491,000 | 1.75% | ||
| 13 | Capital International Investors | 1,769,000 | 67,664,000 | 1.38% | ||
| 14 | STATE STREET CORP | 1,562,703 | 59,777,000 | 1.22% | ||
| 15 | BLACKROCK ADVISORS LLC | 1,424,197 | 54,476,000 | 1.11% | ||
| 16 | OppenheimerFunds, Inc. | 1,400,000 | 53,550,000 | 1.09% | ||
| 17 | PINNACLE ASSOCIATES LTD | 1,356,616 | 51,891,000 | 1.06% | ||
| 18 | EAGLE ASSET MANAGEMENT INC | 1,246,667 | 47,685,000 | 0.97% | ||
| 19 | Invesco Ltd. | 1,244,522 | 47,603,000 | 0.97% | ||
| 20 | USS Investment Management Ltd | 1,203,291 | 46,026,000 | 0.94% | ||
| 21 | MORGAN STANLEY | 1,045,895 | 40,006,000 | 0.82% | ||
| 22 | ROCKEFELLER FINANCIAL SERVICES INC | 915,653 | 35,023,000 | 0.72% | ||
| 23 | DEUTSCHE BANK AG\ | 906,446 | 34,668,000 | 0.71% | ||
| 24 | Mitsubishi UFJ Trust & Banking Corp | 808,600 | 30,929,000 | 0.63% | ||
| 25 | NORGES BANK | 806,985 | 30,867,000 | 0.63% | ||
| 26 | FEDERATED HERMES, INC. | 716,150 | 27,392,000 | 0.56% | ||
| 27 | BlackRock Group LTD | 632,837 | 24,206,000 | 0.49% | ||
| 28 | SECTORAL ASSET MANAGEMENT INC | 612,219 | 23,417,000 | 0.48% | ||
| 29 | BLAIR WILLIAM & CO/IL | 603,182 | 23,071,000 | 0.47% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 574,841 | 21,987,000 | 0.45% | ||
| 31 | Capital International Sarl | 525,400 | 20,097,000 | 0.41% | ||
| 32 | BANK OF AMERICA CORP /DE/ | 524,300 | 20,054,000 | 0.41% | ||
| 33 | NORTHERN TRUST CORP | 512,463 | 19,601,000 | 0.40% | ||
| 34 | CAPITAL INTERNATIONAL LTD /CA/ | 462,100 | 17,675,000 | 0.36% | ||
| 35 | BROWN ADVISORY INC | 460,677 | 17,622,000 | 0.36% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 435,100 | 16,643,000 | 0.34% | Put | |
| 37 | Bank of New York Mellon Corp | 408,304 | 15,617,000 | 0.32% | ||
| 38 | MANNING & NAPIER ADVISORS LLC | 399,490 | 15,279,000 | 0.31% | ||
| 39 | Capital World Investors | 372,000 | 14,229,000 | 0.29% | ||
| 40 | FIRST TRUST ADVISORS LP | 371,550 | 14,212,000 | 0.29% | ||
| 41 | TIAA CREF INVESTMENT MANAGEMENT LLC | 327,273 | 12,518,000 | 0.26% | ||
| 42 | Capital International, Inc./CA/ | 313,000 | 11,972,000 | 0.24% | ||
| 43 | AXA S.A. | 310,397 | 11,873,000 | 0.24% | ||
| 44 | MACQUARIE GROUP LTD | 308,335 | 11,794,000 | 0.24% | ||
| 45 | SPHERA FUNDS MANAGEMENT LTD. | 297,800 | 11,391,000 | 0.23% | ||
| 46 | COMMONWEALTH BANK OF AUSTRALIA | 296,209 | 11,329,000 | 0.23% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 288,600 | 11,039,000 | 0.23% | Call | |
| 48 | BlackRock Finance, Inc. | 270,306 | 10,340,000 | 0.21% | ||
| 49 | GOLDMAN SACHS GROUP INC | 264,309 | 10,110,000 | 0.21% | ||
| 50 | STATE FARM MUTUAL AUTOMOBILE INSURANCE CO | 233,500 | 8,931,000 | 0.18% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
