| 1 |
NEA Management Company, LLC |
3,811,691 |
29,960,000 |
25.02% |
|
|
| 2 |
Polaris Venture Management Co. V, L.L.C. |
3,811,682 |
29,960,000 |
25.02% |
|
|
| 3 |
WELLINGTON MANAGEMENT GROUP LLP |
1,105,455 |
8,689,000 |
7.25% |
|
|
| 4 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
800,000 |
6,288,000 |
5.25% |
|
|
| 5 |
Bain Capital Public Equity Management, LLC |
799,998 |
6,288,000 |
5.25% |
|
|
| 6 |
PERCEPTIVE ADVISORS LLC |
770,000 |
6,052,000 |
5.05% |
|
|
| 7 |
JPMORGAN CHASE & CO |
629,575 |
4,949,000 |
4.13% |
|
|
| 8 |
Broadfin Capital, LLC |
600,000 |
4,716,000 |
3.94% |
|
|
| 9 |
PUTNAM INVESTMENTS LLC |
556,184 |
4,372,000 |
3.65% |
|
|
| 10 |
Meiji Yasuda Life Insurance Co |
505,692 |
3,975,000 |
3.32% |
|
|
| 11 |
BVF INC/IL |
350,000 |
2,751,000 |
2.30% |
|
|
| 12 |
SPHERA FUNDS MANAGEMENT LTD. |
250,000 |
1,965,000 |
1.64% |
|
|
| 13 |
Alyeska Investment Group, L.P. |
236,126 |
1,856,000 |
1.55% |
|
|
| 14 |
BlackRock Fund Advisors |
172,750 |
1,358,000 |
1.13% |
|
|
| 15 |
VANGUARD GROUP INC |
135,620 |
1,066,000 |
0.89% |
|
|
| 16 |
BlackRock Institutional Trust Company, N.A. |
119,529 |
939,000 |
0.78% |
|
|
| 17 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
125,000 |
772,000 |
0.64% |
|
|
| 18 |
PANAGORA ASSET MANAGEMENT INC |
91,515 |
719,000 |
0.60% |
|
|
| 19 |
DEUTSCHE BANK AG\ |
59,658 |
468,000 |
0.39% |
|
|
| 20 |
STATE STREET CORP |
46,843 |
368,000 |
0.31% |
|
|
| 21 |
SAC Capital Advisors LP |
38,196 |
300,000 |
0.25% |
|
|
| 22 |
Nationwide Fund Advisors |
37,266 |
293,000 |
0.24% |
|
|
| 23 |
GEODE CAPITAL MANAGEMENT, LLC |
36,350 |
285,000 |
0.24% |
|
|
| 24 |
NORTHERN TRUST CORP |
34,717 |
273,000 |
0.23% |
|
|
| 25 |
BANQUE PICTET & CIE SA |
19,626 |
154,000 |
0.13% |
|
|
| 26 |
Spark Investment Management LLC |
17,800 |
140,000 |
0.12% |
|
|
| 27 |
BlackRock Investment Management, LLC |
16,826 |
132,000 |
0.11% |
|
|
| 28 |
NATIONAL PLANNING CORP |
15,475 |
118,000 |
0.10% |
|
|
| 29 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
13,400 |
105,000 |
0.09% |
|
|
| 30 |
TUDOR INVESTMENT CORP ET AL |
12,500 |
98,000 |
0.08% |
|
|
| 31 |
GOLDMAN SACHS GROUP INC |
11,038 |
87,000 |
0.07% |
|
|
| 32 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
10,100 |
79,000 |
0.07% |
|
|
| 33 |
TEACHERS ADVISORS, LLC |
7,490 |
59,000 |
0.05% |
|
|
| 34 |
MORGAN STANLEY |
6,351 |
50,000 |
0.04% |
|
|
| 35 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
6,400 |
50,000 |
0.04% |
|
|
| 36 |
AMERICAN INTERNATIONAL GROUP, INC. |
2,000 |
15,720 |
0.01% |
|
|
| 37 |
BLACKROCK ADVISORS LLC |
1,330 |
10,000 |
0.01% |
|
|
| 38 |
BANK OF AMERICA CORP /DE/ |
500 |
4,000 |
0.00% |
|
|
| 39 |
Tower Research Capital LLC (TRC) |
263 |
2,000 |
0.00% |
|
|
| 40 |
BARCLAYS PLC |
201 |
1,000 |
0.00% |
|
|
