| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 30,870,262 | 1,494,121,000 | 24.04% | ||
| 2 | FMR LLC | 18,724,654 | 906,274,000 | 14.58% | ||
| 3 | BAILLIE GIFFORD & CO | 15,161,292 | 733,806,000 | 11.81% | ||
| 4 | PRIMECAP MANAGEMENT CO/CA/ | 11,899,100 | 575,916,000 | 9.27% | ||
| 5 | VANGUARD GROUP INC | 6,230,220 | 301,543,000 | 4.85% | ||
| 6 | FIRST TRUST ADVISORS LP | 3,216,228 | 155,665,000 | 2.50% | ||
| 7 | WASATCH ADVISORS LP | 3,034,022 | 146,847,000 | 2.36% | ||
| 8 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,720,256 | 131,660,000 | 2.12% | ||
| 9 | BlackRock Fund Advisors | 2,562,671 | 124,033,000 | 2.00% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 2,471,594 | 119,625,000 | 1.92% | ||
| 11 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 2,355,005 | 113,982,000 | 1.83% | ||
| 12 | Artisan Partners Limited Partnership | 2,002,164 | 96,905,000 | 1.56% | ||
| 13 | STATE STREET CORP | 1,616,012 | 78,214,000 | 1.26% | ||
| 14 | OppenheimerFunds, Inc. | 1,400,000 | 67,760,000 | 1.09% | ||
| 15 | PINNACLE ASSOCIATES LTD | 1,334,136 | 64,572,000 | 1.04% | ||
| 16 | Invesco Ltd. | 1,329,486 | 64,347,000 | 1.04% | ||
| 17 | SECTORAL ASSET MANAGEMENT INC | 1,262,075 | 61,084,000 | 0.98% | ||
| 18 | MORGAN STANLEY | 987,386 | 47,790,000 | 0.77% | ||
| 19 | NORGES BANK | 931,041 | 45,062,000 | 0.73% | ||
| 20 | WELLINGTON MANAGEMENT GROUP LLP | 865,627 | 41,897,000 | 0.67% | ||
| 21 | DEUTSCHE BANK AG\ | 849,192 | 41,098,000 | 0.66% | ||
| 22 | Mitsubishi UFJ Trust & Banking Corp | 753,050 | 36,448,000 | 0.59% | ||
| 23 | Lagoda Investment Management, L.P. | 626,236 | 30,310,000 | 0.49% | ||
| 24 | BLAIR WILLIAM & CO/IL | 597,728 | 28,930,000 | 0.47% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 591,812 | 28,643,000 | 0.46% | ||
| 26 | Redmile Group, LLC | 529,199 | 25,613,000 | 0.41% | ||
| 27 | THORNBURG INVESTMENT MANAGEMENT INC | 519,983 | 25,167,000 | 0.40% | ||
| 28 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 478,643 | 23,166,000 | 0.37% | ||
| 29 | BANK OF AMERICA CORP /DE/ | 411,774 | 19,930,000 | 0.32% | ||
| 30 | AXA S.A. | 409,525 | 19,821,000 | 0.32% | ||
| 31 | NORTHERN TRUST CORP | 408,277 | 19,761,000 | 0.32% | ||
| 32 | Bank of New York Mellon Corp | 407,578 | 19,727,000 | 0.32% | ||
| 33 | EAGLE ASSET MANAGEMENT INC | 388,173 | 18,787,000 | 0.30% | ||
| 34 | CREDIT SUISSE AG/ | 323,293 | 15,647,000 | 0.25% | ||
| 35 | LORD, ABBETT & CO. LLC | 306,102 | 14,815,000 | 0.24% | ||
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 292,719 | 14,168,000 | 0.23% | ||
| 37 | GUGGENHEIM CAPITAL LLC | 292,125 | 14,139,000 | 0.23% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 279,300 | 13,518,000 | 0.22% | Put | |
| 39 | VOYA INVESTMENT MANAGEMENT LLC | 268,104 | 12,976,000 | 0.21% | ||
| 40 | MANNING & NAPIER ADVISORS LLC | 252,470 | 12,218,000 | 0.20% | ||
| 41 | ROYAL BANK OF CANADA | 251,679 | 12,181,000 | 0.20% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 250,003 | 12,101,000 | 0.19% | ||
| 43 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 233,400 | 11,297,000 | 0.18% | ||
| 44 | BLACKROCK ADVISORS LLC | 231,156 | 11,188,000 | 0.18% | ||
| 45 | VAN ECK ASSOCIATES CORP | 215,755 | 10,443,000 | 0.17% | ||
| 46 | MACQUARIE GROUP LTD | 200,400 | 9,699,000 | 0.16% | ||
| 47 | BVF INC/IL | 200,000 | 9,680,000 | 0.16% | ||
| 48 | GOLDMAN SACHS GROUP INC | 198,635 | 9,614,000 | 0.15% | ||
| 49 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 194,813 | 9,429,000 | 0.15% | ||
| 50 | Allianz Asset Management GmbH | 192,400 | 9,312,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
