| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 43,235,267 | 1,517,126,000 | 30.43% | ||
| 2 | BAILLIE GIFFORD & CO | 17,270,681 | 606,029,000 | 12.16% | ||
| 3 | FMR LLC | 16,867,149 | 591,868,000 | 11.87% | ||
| 4 | PRIMECAP MANAGEMENT CO/CA/ | 13,589,187 | 476,845,000 | 9.56% | ||
| 5 | VANGUARD GROUP INC | 6,932,099 | 243,248,000 | 4.88% | ||
| 6 | Artisan Partners Limited Partnership | 4,372,346 | 153,426,000 | 3.08% | ||
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,695,953 | 129,691,000 | 2.60% | ||
| 8 | BlackRock Fund Advisors | 2,896,247 | 101,629,000 | 2.04% | ||
| 9 | WASATCH ADVISORS LP | 2,864,018 | 96,346,000 | 1.93% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 2,618,683 | 91,890,000 | 1.84% | ||
| 11 | STATE STREET CORP | 2,319,710 | 81,406,000 | 1.63% | ||
| 12 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 1,763,796 | 61,892,000 | 1.24% | ||
| 13 | OppenheimerFunds, Inc. | 1,400,000 | 49,126,000 | 0.99% | ||
| 14 | Invesco Ltd. | 1,269,441 | 44,545,000 | 0.89% | ||
| 15 | FIRST TRUST ADVISORS LP | 1,256,085 | 44,076,000 | 0.88% | ||
| 16 | PINNACLE ASSOCIATES LTD | 1,197,610 | 42,024,000 | 0.84% | ||
| 17 | Redmile Group, LLC | 970,121 | 34,042,000 | 0.68% | ||
| 18 | Mitsubishi UFJ Trust & Banking Corp | 903,839 | 31,716,000 | 0.64% | ||
| 19 | NORGES BANK | 838,784 | 29,433,000 | 0.59% | ||
| 20 | EVENTIDE ASSET MANAGEMENT, LLC | 835,506 | 29,318,000 | 0.59% | ||
| 21 | THORNBURG INVESTMENT MANAGEMENT INC | 792,602 | 27,812,000 | 0.56% | ||
| 22 | DEUTSCHE BANK AG\ | 782,468 | 27,456,000 | 0.55% | ||
| 23 | BLAIR WILLIAM & CO/IL | 712,572 | 25,004,000 | 0.50% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 711,458 | 24,965,000 | 0.50% | ||
| 25 | Lagoda Investment Management, L.P. | 584,539 | 20,511,000 | 0.41% | ||
| 26 | RUSSELL FRANK CO/ | 460,520 | 16,160,000 | 0.32% | ||
| 27 | Bank of New York Mellon Corp | 442,190 | 15,517,000 | 0.31% | ||
| 28 | NORTHERN TRUST CORP | 425,815 | 14,942,000 | 0.30% | ||
| 29 | NEW YORK STATE COMMON RETIREMENT FUND | 396,540 | 13,915,000 | 0.28% | ||
| 30 | BLACKROCK ADVISORS LLC | 370,334 | 12,995,000 | 0.26% | ||
| 31 | BANK OF AMERICA CORP /DE/ | 368,652 | 12,936,000 | 0.26% | ||
| 32 | CREDIT SUISSE AG/ | 328,987 | 11,543,000 | 0.23% | ||
| 33 | TIAA CREF INVESTMENT MANAGEMENT LLC | 309,512 | 10,861,000 | 0.22% | ||
| 34 | GOLDMAN SACHS GROUP INC | 307,016 | 10,773,000 | 0.22% | ||
| 35 | MANNING & NAPIER ADVISORS LLC | 289,140 | 10,144,000 | 0.20% | ||
| 36 | CANADA PENSION PLAN INVESTMENT BOARD | 288,800 | 10,134,000 | 0.20% | ||
| 37 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 243,700 | 8,551,000 | 0.17% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 237,533 | 8,336,000 | 0.17% | ||
| 39 | BOXER CAPITAL, LLC | 233,600 | 8,197,000 | 0.16% | ||
| 40 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 224,099 | 7,864,000 | 0.16% | ||
| 41 | MILLENNIUM MANAGEMENT LLC | 224,089 | 7,863,000 | 0.16% | ||
| 42 | MORGAN STANLEY | 223,633 | 7,848,000 | 0.16% | ||
| 43 | VAN ECK ASSOCIATES CORP | 221,065 | 7,757,000 | 0.16% | ||
| 44 | ROYAL BANK OF CANADA | 213,546 | 7,493,000 | 0.15% | ||
| 45 | MACQUARIE GROUP LTD | 211,036 | 7,405,000 | 0.15% | ||
| 46 | DIMENSIONAL FUND ADVISORS LP | 208,840 | 7,326,000 | 0.15% | ||
| 47 | PDT Partners, LLC | 190,500 | 6,685,000 | 0.13% | ||
| 48 | Swiss National Bank | 186,700 | 6,327,000 | 0.13% | ||
| 49 | IRONBRIDGE CAPITAL MANAGEMENT LP | 175,611 | 6,162,000 | 0.12% | ||
| 50 | STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 152,692 | 5,358,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
