| 1 |
NEA Management Company, LLC |
3,811,691 |
21,536,000 |
25.29% |
|
|
| 2 |
Polaris Venture Management Co. V, L.L.C. |
3,811,682 |
21,536,000 |
25.29% |
|
|
| 3 |
WELLINGTON MANAGEMENT GROUP LLP |
1,458,645 |
8,242,000 |
9.68% |
|
|
| 4 |
BVF INC/IL |
1,118,743 |
6,321,000 |
7.42% |
|
|
| 5 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
800,000 |
4,520,000 |
5.31% |
|
|
| 6 |
PERCEPTIVE ADVISORS LLC |
770,000 |
4,351,000 |
5.11% |
|
|
| 7 |
PUTNAM INVESTMENTS LLC |
606,931 |
3,429,000 |
4.03% |
|
|
| 8 |
Broadfin Capital, LLC |
600,000 |
3,390,000 |
3.98% |
|
|
| 9 |
Meiji Yasuda Life Insurance Co |
505,692 |
2,857,000 |
3.35% |
|
|
| 10 |
SPHERA FUNDS MANAGEMENT LTD. |
341,000 |
1,927,000 |
2.26% |
|
|
| 11 |
Alyeska Investment Group, L.P. |
225,782 |
1,276,000 |
1.50% |
|
|
| 12 |
JPMORGAN CHASE & CO |
137,300 |
776,000 |
0.91% |
|
|
| 13 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
125,000 |
706,000 |
0.83% |
|
|
| 14 |
VANGUARD GROUP INC |
123,841 |
700,000 |
0.82% |
|
|
| 15 |
PANAGORA ASSET MANAGEMENT INC |
87,188 |
493,000 |
0.58% |
|
|
| 16 |
BLACKROCK ADVISORS LLC |
74,176 |
419,000 |
0.49% |
|
|
| 17 |
NORTHERN TRUST CORP |
65,122 |
368,000 |
0.43% |
|
|
| 18 |
BlackRock Institutional Trust Company, N.A. |
56,902 |
321,000 |
0.38% |
|
|
| 19 |
DEUTSCHE BANK AG\ |
55,943 |
316,000 |
0.37% |
|
|
| 20 |
CITIZENS & NORTHERN CORP |
40,000 |
226,000 |
0.27% |
|
|
| 21 |
GEODE CAPITAL MANAGEMENT, LLC |
32,361 |
182,000 |
0.21% |
|
|
| 22 |
Paloma Partners Management Co |
31,629 |
179,000 |
0.21% |
|
|
| 23 |
BANK OF AMERICA CORP /DE/ |
30,189 |
171,000 |
0.20% |
|
|
| 24 |
BlackRock Group LTD |
25,972 |
147,000 |
0.17% |
|
|
| 25 |
BANQUE PICTET & CIE SA |
23,075 |
130,000 |
0.15% |
|
|
| 26 |
COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS |
21,099 |
119,000 |
0.14% |
|
|
| 27 |
LMR Partners LLP |
15,967 |
90,000 |
0.11% |
|
|
| 28 |
NATIONAL PLANNING CORP |
15,475 |
87,000 |
0.10% |
|
|
| 29 |
RUSSELL FRANK CO/ |
15,004 |
85,000 |
0.10% |
|
|
| 30 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
10,100 |
57,000 |
0.07% |
|
|
| 31 |
MILLENNIUM MANAGEMENT LLC |
10,145 |
57,000 |
0.07% |
|
|
| 32 |
GOLDMAN SACHS GROUP INC |
10,106 |
57,000 |
0.07% |
|
|
| 33 |
BARCLAYS PLC |
5,745 |
29,000 |
0.03% |
|
|
| 34 |
BlackRock Japan Co. Ltd |
4,787 |
27,000 |
0.03% |
|
|
| 35 |
MORGAN STANLEY |
4,340 |
25,000 |
0.03% |
|
|
| 36 |
BlackRock Investment Management, LLC |
1,305 |
7,000 |
0.01% |
|
|
| 37 |
AMERICAN INTERNATIONAL GROUP, INC. |
1,000 |
5,650 |
0.01% |
|
|
| 38 |
Ground Swell Capital, LLC |
601 |
3,000 |
0.00% |
|
|
| 39 |
BNP PARIBAS FINANCIAL MARKETS |
237 |
1,339 |
0.00% |
|
|
| 40 |
BANK OF MONTREAL /CAN/ |
190 |
1,000 |
0.00% |
|
|
| 41 |
Tower Research Capital LLC (TRC) |
140 |
1,000 |
0.00% |
|
|
| 42 |
CITIGROUP INC |
62 |
0 |
0.00% |
|
|
