| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 45,711,856 | 2,412,215,000 | 32.97% | ||
| 2 | BAILLIE GIFFORD & CO | 16,570,644 | 874,433,000 | 11.95% | ||
| 3 | PRIMECAP MANAGEMENT CO/CA/ | 13,230,162 | 698,156,000 | 9.54% | ||
| 4 | FMR LLC | 11,777,732 | 621,511,000 | 8.49% | ||
| 5 | VANGUARD GROUP INC | 7,087,643 | 374,014,000 | 5.11% | ||
| 6 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,564,006 | 188,073,000 | 2.57% | ||
| 7 | BlackRock Fund Advisors | 3,110,333 | 164,132,000 | 2.24% | ||
| 8 | WASATCH ADVISORS LP | 2,728,810 | 143,999,000 | 1.97% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 2,649,393 | 139,808,000 | 1.91% | ||
| 10 | STATE STREET CORP | 2,566,041 | 135,404,000 | 1.85% | ||
| 11 | Artisan Partners Limited Partnership | 2,182,971 | 115,195,000 | 1.57% | ||
| 12 | Redmile Group, LLC | 1,520,904 | 80,258,000 | 1.10% | ||
| 13 | OppenheimerFunds, Inc. | 1,400,000 | 73,878,000 | 1.01% | ||
| 14 | PINNACLE ASSOCIATES LTD | 1,107,507 | 58,443,000 | 0.80% | ||
| 15 | NORGES BANK | 1,089,077 | 57,470,000 | 0.79% | ||
| 16 | Mitsubishi UFJ Trust & Banking Corp | 1,047,516 | 55,277,000 | 0.76% | ||
| 17 | GOLDMAN SACHS GROUP INC | 969,555 | 51,163,000 | 0.70% | ||
| 18 | FIRST TRUST ADVISORS LP | 953,352 | 50,308,000 | 0.69% | ||
| 19 | DEUTSCHE BANK AG\ | 853,710 | 45,044,000 | 0.62% | ||
| 20 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 760,744 | 40,144,000 | 0.55% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 734,643 | 38,754,000 | 0.53% | ||
| 22 | BLAIR WILLIAM & CO/IL | 636,302 | 33,578,000 | 0.46% | ||
| 23 | EVENTIDE ASSET MANAGEMENT, LLC | 560,000 | 29,551,000 | 0.40% | ||
| 24 | NORTHERN TRUST CORP | 541,366 | 28,567,000 | 0.39% | ||
| 25 | BLACKROCK ADVISORS LLC | 526,785 | 27,799,000 | 0.38% | ||
| 26 | Lagoda Investment Management, L.P. | 517,829 | 27,326,000 | 0.37% | ||
| 27 | Matrix Capital Management Company, LP | 498,000 | 26,279,000 | 0.36% | ||
| 28 | TWO SIGMA INVESTMENTS, LP | 469,039 | 24,751,000 | 0.34% | ||
| 29 | BlackRock Group LTD | 461,929 | 24,375,000 | 0.33% | ||
| 30 | BANK OF AMERICA CORP /DE/ | 452,927 | 23,901,000 | 0.33% | ||
| 31 | TIAA CREF INVESTMENT MANAGEMENT LLC | 434,967 | 22,953,000 | 0.31% | ||
| 32 | Bank of New York Mellon Corp | 414,024 | 21,847,000 | 0.30% | ||
| 33 | TWO SIGMA ADVISERS, LP | 389,222 | 20,539,000 | 0.28% | ||
| 34 | THORNBURG INVESTMENT MANAGEMENT INC | 318,740 | 16,820,000 | 0.23% | ||
| 35 | NEW YORK STATE COMMON RETIREMENT FUND | 312,251 | 16,477,000 | 0.23% | ||
| 36 | Avoro Capital Advisors LLC | 295,533 | 15,595,000 | 0.21% | ||
| 37 | TEACHERS ADVISORS, LLC | 287,808 | 15,188,000 | 0.21% | ||
| 38 | Swiss National Bank | 275,600 | 14,543,000 | 0.20% | ||
| 39 | Sumitomo Mitsui Trust Group, Inc. | 275,157 | 14,520,000 | 0.20% | ||
| 40 | CREDIT SUISSE AG/ | 262,106 | 13,832,000 | 0.19% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 261,897 | 13,821,000 | 0.19% | ||
| 42 | RENAISSANCE TECHNOLOGIES LLC | 253,313 | 13,367,000 | 0.18% | ||
| 43 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 228,900 | 12,079,000 | 0.17% | ||
| 44 | RUSSELL INVESTMENTS GROUP, LTD. | 215,246 | 11,492,000 | 0.16% | ||
| 45 | DIMENSIONAL FUND ADVISORS LP | 205,842 | 10,863,000 | 0.15% | ||
| 46 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 199,807 | 10,544,000 | 0.14% | ||
| 47 | ROYAL BANK OF CANADA | 191,500 | 10,106,000 | 0.14% | ||
| 48 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 188,705 | 9,959,000 | 0.14% | ||
| 49 | EAGLE ASSET MANAGEMENT INC | 173,589 | 9,160,000 | 0.13% | ||
| 50 | STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 169,406 | 8,940,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
