| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 20,739,426 | 944,887,000 | 16.03% | ||
| 2 | FMR LLC | 18,438,783 | 840,072,000 | 14.26% | ||
| 3 | BAILLIE GIFFORD & CO | 12,861,181 | 585,956,000 | 9.94% | ||
| 4 | PRIMECAP MANAGEMENT CO/CA/ | 11,007,005 | 501,479,000 | 8.51% | ||
| 5 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 6,626,000 | 301,881,000 | 5.12% | ||
| 6 | VANGUARD GROUP INC | 6,320,727 | 287,972,000 | 4.89% | ||
| 7 | CAPITAL GUARDIAN TRUST CO | 6,151,231 | 280,250,000 | 4.76% | ||
| 8 | WELLINGTON MANAGEMENT GROUP LLP | 2,953,577 | 134,565,000 | 2.28% | ||
| 9 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,841,203 | 129,445,000 | 2.20% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 2,719,890 | 123,918,000 | 2.10% | ||
| 11 | BlackRock Fund Advisors | 2,296,584 | 104,632,000 | 1.78% | ||
| 12 | WASATCH ADVISORS LP | 2,146,505 | 97,795,000 | 1.66% | ||
| 13 | Capital International Investors | 1,769,000 | 80,596,000 | 1.37% | ||
| 14 | EAGLE ASSET MANAGEMENT INC | 1,742,147 | 79,372,000 | 1.35% | ||
| 15 | STATE STREET CORP | 1,542,679 | 70,290,000 | 1.19% | ||
| 16 | BLACKROCK ADVISORS LLC | 1,426,337 | 64,984,000 | 1.10% | ||
| 17 | PINNACLE ASSOCIATES LTD | 1,424,186 | 64,886,000 | 1.10% | ||
| 18 | OppenheimerFunds, Inc. | 1,400,000 | 63,784,000 | 1.08% | ||
| 19 | USS Investment Management Ltd | 1,203,291 | 54,822,000 | 0.93% | ||
| 20 | Invesco Ltd. | 1,055,416 | 48,085,000 | 0.82% | ||
| 21 | ROCKEFELLER FINANCIAL SERVICES INC | 988,657 | 45,044,000 | 0.76% | ||
| 22 | MORGAN STANLEY | 925,345 | 42,158,000 | 0.72% | ||
| 23 | Mitsubishi UFJ Trust & Banking Corp | 854,740 | 38,942,000 | 0.66% | ||
| 24 | DEUTSCHE BANK AG\ | 823,472 | 37,515,000 | 0.64% | ||
| 25 | FEDERATED HERMES, INC. | 794,023 | 36,176,000 | 0.61% | ||
| 26 | NORGES BANK | 781,238 | 35,593,000 | 0.60% | ||
| 27 | BlackRock Group LTD | 649,363 | 29,585,000 | 0.50% | ||
| 28 | RAINIER INVESTMENT MANAGEMENT LLC | 628,760 | 28,644,000 | 0.49% | ||
| 29 | BLAIR WILLIAM & CO/IL | 583,852 | 26,600,000 | 0.45% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 560,357 | 25,529,000 | 0.43% | ||
| 31 | Capital International Sarl | 514,200 | 23,427,000 | 0.40% | ||
| 32 | HealthCor Management, L.P. | 500,000 | 22,780,000 | 0.39% | Put | |
| 33 | NORTHERN TRUST CORP | 497,850 | 22,682,000 | 0.38% | ||
| 34 | BROWN ADVISORY INC | 462,629 | 21,078,000 | 0.36% | ||
| 35 | CAPITAL INTERNATIONAL LTD /CA/ | 462,100 | 21,053,000 | 0.36% | ||
| 36 | SECTORAL ASSET MANAGEMENT INC | 442,819 | 20,175,000 | 0.34% | ||
| 37 | BANK OF AMERICA CORP /DE/ | 416,007 | 18,954,000 | 0.32% | ||
| 38 | FIRST TRUST ADVISORS LP | 415,810 | 18,944,000 | 0.32% | ||
| 39 | Bank of New York Mellon Corp | 408,899 | 18,629,000 | 0.32% | ||
| 40 | BARCLAYS PLC | 395,100 | 17,780,000 | 0.30% | Put | |
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 377,000 | 17,176,000 | 0.29% | Call | |
| 42 | Capital World Investors | 372,000 | 16,948,000 | 0.29% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 364,000 | 16,584,000 | 0.28% | Put | |
| 44 | Capital International, Inc./CA/ | 333,400 | 15,190,000 | 0.26% | ||
| 45 | TIAA CREF INVESTMENT MANAGEMENT LLC | 333,023 | 15,173,000 | 0.26% | ||
| 46 | BlackRock Finance, Inc. | 304,397 | 13,868,000 | 0.24% | ||
| 47 | AXA S.A. | 290,181 | 13,221,000 | 0.22% | ||
| 48 | GOLDMAN SACHS GROUP INC | 283,218 | 12,904,000 | 0.22% | ||
| 49 | ALLIANCEBERNSTEIN L.P. | 281,236 | 12,813,000 | 0.22% | ||
| 50 | MACQUARIE GROUP LTD | 277,575 | 12,646,000 | 0.21% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
