| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 22,475,729 | 835,648,000 | 17.67% | ||
| 2 | FMR LLC | 18,517,005 | 688,462,000 | 14.56% | ||
| 3 | BAILLIE GIFFORD & CO | 14,703,706 | 546,684,000 | 11.56% | ||
| 4 | PRIMECAP MANAGEMENT CO/CA/ | 10,954,900 | 407,303,000 | 8.61% | ||
| 5 | VANGUARD GROUP INC | 6,083,674 | 226,190,000 | 4.78% | ||
| 6 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 5,155,000 | 191,663,000 | 4.05% | ||
| 7 | CAPITAL GUARDIAN TRUST CO | 4,949,060 | 184,006,000 | 3.89% | ||
| 8 | WASATCH ADVISORS LP | 3,259,240 | 121,179,000 | 2.56% | ||
| 9 | WELLINGTON MANAGEMENT GROUP LLP | 2,655,747 | 98,741,000 | 2.09% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 2,475,160 | 92,026,000 | 1.95% | ||
| 11 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,337,624 | 86,913,000 | 1.84% | ||
| 12 | BlackRock Fund Advisors | 2,300,777 | 85,543,000 | 1.81% | ||
| 13 | Capital International Investors | 2,294,200 | 85,298,000 | 1.80% | ||
| 14 | STATE STREET CORP | 1,583,890 | 58,884,000 | 1.25% | ||
| 15 | OppenheimerFunds, Inc. | 1,400,000 | 52,052,000 | 1.10% | ||
| 16 | EAGLE ASSET MANAGEMENT INC | 1,328,300 | 49,386,000 | 1.04% | ||
| 17 | PINNACLE ASSOCIATES LTD | 1,304,461 | 48,500,000 | 1.03% | ||
| 18 | Invesco Ltd. | 1,225,395 | 45,560,000 | 0.96% | ||
| 19 | MORGAN STANLEY | 1,050,243 | 39,048,000 | 0.83% | ||
| 20 | Mitsubishi UFJ Trust & Banking Corp | 827,300 | 30,759,000 | 0.65% | ||
| 21 | NORGES BANK | 806,985 | 30,003,000 | 0.63% | ||
| 22 | ROCKEFELLER FINANCIAL SERVICES INC | 794,453 | 29,538,000 | 0.62% | ||
| 23 | BLACKROCK ADVISORS LLC | 756,401 | 28,123,000 | 0.59% | ||
| 24 | FEDERATED HERMES, INC. | 752,150 | 27,965,000 | 0.59% | ||
| 25 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 746,997 | 27,773,000 | 0.59% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 701,400 | 26,078,000 | 0.55% | Put | |
| 27 | DEUTSCHE BANK AG\ | 687,764 | 25,568,000 | 0.54% | ||
| 28 | BLAIR WILLIAM & CO/IL | 616,829 | 22,933,000 | 0.49% | ||
| 29 | SECTORAL ASSET MANAGEMENT INC | 609,819 | 22,673,000 | 0.48% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 568,987 | 21,154,000 | 0.45% | ||
| 31 | GOLDMAN SACHS GROUP INC | 525,523 | 19,539,000 | 0.41% | ||
| 32 | Capital International Sarl | 521,100 | 19,374,000 | 0.41% | ||
| 33 | MANNING & NAPIER ADVISORS LLC | 485,810 | 18,061,000 | 0.38% | ||
| 34 | NORTHERN TRUST CORP | 477,623 | 17,758,000 | 0.38% | ||
| 35 | CAPITAL INTERNATIONAL LTD /CA/ | 468,800 | 17,430,000 | 0.37% | ||
| 36 | BANK OF AMERICA CORP /DE/ | 466,612 | 17,348,000 | 0.37% | ||
| 37 | BROWN ADVISORY INC | 442,283 | 16,444,000 | 0.35% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 427,700 | 15,902,000 | 0.34% | Call | |
| 39 | Bank of New York Mellon Corp | 380,504 | 14,146,000 | 0.30% | ||
| 40 | Capital World Investors | 372,000 | 13,831,000 | 0.29% | ||
| 41 | BlackRock Group LTD | 356,077 | 13,238,000 | 0.28% | ||
| 42 | TIAA CREF INVESTMENT MANAGEMENT LLC | 310,732 | 11,553,000 | 0.24% | ||
| 43 | MACQUARIE GROUP LTD | 303,093 | 11,269,000 | 0.24% | ||
| 44 | AXA S.A. | 282,190 | 10,492,000 | 0.22% | ||
| 45 | Capital International, Inc./CA/ | 280,700 | 10,436,000 | 0.22% | ||
| 46 | COMMONWEALTH BANK OF AUSTRALIA | 263,809 | 9,808,000 | 0.21% | ||
| 47 | Jefferies Group LLC | 239,500 | 8,905,000 | 0.19% | Call | |
| 48 | IRONBRIDGE CAPITAL MANAGEMENT LP | 234,867 | 8,732,000 | 0.18% | ||
| 49 | STATE FARM MUTUAL AUTOMOBILE INSURANCE CO | 233,500 | 8,682,000 | 0.18% | ||
| 50 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 233,400 | 8,678,000 | 0.18% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
