| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 43,238,967 | 1,747,287,000 | 31.14% | ||
| 2 | BAILLIE GIFFORD & CO | 17,116,142 | 691,663,000 | 12.33% | ||
| 3 | FMR LLC | 14,588,049 | 589,503,000 | 10.51% | ||
| 4 | PRIMECAP MANAGEMENT CO/CA/ | 13,514,712 | 546,130,000 | 9.73% | ||
| 5 | VANGUARD GROUP INC | 7,110,502 | 287,335,000 | 5.12% | ||
| 6 | Artisan Partners Limited Partnership | 4,206,104 | 169,969,000 | 3.03% | ||
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,689,989 | 149,112,000 | 2.66% | ||
| 8 | WASATCH ADVISORS LP | 2,858,565 | 115,515,000 | 2.06% | ||
| 9 | BlackRock Fund Advisors | 2,846,565 | 115,030,000 | 2.05% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 2,554,319 | 103,220,000 | 1.84% | ||
| 11 | STATE STREET CORP | 2,012,517 | 81,321,000 | 1.45% | ||
| 12 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 1,428,393 | 57,721,000 | 1.03% | ||
| 13 | OppenheimerFunds, Inc. | 1,400,000 | 56,574,000 | 1.01% | ||
| 14 | Redmile Group, LLC | 1,381,477 | 55,825,000 | 1.00% | ||
| 15 | PINNACLE ASSOCIATES LTD | 1,186,218 | 47,935,000 | 0.85% | ||
| 16 | DEUTSCHE BANK AG\ | 970,683 | 39,223,000 | 0.70% | ||
| 17 | NORGES BANK | 910,520 | 36,794,000 | 0.66% | ||
| 18 | Mitsubishi UFJ Trust & Banking Corp | 888,429 | 35,901,000 | 0.64% | ||
| 19 | EVENTIDE ASSET MANAGEMENT, LLC | 835,506 | 33,763,000 | 0.60% | ||
| 20 | CITADEL ADVISORS LLC | 754,281 | 30,480,000 | 0.54% | ||
| 21 | FIRST TRUST ADVISORS LP | 749,848 | 30,301,000 | 0.54% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 733,149 | 29,626,000 | 0.53% | ||
| 23 | BLAIR WILLIAM & CO/IL | 696,200 | 28,133,000 | 0.50% | ||
| 24 | Lagoda Investment Management, L.P. | 565,243 | 22,841,000 | 0.41% | ||
| 25 | THORNBURG INVESTMENT MANAGEMENT INC | 432,164 | 17,464,000 | 0.31% | ||
| 26 | Bank of New York Mellon Corp | 419,602 | 16,956,000 | 0.30% | ||
| 27 | NORTHERN TRUST CORP | 415,410 | 16,786,000 | 0.30% | ||
| 28 | NEW YORK STATE COMMON RETIREMENT FUND | 402,540 | 16,267,000 | 0.29% | ||
| 29 | EMERALD ACQUISITION LTD. | 401,398 | 16,220,000 | 0.29% | ||
| 30 | BANK OF AMERICA CORP /DE/ | 392,696 | 15,869,000 | 0.28% | ||
| 31 | BALYASNY ASSET MANAGEMENT L.P. | 390,000 | 15,760,000 | 0.28% | ||
| 32 | BLACKROCK ADVISORS LLC | 371,755 | 15,023,000 | 0.27% | ||
| 33 | GOLDMAN SACHS GROUP INC | 340,325 | 13,753,000 | 0.25% | ||
| 34 | BLUE JAY CAPITAL MANAGEMENT, LLC | 328,430 | 13,272,000 | 0.24% | ||
| 35 | PointState Capital LP | 300,000 | 12,123,000 | 0.22% | ||
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 290,178 | 11,726,000 | 0.21% | ||
| 37 | CREDIT SUISSE AG/ | 285,131 | 11,524,000 | 0.21% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 252,113 | 10,188,000 | 0.18% | ||
| 39 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 236,300 | 9,549,000 | 0.17% | ||
| 40 | BOXER CAPITAL, LLC | 232,600 | 9,399,000 | 0.17% | ||
| 41 | MANNING & NAPIER ADVISORS LLC | 228,321 | 9,224,000 | 0.16% | ||
| 42 | DIMENSIONAL FUND ADVISORS LP | 211,825 | 8,560,000 | 0.15% | ||
| 43 | LORD, ABBETT & CO. LLC | 210,174 | 8,493,000 | 0.15% | ||
| 44 | ROYAL BANK OF CANADA | 207,282 | 8,376,000 | 0.15% | ||
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 203,507 | 8,224,000 | 0.15% | ||
| 46 | Invesco Ltd. | 196,420 | 7,937,000 | 0.14% | ||
| 47 | VAN ECK ASSOCIATES CORP | 181,517 | 7,335,000 | 0.13% | ||
| 48 | STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 179,627 | 7,258,000 | 0.13% | ||
| 49 | Swiss National Bank | 177,900 | 7,189,000 | 0.13% | ||
| 50 | CANADA PENSION PLAN INVESTMENT BOARD | 175,600 | 7,096,000 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
