| 1 |
WELLINGTON MANAGEMENT GROUP LLP |
5,244,202 |
31,360,000 |
20.06% |
|
|
| 2 |
NEA Management Company, LLC |
4,811,691 |
28,774,000 |
18.40% |
|
|
| 3 |
Polaris Venture Management Co. V, L.L.C. |
3,769,280 |
22,540,000 |
14.41% |
|
|
| 4 |
RA CAPITAL MANAGEMENT, L.P. |
2,974,647 |
17,788,000 |
11.38% |
|
|
| 5 |
Camber Capital Management LP |
2,870,000 |
17,163,000 |
10.98% |
|
|
| 6 |
Broadfin Capital, LLC |
1,409,153 |
8,427,000 |
5.39% |
|
|
| 7 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
1,400,000 |
8,372,000 |
5.35% |
|
|
| 8 |
Alyeska Investment Group, L.P. |
743,114 |
4,444,000 |
2.84% |
|
|
| 9 |
PUTNAM INVESTMENTS LLC |
606,698 |
3,628,000 |
2.32% |
|
|
| 10 |
SPHERA FUNDS MANAGEMENT LTD. |
549,811 |
3,288,000 |
2.10% |
|
|
| 11 |
DAFNA Capital Management LLC |
280,000 |
1,674,000 |
1.07% |
|
|
| 12 |
NORTHPOINTE CAPITAL LLC |
207,418 |
1,240,000 |
0.79% |
|
|
| 13 |
BLACKROCK ADVISORS LLC |
204,079 |
1,220,000 |
0.78% |
|
|
| 14 |
VANGUARD GROUP INC |
200,284 |
1,198,000 |
0.77% |
|
|
| 15 |
DEUTSCHE BANK AG\ |
151,715 |
906,000 |
0.58% |
|
|
| 16 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
125,000 |
716,000 |
0.46% |
|
|
| 17 |
BlackRock Institutional Trust Company, N.A. |
104,682 |
626,000 |
0.40% |
|
|
| 18 |
COMMONWEALTH BANK OF AUSTRALIA |
96,500 |
577,000 |
0.37% |
|
|
| 19 |
GEODE CAPITAL MANAGEMENT, LLC |
66,070 |
395,000 |
0.25% |
|
|
| 20 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
62,180 |
372,000 |
0.24% |
|
|
| 21 |
MILLENNIUM MANAGEMENT LLC |
56,599 |
338,000 |
0.22% |
|
|
| 22 |
CITIZENS & NORTHERN CORP |
40,000 |
239,000 |
0.15% |
|
|
| 23 |
NORTHERN TRUST CORP |
28,870 |
173,000 |
0.11% |
|
|
| 24 |
TFS CAPITAL LLC |
27,518 |
165,000 |
0.11% |
|
|
| 25 |
BlackRock Fund Advisors |
18,448 |
110,000 |
0.07% |
|
|
| 26 |
Connor, Clark & Lunn Investment Management Ltd. |
17,300 |
103,000 |
0.07% |
|
|
| 27 |
NATIONAL PLANNING CORP |
15,475 |
84,803 |
0.05% |
|
|
| 28 |
BANQUE PICTET & CIE SA |
13,890 |
83,000 |
0.05% |
|
|
| 29 |
BlackRock Group LTD |
13,071 |
78,000 |
0.05% |
|
|
| 30 |
Spark Investment Management LLC |
12,800 |
76,000 |
0.05% |
|
|
| 31 |
Cubist Systematic Strategies, LLC |
10,011 |
60,000 |
0.04% |
|
|
| 32 |
GOLDMAN SACHS GROUP INC |
10,023 |
60,000 |
0.04% |
|
|
| 33 |
BlackRock Japan Co. Ltd |
7,177 |
43,000 |
0.03% |
|
|
| 34 |
MORGAN STANLEY |
4,800 |
29,000 |
0.02% |
|
|
| 35 |
BlackRock Investment Management, LLC |
1,829 |
11,000 |
0.01% |
|
|
| 36 |
BANK OF AMERICA CORP /DE/ |
500 |
3,000 |
0.00% |
|
|
| 37 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
252 |
2,000 |
0.00% |
|
|
| 38 |
CITIGROUP INC |
100 |
1,000 |
0.00% |
|
|
