| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 28,876,712 | 1,020,792,000 | 22.66% | ||
| 2 | FMR LLC | 18,647,727 | 659,197,000 | 14.63% | ||
| 3 | BAILLIE GIFFORD & CO | 15,253,520 | 539,213,000 | 11.97% | ||
| 4 | PRIMECAP MANAGEMENT CO/CA/ | 11,836,575 | 418,423,000 | 9.29% | ||
| 5 | VANGUARD GROUP INC | 6,135,243 | 216,881,000 | 4.81% | ||
| 6 | WASATCH ADVISORS LP | 3,462,749 | 122,408,000 | 2.72% | ||
| 7 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 3,408,200 | 120,480,000 | 2.67% | ||
| 8 | FIRST TRUST ADVISORS LP | 3,064,329 | 108,324,000 | 2.40% | ||
| 9 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,689,572 | 95,076,000 | 2.11% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 2,546,378 | 90,014,000 | 2.00% | ||
| 11 | BlackRock Fund Advisors | 2,500,648 | 88,398,000 | 1.96% | ||
| 12 | STATE STREET CORP | 1,727,394 | 61,063,000 | 1.36% | ||
| 13 | OppenheimerFunds, Inc. | 1,400,000 | 49,490,000 | 1.10% | ||
| 14 | Invesco Ltd. | 1,384,942 | 48,958,000 | 1.09% | ||
| 15 | PINNACLE ASSOCIATES LTD | 1,372,371 | 48,513,000 | 1.08% | ||
| 16 | SECTORAL ASSET MANAGEMENT INC | 1,260,275 | 44,551,000 | 0.99% | ||
| 17 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,146,593 | 40,532,000 | 0.90% | ||
| 18 | MORGAN STANLEY | 1,096,681 | 38,768,000 | 0.86% | ||
| 19 | Redmile Group, LLC | 1,052,666 | 37,212,000 | 0.83% | ||
| 20 | NORGES BANK | 931,041 | 32,912,000 | 0.73% | ||
| 21 | EAGLE ASSET MANAGEMENT INC | 836,723 | 29,578,000 | 0.66% | ||
| 22 | Mitsubishi UFJ Trust & Banking Corp | 787,430 | 27,836,000 | 0.62% | ||
| 23 | MILLENNIUM MANAGEMENT LLC | 785,805 | 27,778,000 | 0.62% | ||
| 24 | WELLINGTON MANAGEMENT GROUP LLP | 651,898 | 23,045,000 | 0.51% | ||
| 25 | BLAIR WILLIAM & CO/IL | 619,086 | 21,884,000 | 0.49% | ||
| 26 | Lagoda Investment Management, L.P. | 617,204 | 21,818,000 | 0.48% | ||
| 27 | DEUTSCHE BANK AG\ | 580,221 | 20,508,000 | 0.46% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 566,979 | 20,042,000 | 0.44% | ||
| 29 | THORNBURG INVESTMENT MANAGEMENT INC | 519,376 | 18,360,000 | 0.41% | ||
| 30 | MANNING & NAPIER ADVISORS LLC | 492,690 | 17,415,000 | 0.39% | ||
| 31 | AXA S.A. | 470,714 | 16,640,000 | 0.37% | ||
| 32 | NORTHERN TRUST CORP | 414,658 | 14,659,000 | 0.33% | ||
| 33 | Bank of New York Mellon Corp | 392,043 | 13,858,000 | 0.31% | ||
| 34 | BANK OF AMERICA CORP /DE/ | 383,474 | 13,555,000 | 0.30% | ||
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 339,717 | 12,009,000 | 0.27% | ||
| 36 | GOLDMAN SACHS GROUP INC | 323,639 | 11,441,000 | 0.25% | ||
| 37 | BARCLAYS PLC | 306,100 | 10,714,000 | 0.24% | Put | |
| 38 | GUGGENHEIM CAPITAL LLC | 291,533 | 10,306,000 | 0.23% | ||
| 39 | CREDIT SUISSE AG/ | 280,307 | 9,908,000 | 0.22% | ||
| 40 | VOYA INVESTMENT MANAGEMENT LLC | 278,290 | 9,838,000 | 0.22% | ||
| 41 | IRONBRIDGE CAPITAL MANAGEMENT LP | 268,155 | 9,479,000 | 0.21% | ||
| 42 | ROYAL BANK OF CANADA | 238,243 | 8,422,000 | 0.19% | ||
| 43 | BLACKROCK ADVISORS LLC | 231,156 | 8,171,000 | 0.18% | ||
| 44 | Jupiter Investment Management Ltd | 221,848 | 7,842,000 | 0.17% | ||
| 45 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 220,044 | 7,779,000 | 0.17% | ||
| 46 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 233,400 | 7,749,000 | 0.17% | ||
| 47 | BARCLAYS PLC | 218,388 | 7,644,000 | 0.17% | ||
| 48 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 216,000 | 7,636,000 | 0.17% | Put | |
| 49 | SPHERA FUNDS MANAGEMENT LTD. | 200,000 | 7,070,000 | 0.16% | ||
| 50 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 185,274 | 6,549,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
