| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 37,293,728 | 1,673,743,000 | 26.24% | ||
| 2 | BAILLIE GIFFORD & CO | 17,152,807 | 769,818,000 | 12.07% | ||
| 3 | FMR LLC | 17,130,496 | 768,817,000 | 12.05% | ||
| 4 | PRIMECAP MANAGEMENT CO/CA/ | 12,882,175 | 578,152,000 | 9.06% | ||
| 5 | VANGUARD GROUP INC | 6,881,088 | 308,823,000 | 4.84% | ||
| 6 | Artisan Partners Limited Partnership | 4,382,053 | 196,667,000 | 3.08% | ||
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,505,470 | 157,325,000 | 2.47% | ||
| 8 | FIRST TRUST ADVISORS LP | 3,380,705 | 151,726,000 | 2.38% | ||
| 9 | WASATCH ADVISORS LP | 2,914,497 | 130,803,000 | 2.05% | ||
| 10 | BlackRock Fund Advisors | 2,705,468 | 121,421,000 | 1.90% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 2,622,216 | 117,685,000 | 1.84% | ||
| 12 | STATE STREET CORP | 1,961,413 | 88,018,000 | 1.38% | ||
| 13 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 1,621,001 | 72,751,000 | 1.14% | ||
| 14 | OppenheimerFunds, Inc. | 1,400,000 | 62,832,000 | 0.98% | ||
| 15 | Redmile Group, LLC | 1,372,492 | 61,597,000 | 0.97% | ||
| 16 | Invesco Ltd. | 1,297,542 | 58,234,000 | 0.91% | ||
| 17 | SECTORAL ASSET MANAGEMENT INC | 1,275,775 | 57,257,000 | 0.90% | ||
| 18 | PINNACLE ASSOCIATES LTD | 1,183,190 | 53,102,000 | 0.83% | ||
| 19 | THORNBURG INVESTMENT MANAGEMENT INC | 1,076,252 | 48,302,000 | 0.76% | ||
| 20 | NORGES BANK | 883,124 | 39,635,000 | 0.62% | ||
| 21 | CITADEL ADVISORS LLC | 849,730 | 38,136,000 | 0.60% | ||
| 22 | Mitsubishi UFJ Trust & Banking Corp | 818,050 | 36,714,000 | 0.58% | ||
| 23 | WELLINGTON MANAGEMENT GROUP LLP | 781,199 | 35,061,000 | 0.55% | ||
| 24 | MORGAN STANLEY | 744,747 | 33,425,000 | 0.52% | ||
| 25 | DEUTSCHE BANK AG\ | 682,906 | 30,645,000 | 0.48% | ||
| 26 | BLAIR WILLIAM & CO/IL | 681,900 | 30,603,000 | 0.48% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 659,393 | 29,593,000 | 0.46% | ||
| 28 | Lagoda Investment Management, L.P. | 631,307 | 28,333,000 | 0.44% | ||
| 29 | EVENTIDE ASSET MANAGEMENT, LLC | 545,300 | 24,473,000 | 0.38% | ||
| 30 | Bank of New York Mellon Corp | 458,633 | 20,582,000 | 0.32% | ||
| 31 | RUSSELL FRANK CO/ | 412,586 | 18,641,000 | 0.29% | ||
| 32 | BANK OF AMERICA CORP /DE/ | 409,008 | 18,357,000 | 0.29% | ||
| 33 | NORTHERN TRUST CORP | 401,250 | 18,008,000 | 0.28% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 390,100 | 17,508,000 | 0.27% | Call | |
| 35 | NEW YORK STATE COMMON RETIREMENT FUND | 388,566 | 17,439,000 | 0.27% | ||
| 36 | MANNING & NAPIER ADVISORS LLC | 357,750 | 16,054,000 | 0.25% | ||
| 37 | AXA S.A. | 349,082 | 15,667,000 | 0.25% | ||
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 306,654 | 13,763,000 | 0.22% | ||
| 39 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 294,700 | 13,226,000 | 0.21% | ||
| 40 | BLACKROCK ADVISORS LLC | 278,255 | 12,488,000 | 0.20% | ||
| 41 | CREDIT SUISSE AG/ | 257,017 | 11,534,000 | 0.18% | ||
| 42 | D. E. Shaw & Co., Inc. | 242,005 | 10,861,000 | 0.17% | ||
| 43 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 233,064 | 10,460,000 | 0.16% | ||
| 44 | Ghost Tree Capital, LLC | 225,000 | 10,098,000 | 0.16% | ||
| 45 | VAN ECK ASSOCIATES CORP | 222,246 | 9,974,000 | 0.16% | ||
| 46 | UBS Group AG | 210,435 | 9,444,000 | 0.15% | ||
| 47 | GUGGENHEIM CAPITAL LLC | 205,705 | 9,232,000 | 0.14% | ||
| 48 | ROYAL BANK OF CANADA | 205,335 | 9,215,000 | 0.14% | ||
| 49 | MACQUARIE GROUP LTD | 204,530 | 9,179,000 | 0.14% | ||
| 50 | CANADA PENSION PLAN INVESTMENT BOARD | 203,900 | 9,151,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
