| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 7,326,898 | 43,082,000 | 17.87% | ||
| 2 | FMR LLC | 6,733,548 | 39,594,000 | 16.42% | ||
| 3 | NEA Management Company, LLC | 3,811,691 | 22,413,000 | 9.29% | ||
| 4 | GREAT POINT PARTNERS LLC | 3,000,650 | 17,644,000 | 7.32% | ||
| 5 | BALYASNY ASSET MANAGEMENT L.P. | 2,308,046 | 13,571,000 | 5.63% | ||
| 6 | BlackRock Fund Advisors | 2,159,505 | 12,698,000 | 5.27% | ||
| 7 | Polaris Venture Management Co. V, L.L.C. | 2,053,540 | 12,075,000 | 5.01% | ||
| 8 | VIVO CAPITAL, LLC | 1,728,000 | 10,161,000 | 4.21% | ||
| 9 | VANGUARD GROUP INC | 1,475,523 | 8,676,000 | 3.60% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 1,295,442 | 7,617,000 | 3.16% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 1,014,704 | 5,966,000 | 2.47% | ||
| 12 | STATE STREET CORP | 706,305 | 4,154,000 | 1.72% | ||
| 13 | JENNISON ASSOCIATES LLC | 705,902 | 4,151,000 | 1.72% | ||
| 14 | NORTHERN TRUST CORP | 496,262 | 2,919,000 | 1.21% | ||
| 15 | BAKER BROS. ADVISORS LP | 450,000 | 2,646,000 | 1.10% | ||
| 16 | PUTNAM INVESTMENTS LLC | 430,954 | 2,534,000 | 1.05% | ||
| 17 | NORTHPOINTE CAPITAL LLC | 430,819 | 2,533,000 | 1.05% | ||
| 18 | NEXTHERA CAPITAL LP | 398,849 | 2,345,000 | 0.97% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 374,590 | 2,202,000 | 0.91% | ||
| 20 | HARBOURVEST PARTNERS LLC | 311,650 | 1,833,000 | 0.76% | ||
| 21 | TIAA CREF INVESTMENT MANAGEMENT LLC | 223,635 | 1,315,000 | 0.55% | ||
| 22 | PRICE T ROWE ASSOCIATES INC /MD/ | 201,556 | 1,185,000 | 0.49% | ||
| 23 | AWM Investment Company, Inc. | 200,000 | 1,176,000 | 0.49% | ||
| 24 | BlackRock Investment Management, LLC | 174,245 | 1,025,000 | 0.43% | ||
| 25 | QS Investors, LLC | 173,811 | 1,022,000 | 0.42% | ||
| 26 | Bank of New York Mellon Corp | 164,976 | 969,000 | 0.40% | ||
| 27 | WELLS FARGO & COMPANY/MN | 160,699 | 945,000 | 0.39% | ||
| 28 | Candriam S.C.A. | 160,000 | 941,000 | 0.39% | ||
| 29 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 156,843 | 922,000 | 0.38% | ||
| 30 | DEUTSCHE BANK AG\ | 147,290 | 864,000 | 0.36% | ||
| 31 | MORGAN STANLEY | 134,037 | 788,000 | 0.33% | ||
| 32 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 127,334 | 749,000 | 0.31% | ||
| 33 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 125,000 | 735,000 | 0.30% | ||
| 34 | Numeric Investors LLC | 108,900 | 640,000 | 0.27% | ||
| 35 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 92,107 | 542,000 | 0.22% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 87,285 | 513,000 | 0.21% | ||
| 37 | RUSSELL INVESTMENTS GROUP, LTD. | 82,355 | 483,000 | 0.20% | ||
| 38 | B. Riley Wealth Advisors, Inc. | 78,550 | 462,000 | 0.19% | ||
| 39 | TEACHERS ADVISORS, LLC | 77,523 | 456,000 | 0.19% | ||
| 40 | Piermont Capital Management Inc. | 76,870 | 452,000 | 0.19% | ||
| 41 | BLACKROCK ADVISORS LLC | 75,298 | 443,000 | 0.18% | ||
| 42 | JPMORGAN CHASE & CO | 61,635 | 362,000 | 0.15% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 56,400 | 332,000 | 0.14% | Put | |
| 44 | Swiss National Bank | 56,000 | 329,000 | 0.14% | ||
| 45 | CREDIT SUISSE AG/ | 54,360 | 319,000 | 0.13% | ||
| 46 | GOLDMAN SACHS GROUP INC | 53,120 | 312,000 | 0.13% | ||
| 47 | NEW YORK STATE COMMON RETIREMENT FUND | 50,890 | 299,000 | 0.12% | ||
| 48 | RHUMBLINE ADVISERS | 45,923 | 270,000 | 0.11% | ||
| 49 | ProShare Advisors LLC | 41,762 | 246,000 | 0.10% | ||
| 50 | GUGGENHEIM CAPITAL LLC | 40,988 | 241,000 | 0.10% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
