| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 36,029,746 | 1,389,307,000 | 24.94% | ||
| 2 | FMR LLC | 17,163,025 | 661,806,000 | 11.88% | ||
| 3 | BAILLIE GIFFORD & CO | 17,111,091 | 659,051,000 | 11.83% | ||
| 4 | PRIMECAP MANAGEMENT CO/CA/ | 12,865,950 | 496,111,000 | 8.90% | ||
| 5 | VANGUARD GROUP INC | 6,873,711 | 265,051,000 | 4.76% | ||
| 6 | FIRST TRUST ADVISORS LP | 3,646,425 | 140,606,000 | 2.52% | ||
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,505,876 | 135,187,000 | 2.43% | ||
| 8 | Artisan Partners Limited Partnership | 3,467,125 | 133,692,000 | 2.40% | ||
| 9 | CITADEL ADVISORS LLC | 3,422,301 | 131,964,000 | 2.37% | ||
| 10 | WASATCH ADVISORS LP | 2,960,284 | 114,149,000 | 2.05% | ||
| 11 | BlackRock Fund Advisors | 2,830,806 | 109,156,000 | 1.96% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 2,556,644 | 98,584,000 | 1.77% | ||
| 13 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 1,842,396 | 71,043,000 | 1.28% | ||
| 14 | ALPS ADVISORS INC | 180,437 | 69,577,000 | 1.25% | ||
| 15 | STATE STREET CORP | 1,681,774 | 64,850,000 | 1.16% | ||
| 16 | OppenheimerFunds, Inc. | 1,400,000 | 53,984,000 | 0.97% | ||
| 17 | Redmile Group, LLC | 1,390,173 | 53,605,000 | 0.96% | ||
| 18 | Invesco Ltd. | 1,336,959 | 51,553,000 | 0.93% | ||
| 19 | SECTORAL ASSET MANAGEMENT INC | 1,269,075 | 48,936,000 | 0.88% | ||
| 20 | PINNACLE ASSOCIATES LTD | 1,251,129 | 48,244,000 | 0.87% | ||
| 21 | THORNBURG INVESTMENT MANAGEMENT INC | 1,077,121 | 41,534,000 | 0.75% | ||
| 22 | DEUTSCHE BANK AG\ | 1,026,324 | 39,571,000 | 0.71% | ||
| 23 | WELLINGTON MANAGEMENT GROUP LLP | 934,572 | 36,039,000 | 0.65% | ||
| 24 | MORGAN STANLEY | 932,962 | 35,976,000 | 0.65% | ||
| 25 | NORGES BANK | 883,124 | 34,053,000 | 0.61% | ||
| 26 | Mitsubishi UFJ Trust & Banking Corp | 830,190 | 32,012,000 | 0.57% | ||
| 27 | Lagoda Investment Management, L.P. | 636,730 | 24,552,000 | 0.44% | ||
| 28 | BLAIR WILLIAM & CO/IL | 625,120 | 24,104,000 | 0.43% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 618,437 | 23,846,000 | 0.43% | ||
| 30 | Bank of New York Mellon Corp | 456,949 | 17,620,000 | 0.32% | ||
| 31 | NORTHERN TRUST CORP | 391,241 | 15,087,000 | 0.27% | ||
| 32 | BANK OF AMERICA CORP /DE/ | 366,912 | 14,148,000 | 0.25% | ||
| 33 | AXA S.A. | 356,420 | 13,744,000 | 0.25% | ||
| 34 | NEW YORK STATE COMMON RETIREMENT FUND | 344,653 | 13,290,000 | 0.24% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 299,600 | 11,553,000 | 0.21% | Put | |
| 36 | EAGLE ASSET MANAGEMENT INC | 297,245 | 11,461,000 | 0.21% | ||
| 37 | CHILTON INVESTMENT CO INC. | 293,416 | 11,315,000 | 0.20% | ||
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 292,054 | 11,262,000 | 0.20% | ||
| 39 | CREDIT SUISSE AG/ | 272,914 | 10,523,000 | 0.19% | ||
| 40 | GUGGENHEIM CAPITAL LLC | 272,156 | 10,494,000 | 0.19% | ||
| 41 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 258,400 | 9,964,000 | 0.18% | ||
| 42 | MANNING & NAPIER ADVISORS LLC | 252,470 | 9,734,000 | 0.17% | ||
| 43 | LORD, ABBETT & CO. LLC | 251,123 | 9,683,000 | 0.17% | ||
| 44 | BLACKROCK ADVISORS LLC | 240,099 | 9,258,000 | 0.17% | ||
| 45 | ROYAL BANK OF CANADA | 229,461 | 8,848,000 | 0.16% | ||
| 46 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 216,347 | 8,343,000 | 0.15% | ||
| 47 | MILLENNIUM MANAGEMENT LLC | 212,484 | 8,193,000 | 0.15% | ||
| 48 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 211,621 | 8,160,000 | 0.15% | ||
| 49 | MACQUARIE GROUP LTD | 196,351 | 7,571,000 | 0.14% | ||
| 50 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 192,324 | 7,416,000 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
