| 1 |
FMR LLC |
4,834,721 |
30,265,000 |
17.18% |
|
|
| 2 |
NEA Management Company, LLC |
4,811,691 |
30,121,000 |
17.10% |
|
|
| 3 |
WELLINGTON MANAGEMENT GROUP LLP |
4,443,362 |
27,814,000 |
15.79% |
|
|
| 4 |
Polaris Venture Management Co. V, L.L.C. |
3,769,280 |
23,596,000 |
13.39% |
|
|
| 5 |
Broadfin Capital, LLC |
1,409,153 |
8,821,000 |
5.01% |
|
|
| 6 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
1,400,000 |
8,764,000 |
4.97% |
|
|
| 7 |
VANGUARD GROUP INC |
678,805 |
4,250,000 |
2.41% |
|
|
| 8 |
BlackRock Fund Advisors |
657,870 |
4,118,000 |
2.34% |
|
|
| 9 |
BlackRock Institutional Trust Company, N.A. |
646,597 |
4,048,000 |
2.30% |
|
|
| 10 |
PUTNAM INVESTMENTS LLC |
602,055 |
3,768,000 |
2.14% |
|
|
| 11 |
RA CAPITAL MANAGEMENT, L.P. |
528,118 |
3,306,000 |
1.88% |
|
|
| 12 |
SPHERA FUNDS MANAGEMENT LTD. |
410,000 |
2,567,000 |
1.46% |
|
|
| 13 |
Alyeska Investment Group, L.P. |
391,298 |
2,450,000 |
1.39% |
|
|
| 14 |
NORTHPOINTE CAPITAL LLC |
358,758 |
2,246,000 |
1.27% |
|
|
| 15 |
BLACKROCK ADVISORS LLC |
233,549 |
1,462,000 |
0.83% |
|
|
| 16 |
MORGAN STANLEY |
229,380 |
1,436,000 |
0.82% |
|
|
| 17 |
Nuveen Asset Management, LLC |
1,831 |
1,342,000 |
0.76% |
|
|
| 18 |
MILLENNIUM MANAGEMENT LLC |
206,064 |
1,290,000 |
0.73% |
|
|
| 19 |
TURNER INVESTMENTS LLC |
152,750 |
957,000 |
0.54% |
|
|
| 20 |
Connor, Clark & Lunn Investment Management Ltd. |
130,700 |
818,000 |
0.46% |
|
|
| 21 |
Granahan Investment Management, LLC |
125,950 |
788,000 |
0.45% |
|
|
| 22 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
125,000 |
783,000 |
0.44% |
|
|
| 23 |
BOGLE INVESTMENT MANAGEMENT L P /DE/ |
123,614 |
773,000 |
0.44% |
|
|
| 24 |
GEODE CAPITAL MANAGEMENT, LLC |
123,371 |
772,000 |
0.44% |
|
|
| 25 |
RENAISSANCE TECHNOLOGIES LLC |
119,300 |
747,000 |
0.42% |
|
|
| 26 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
102,017 |
639,000 |
0.36% |
|
|
| 27 |
TFS CAPITAL LLC |
92,505 |
579,000 |
0.33% |
|
|
| 28 |
Bank of New York Mellon Corp |
92,450 |
579,000 |
0.33% |
|
|
| 29 |
BlackRock Investment Management, LLC |
84,267 |
528,000 |
0.30% |
|
|
| 30 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
83,799 |
525,000 |
0.30% |
|
|
| 31 |
Spark Investment Management LLC |
76,900 |
480,000 |
0.27% |
|
|
| 32 |
Numeric Investors LLC |
76,418 |
478,000 |
0.27% |
|
|
| 33 |
PDT Partners, LLC |
74,835 |
468,000 |
0.27% |
|
|
| 34 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
68,580 |
429,000 |
0.24% |
|
|
| 35 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
57,337 |
359,000 |
0.20% |
|
|
| 36 |
BlackRock Group LTD |
49,285 |
309,000 |
0.18% |
|
|
| 37 |
NORTHERN TRUST CORP |
48,839 |
306,000 |
0.17% |
|
|
| 38 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
45,226 |
283,000 |
0.16% |
|
|
| 39 |
ALPS ADVISORS INC |
39,071 |
245,000 |
0.14% |
|
|
| 40 |
TEACHERS ADVISORS, LLC |
36,702 |
230,000 |
0.13% |
|
|
| 41 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
35,334 |
222,000 |
0.13% |
|
|
| 42 |
EAGLE GLOBAL ADVISORS LLC |
32,640 |
204,000 |
0.12% |
|
|
| 43 |
AQR CAPITAL MANAGEMENT LLC |
27,642 |
173,000 |
0.10% |
|
|
| 44 |
PANAGORA ASSET MANAGEMENT INC |
22,669 |
142,000 |
0.08% |
|
|
| 45 |
A.R.T. Advisors, LLC |
22,173 |
138,000 |
0.08% |
|
|
| 46 |
GOLDMAN SACHS GROUP INC |
21,720 |
136,000 |
0.08% |
|
|
| 47 |
RHUMBLINE ADVISERS |
19,920 |
125,000 |
0.07% |
|
|
| 48 |
CITIZENS & NORTHERN CORP |
20,000 |
125,000 |
0.07% |
|
|
| 49 |
NEW YORK STATE COMMON RETIREMENT FUND |
16,680 |
104,000 |
0.06% |
|
|
| 50 |
Nationwide Fund Advisors |
15,605 |
98,000 |
0.06% |
|
|
