| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 7,585,183 | 62,730,000 | 19.49% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 5,714,773 | 47,262,000 | 14.69% | ||
| 3 | NEA Management Company, LLC | 3,811,691 | 31,523,000 | 9.80% | ||
| 4 | Polaris Venture Management Co. V, L.L.C. | 2,669,280 | 22,075,000 | 6.86% | ||
| 5 | BALYASNY ASSET MANAGEMENT L.P. | 1,622,550 | 13,418,000 | 4.17% | ||
| 6 | MILLENNIUM MANAGEMENT LLC | 1,588,513 | 13,137,000 | 4.08% | ||
| 7 | BlackRock Fund Advisors | 1,484,010 | 12,273,000 | 3.81% | ||
| 8 | VANGUARD GROUP INC | 1,228,164 | 10,157,000 | 3.16% | ||
| 9 | VIVO CAPITAL, LLC | 1,200,000 | 9,924,000 | 3.08% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 989,829 | 8,186,000 | 2.54% | ||
| 11 | Broadfin Capital, LLC | 812,579 | 6,720,000 | 2.09% | ||
| 12 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 785,000 | 6,492,000 | 2.02% | ||
| 13 | JENNISON ASSOCIATES LLC | 707,262 | 5,849,000 | 1.82% | ||
| 14 | CITIGROUP INC | 631,002 | 5,219,000 | 1.62% | ||
| 15 | PUTNAM INVESTMENTS LLC | 605,276 | 5,006,000 | 1.56% | ||
| 16 | DEUTSCHE BANK AG\ | 534,617 | 4,419,000 | 1.37% | ||
| 17 | CITADEL ADVISORS LLC | 501,792 | 4,150,000 | 1.29% | ||
| 18 | BAKER BROS. ADVISORS LP | 450,000 | 3,722,000 | 1.16% | ||
| 19 | Numeric Investors LLC | 419,857 | 3,472,000 | 1.08% | ||
| 20 | Granahan Investment Management, LLC | 416,369 | 3,443,000 | 1.07% | ||
| 21 | STATE STREET CORP | 412,015 | 3,407,000 | 1.06% | ||
| 22 | Informed Momentum Co LLC | 403,185 | 3,334,000 | 1.04% | ||
| 23 | NORTHERN TRUST CORP | 353,302 | 2,922,000 | 0.91% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 251,486 | 2,079,000 | 0.65% | ||
| 25 | Bank of New York Mellon Corp | 242,305 | 2,004,000 | 0.62% | ||
| 26 | MARSHALL WACE, LLP | 221,502 | 1,832,000 | 0.57% | ||
| 27 | NORTHPOINTE CAPITAL LLC | 196,925 | 1,629,000 | 0.51% | ||
| 28 | AMERIPRISE FINANCIAL INC | 196,116 | 1,622,000 | 0.50% | ||
| 29 | QS Investors, LLC | 177,483 | 1,468,000 | 0.46% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 172,319 | 1,425,000 | 0.44% | ||
| 31 | Connor, Clark & Lunn Investment Management Ltd. | 161,305 | 1,334,000 | 0.41% | ||
| 32 | Candriam S.C.A. | 160,000 | 1,316,000 | 0.41% | ||
| 33 | TURNER INVESTMENTS LLC | 147,920 | 1,224,000 | 0.38% | ||
| 34 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 143,150 | 1,184,000 | 0.37% | ||
| 35 | BLACKROCK ADVISORS LLC | 129,827 | 1,074,000 | 0.33% | ||
| 36 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 125,000 | 1,034,000 | 0.32% | ||
| 37 | BlackRock Investment Management, LLC | 114,460 | 947,000 | 0.29% | ||
| 38 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 112,316 | 929,000 | 0.29% | ||
| 39 | RUSSELL FRANK CO/ | 112,257 | 928,000 | 0.29% | ||
| 40 | TFS CAPITAL LLC | 79,837 | 660,000 | 0.21% | ||
| 41 | Invesco Ltd. | 76,699 | 634,000 | 0.20% | ||
| 42 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 64,248 | 531,000 | 0.17% | ||
| 43 | Nationwide Fund Advisors | 61,155 | 506,000 | 0.16% | ||
| 44 | TEACHERS ADVISORS, LLC | 59,771 | 494,000 | 0.15% | ||
| 45 | ALPS ADVISORS INC | 57,125 | 472,000 | 0.15% | ||
| 46 | Swiss National Bank | 56,000 | 448,000 | 0.14% | ||
| 47 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 50,234 | 416,000 | 0.13% | ||
| 48 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 45,400 | 375,000 | 0.12% | ||
| 49 | CREDIT SUISSE AG/ | 42,046 | 348,000 | 0.11% | ||
| 50 | ProShare Advisors LLC | 41,488 | 343,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
