| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 44,100,294 | 2,381,857,000 | 31.58% | ||
| 2 | BAILLIE GIFFORD & CO | 16,795,793 | 907,142,000 | 12.03% | ||
| 3 | PRIMECAP MANAGEMENT CO/CA/ | 13,420,237 | 724,827,000 | 9.61% | ||
| 4 | FMR LLC | 13,131,642 | 709,240,000 | 9.40% | ||
| 5 | VANGUARD GROUP INC | 7,102,952 | 383,630,000 | 5.09% | ||
| 6 | PRICE T ROWE ASSOCIATES INC /MD/ | 4,752,993 | 256,709,000 | 3.40% | ||
| 7 | Artisan Partners Limited Partnership | 4,104,329 | 221,675,000 | 2.94% | ||
| 8 | BlackRock Fund Advisors | 2,926,613 | 158,066,000 | 2.10% | ||
| 9 | WASATCH ADVISORS LP | 2,844,908 | 153,653,000 | 2.04% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 2,405,109 | 129,900,000 | 1.72% | ||
| 11 | STATE STREET CORP | 1,983,063 | 107,109,000 | 1.42% | ||
| 12 | Redmile Group, LLC | 1,781,470 | 96,217,000 | 1.28% | ||
| 13 | OppenheimerFunds, Inc. | 1,400,000 | 75,614,000 | 1.00% | ||
| 14 | GOLDMAN SACHS GROUP INC | 1,350,318 | 72,931,000 | 0.97% | ||
| 15 | PINNACLE ASSOCIATES LTD | 1,166,413 | 62,998,000 | 0.84% | ||
| 16 | CITADEL ADVISORS LLC | 1,146,267 | 61,910,000 | 0.82% | ||
| 17 | DEUTSCHE BANK AG\ | 969,314 | 52,348,000 | 0.69% | ||
| 18 | Mitsubishi UFJ Trust & Banking Corp | 875,039 | 47,261,000 | 0.63% | ||
| 19 | EVENTIDE ASSET MANAGEMENT, LLC | 835,506 | 45,126,000 | 0.60% | ||
| 20 | NORGES BANK | 849,671 | 43,831,000 | 0.58% | ||
| 21 | FIRST TRUST ADVISORS LP | 747,389 | 40,366,000 | 0.54% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 723,348 | 39,067,000 | 0.52% | ||
| 23 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 682,974 | 36,887,000 | 0.49% | ||
| 24 | BLAIR WILLIAM & CO/IL | 669,458 | 36,157,000 | 0.48% | ||
| 25 | Lagoda Investment Management, L.P. | 567,057 | 30,627,000 | 0.41% | ||
| 26 | BANK OF AMERICA CORP /DE/ | 443,485 | 23,952,000 | 0.32% | ||
| 27 | NORTHERN TRUST CORP | 416,184 | 22,479,000 | 0.30% | ||
| 28 | Bank of New York Mellon Corp | 373,752 | 20,187,000 | 0.27% | ||
| 29 | BLACKROCK ADVISORS LLC | 370,627 | 20,018,000 | 0.27% | ||
| 30 | NEW YORK STATE COMMON RETIREMENT FUND | 353,061 | 19,069,000 | 0.25% | ||
| 31 | BALYASNY ASSET MANAGEMENT L.P. | 348,864 | 18,842,000 | 0.25% | ||
| 32 | LORD, ABBETT & CO. LLC | 344,174 | 18,589,000 | 0.25% | ||
| 33 | CREDIT SUISSE AG/ | 333,874 | 18,033,000 | 0.24% | ||
| 34 | THORNBURG INVESTMENT MANAGEMENT INC | 316,277 | 17,082,000 | 0.23% | ||
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 308,680 | 16,672,000 | 0.22% | ||
| 36 | MORGAN STANLEY | 263,587 | 14,236,000 | 0.19% | ||
| 37 | MANNING & NAPIER ADVISORS LLC | 257,580 | 13,910,000 | 0.18% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 245,344 | 13,252,000 | 0.18% | ||
| 39 | D. E. Shaw & Co., Inc. | 245,073 | 13,236,000 | 0.18% | ||
| 40 | BOXER CAPITAL, LLC | 232,600 | 12,563,000 | 0.17% | ||
| 41 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 221,200 | 11,947,000 | 0.16% | ||
| 42 | EMERALD ACQUISITION LTD. | 220,992 | 11,935,000 | 0.16% | ||
| 43 | ROYAL BANK OF CANADA | 205,238 | 11,085,000 | 0.15% | ||
| 44 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 205,207 | 11,083,000 | 0.15% | ||
| 45 | DIMENSIONAL FUND ADVISORS LP | 203,256 | 10,977,000 | 0.15% | ||
| 46 | Invesco Ltd. | 179,370 | 9,688,000 | 0.13% | ||
| 47 | STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 178,977 | 9,667,000 | 0.13% | ||
| 48 | Swiss National Bank | 170,400 | 9,203,000 | 0.12% | ||
| 49 | NF TRINITY CAPITAL (HONG KONG) LTD | 166,461 | 8,991,000 | 0.12% | ||
| 50 | BlackRock Group LTD | 165,936 | 8,962,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
