| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 27,861,720 | 895,197,000 | 21.77% | ||
| 2 | FMR LLC | 18,583,562 | 597,090,000 | 14.52% | ||
| 3 | BAILLIE GIFFORD & CO | 15,238,601 | 489,617,000 | 11.91% | ||
| 4 | PRIMECAP MANAGEMENT CO/CA/ | 11,178,050 | 359,151,000 | 8.73% | ||
| 5 | VANGUARD GROUP INC | 6,165,667 | 198,102,000 | 4.82% | ||
| 6 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 4,474,100 | 143,753,000 | 3.50% | ||
| 7 | WASATCH ADVISORS LP | 3,574,655 | 114,854,000 | 2.79% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 2,516,876 | 80,867,000 | 1.97% | ||
| 9 | BlackRock Fund Advisors | 2,288,741 | 73,537,000 | 1.79% | ||
| 10 | FIRST TRUST ADVISORS LP | 1,794,046 | 57,643,000 | 1.40% | ||
| 11 | STATE STREET CORP | 1,687,104 | 54,204,000 | 1.32% | ||
| 12 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,487,354 | 47,789,000 | 1.16% | ||
| 13 | MORGAN STANLEY | 1,421,587 | 45,674,000 | 1.11% | ||
| 14 | OppenheimerFunds, Inc. | 1,400,000 | 44,982,000 | 1.09% | ||
| 15 | PINNACLE ASSOCIATES LTD | 1,370,706 | 44,041,000 | 1.07% | ||
| 16 | EAGLE ASSET MANAGEMENT INC | 1,344,297 | 43,192,000 | 1.05% | ||
| 17 | Invesco Ltd. | 1,325,748 | 42,596,000 | 1.04% | ||
| 18 | CITADEL ADVISORS LLC | 1,179,981 | 37,913,000 | 0.92% | ||
| 19 | SECTORAL ASSET MANAGEMENT INC | 1,104,075 | 35,474,000 | 0.86% | ||
| 20 | Redmile Group, LLC | 983,966 | 31,615,000 | 0.77% | ||
| 21 | CAPITAL GUARDIAN TRUST CO | 1,002,778 | 31,247,000 | 0.76% | ||
| 22 | NORGES BANK | 948,636 | 30,480,000 | 0.74% | ||
| 23 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 907,697 | 29,164,000 | 0.71% | ||
| 24 | Mitsubishi UFJ Trust & Banking Corp | 809,610 | 26,013,000 | 0.63% | ||
| 25 | MILLENNIUM MANAGEMENT LLC | 800,479 | 25,719,000 | 0.63% | ||
| 26 | ASCEND CAPITAL, LLC | 750,000 | 24,098,000 | 0.59% | ||
| 27 | DEUTSCHE BANK AG\ | 688,791 | 22,128,000 | 0.54% | ||
| 28 | BLAIR WILLIAM & CO/IL | 628,452 | 20,192,000 | 0.49% | ||
| 29 | WELLINGTON MANAGEMENT GROUP LLP | 609,562 | 19,585,000 | 0.48% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 555,125 | 17,835,000 | 0.43% | ||
| 31 | Lagoda Investment Management, L.P. | 545,426 | 17,525,000 | 0.43% | ||
| 32 | GOLDMAN SACHS GROUP INC | 503,694 | 16,184,000 | 0.39% | ||
| 33 | MANNING & NAPIER ADVISORS LLC | 485,810 | 15,608,000 | 0.38% | ||
| 34 | FEDERATED HERMES, INC. | 446,950 | 14,360,000 | 0.35% | ||
| 35 | NORTHERN TRUST CORP | 416,751 | 13,391,000 | 0.33% | ||
| 36 | BANK OF AMERICA CORP /DE/ | 404,500 | 12,996,000 | 0.32% | ||
| 37 | Bank of New York Mellon Corp | 380,277 | 12,219,000 | 0.30% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 357,100 | 11,474,000 | 0.28% | Put | |
| 39 | AXA S.A. | 350,575 | 11,264,000 | 0.27% | ||
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 339,119 | 10,896,000 | 0.26% | ||
| 41 | TIAA CREF INVESTMENT MANAGEMENT LLC | 319,760 | 10,274,000 | 0.25% | ||
| 42 | JACOBS LEVY EQUITY MANAGEMENT, INC | 307,800 | 9,890,000 | 0.24% | ||
| 43 | Jupiter Investment Management Ltd | 294,400 | 9,459,000 | 0.23% | ||
| 44 | CREDIT SUISSE AG/ | 282,337 | 9,071,000 | 0.22% | ||
| 45 | IRONBRIDGE CAPITAL MANAGEMENT LP | 261,564 | 8,404,000 | 0.20% | ||
| 46 | VOYA INVESTMENT MANAGEMENT LLC | 253,642 | 8,150,000 | 0.20% | ||
| 47 | GUGGENHEIM CAPITAL LLC | 247,966 | 7,967,000 | 0.19% | ||
| 48 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 233,400 | 7,749,000 | 0.19% | ||
| 49 | COMMONWEALTH BANK OF AUSTRALIA | 237,994 | 7,647,000 | 0.19% | ||
| 50 | STATE FARM MUTUAL AUTOMOBILE INSURANCE CO | 233,500 | 7,502,000 | 0.18% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
