| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 7,817,748 | 52,770,000 | 20.10% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 5,748,969 | 38,805,000 | 14.78% | ||
| 3 | NEA Management Company, LLC | 3,811,691 | 25,729,000 | 9.80% | ||
| 4 | Polaris Venture Management Co. V, L.L.C. | 2,053,540 | 13,861,000 | 5.28% | ||
| 5 | BlackRock Fund Advisors | 1,936,501 | 13,071,000 | 4.98% | ||
| 6 | BALYASNY ASSET MANAGEMENT L.P. | 1,805,000 | 12,184,000 | 4.64% | ||
| 7 | VIVO CAPITAL, LLC | 1,728,000 | 11,664,000 | 4.44% | ||
| 8 | VANGUARD GROUP INC | 1,418,137 | 9,573,000 | 3.65% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 1,088,012 | 7,344,000 | 2.80% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 989,828 | 6,681,000 | 2.55% | ||
| 11 | NORTHPOINTE CAPITAL LLC | 716,102 | 4,834,000 | 1.84% | ||
| 12 | JENNISON ASSOCIATES LLC | 703,851 | 4,751,000 | 1.81% | ||
| 13 | STATE STREET CORP | 679,685 | 4,589,000 | 1.75% | ||
| 14 | PUTNAM INVESTMENTS LLC | 578,349 | 3,904,000 | 1.49% | ||
| 15 | CITADEL ADVISORS LLC | 553,828 | 3,738,000 | 1.42% | ||
| 16 | Broadfin Capital, LLC | 492,000 | 3,321,000 | 1.27% | ||
| 17 | NORTHERN TRUST CORP | 472,635 | 3,190,000 | 1.22% | ||
| 18 | BAKER BROS. ADVISORS LP | 450,000 | 3,038,000 | 1.16% | ||
| 19 | GOLDMAN SACHS GROUP INC | 430,855 | 2,908,000 | 1.11% | ||
| 20 | DEUTSCHE BANK AG\ | 369,635 | 2,494,000 | 0.95% | ||
| 21 | CITIGROUP INC | 367,674 | 2,481,000 | 0.95% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 339,785 | 2,293,000 | 0.87% | ||
| 23 | HARBOURVEST PARTNERS LLC | 311,650 | 2,104,000 | 0.80% | ||
| 24 | NEXTHERA CAPITAL LP | 298,849 | 2,017,000 | 0.77% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 239,573 | 1,617,000 | 0.62% | ||
| 26 | PRICE T ROWE ASSOCIATES INC /MD/ | 209,208 | 1,412,000 | 0.54% | ||
| 27 | QS Investors, LLC | 177,483 | 1,198,000 | 0.46% | ||
| 28 | BlackRock Investment Management, LLC | 172,290 | 1,163,000 | 0.44% | ||
| 29 | Bank of New York Mellon Corp | 170,026 | 1,148,000 | 0.44% | ||
| 30 | Granahan Investment Management, LLC | 161,044 | 1,087,000 | 0.41% | ||
| 31 | Candriam S.C.A. | 160,000 | 1,080,000 | 0.41% | ||
| 32 | AWM Investment Company, Inc. | 143,904 | 971,000 | 0.37% | ||
| 33 | TURNER INVESTMENTS LLC | 138,800 | 937,000 | 0.36% | ||
| 34 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 134,390 | 907,000 | 0.35% | ||
| 35 | BLACKROCK ADVISORS LLC | 127,865 | 863,000 | 0.33% | ||
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 127,334 | 860,000 | 0.33% | ||
| 37 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 125,000 | 844,000 | 0.32% | ||
| 38 | TFS CAPITAL LLC | 103,874 | 701,000 | 0.27% | ||
| 39 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 94,707 | 639,000 | 0.24% | ||
| 40 | CREDIT SUISSE AG/ | 92,149 | 623,000 | 0.24% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 86,000 | 581,000 | 0.22% | Call | |
| 42 | EMERALD ACQUISITION LTD. | 82,355 | 556,000 | 0.21% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 81,600 | 551,000 | 0.21% | Put | |
| 44 | Piermont Capital Management Inc. | 78,350 | 529,000 | 0.20% | ||
| 45 | TEACHERS ADVISORS, LLC | 73,018 | 493,000 | 0.19% | ||
| 46 | ALPS ADVISORS INC | 66,518 | 449,000 | 0.17% | ||
| 47 | Swiss National Bank | 56,000 | 378,000 | 0.14% | ||
| 48 | NEW YORK STATE COMMON RETIREMENT FUND | 50,890 | 344,000 | 0.13% | ||
| 49 | BARCLAYS PLC | 48,405 | 327,000 | 0.12% | ||
| 50 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 47,389 | 320,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
