| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 7,753,948 | 48,850,000 | 19.68% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 5,847,792 | 36,840,000 | 14.84% | ||
| 3 | NEA Management Company, LLC | 3,811,691 | 24,014,000 | 9.68% | ||
| 4 | Polaris Venture Management Co. V, L.L.C. | 2,270,319 | 14,303,000 | 5.76% | ||
| 5 | BlackRock Fund Advisors | 1,834,099 | 11,555,000 | 4.66% | ||
| 6 | VIVO CAPITAL, LLC | 1,728,000 | 10,886,000 | 4.39% | ||
| 7 | BALYASNY ASSET MANAGEMENT L.P. | 1,705,610 | 10,745,000 | 4.33% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 1,634,203 | 10,295,000 | 4.15% | ||
| 9 | VANGUARD GROUP INC | 1,381,542 | 8,703,000 | 3.51% | ||
| 10 | CITADEL ADVISORS LLC | 1,160,840 | 7,314,000 | 2.95% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 971,130 | 6,118,000 | 2.46% | ||
| 12 | JENNISON ASSOCIATES LLC | 706,560 | 4,451,000 | 1.79% | ||
| 13 | STATE STREET CORP | 692,685 | 4,365,000 | 1.76% | ||
| 14 | PUTNAM INVESTMENTS LLC | 499,000 | 3,144,000 | 1.27% | ||
| 15 | Broadfin Capital, LLC | 492,000 | 3,100,000 | 1.25% | ||
| 16 | NORTHERN TRUST CORP | 477,411 | 3,008,000 | 1.21% | ||
| 17 | BAKER BROS. ADVISORS LP | 450,000 | 2,835,000 | 1.14% | ||
| 18 | NORTHPOINTE CAPITAL LLC | 379,186 | 2,389,000 | 0.96% | ||
| 19 | DEUTSCHE BANK AG\ | 377,264 | 2,376,000 | 0.96% | ||
| 20 | CITIGROUP INC | 375,712 | 2,367,000 | 0.95% | ||
| 21 | HARBOURVEST PARTNERS LLC | 375,559 | 2,366,000 | 0.95% | ||
| 22 | Granahan Investment Management, LLC | 259,089 | 1,632,000 | 0.66% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 245,484 | 1,546,000 | 0.62% | ||
| 24 | JPMORGAN CHASE & CO | 228,439 | 1,439,000 | 0.58% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 224,097 | 1,412,000 | 0.57% | ||
| 26 | PRICE T ROWE ASSOCIATES INC /MD/ | 202,174 | 1,274,000 | 0.51% | ||
| 27 | QS Investors, LLC | 177,483 | 1,118,000 | 0.45% | ||
| 28 | Bank of New York Mellon Corp | 175,205 | 1,103,000 | 0.44% | ||
| 29 | BlackRock Investment Management, LLC | 172,617 | 1,087,000 | 0.44% | ||
| 30 | Candriam S.C.A. | 160,000 | 1,008,000 | 0.41% | ||
| 31 | NEXTHERA CAPITAL LP | 150,000 | 945,000 | 0.38% | ||
| 32 | AWM Investment Company, Inc. | 143,904 | 907,000 | 0.37% | ||
| 33 | TURNER INVESTMENTS LLC | 138,800 | 875,000 | 0.35% | ||
| 34 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 136,180 | 858,000 | 0.35% | ||
| 35 | BLACKROCK ADVISORS LLC | 130,039 | 819,000 | 0.33% | ||
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 127,334 | 803,000 | 0.32% | ||
| 37 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 125,000 | 788,000 | 0.32% | ||
| 38 | FIRST MANHATTAN CO. LLC. | 115,800 | 729,000 | 0.29% | ||
| 39 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 93,807 | 591,000 | 0.24% | ||
| 40 | Numeric Investors LLC | 81,656 | 514,000 | 0.21% | ||
| 41 | CREDIT SUISSE AG/ | 73,980 | 467,000 | 0.19% | ||
| 42 | ALPS ADVISORS INC | 73,294 | 462,000 | 0.19% | ||
| 43 | TEACHERS ADVISORS, LLC | 73,018 | 460,000 | 0.19% | ||
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 69,600 | 438,000 | 0.18% | Put | |
| 45 | Nationwide Fund Advisors | 69,297 | 437,000 | 0.18% | ||
| 46 | Swiss National Bank | 56,000 | 353,000 | 0.14% | ||
| 47 | GSA CAPITAL PARTNERS LLP | 54,582 | 344,000 | 0.14% | ||
| 48 | Trexquant Investment LP | 46,401 | 292,000 | 0.12% | ||
| 49 | BARCLAYS PLC | 46,069 | 290,000 | 0.12% | ||
| 50 | ProShare Advisors LLC | 44,312 | 279,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
