| 1 |
WELLINGTON MANAGEMENT GROUP LLP |
5,153,265 |
33,599,000 |
20.39% |
|
|
| 2 |
NEA Management Company, LLC |
4,811,691 |
31,372,000 |
19.04% |
|
|
| 3 |
Polaris Venture Management Co. V, L.L.C. |
3,769,280 |
24,576,000 |
14.91% |
|
|
| 4 |
Camber Capital Management LP |
2,870,000 |
18,712,000 |
11.35% |
|
|
| 5 |
Broadfin Capital, LLC |
1,409,153 |
9,188,000 |
5.57% |
|
|
| 6 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
1,400,000 |
9,128,000 |
5.54% |
|
|
| 7 |
RA CAPITAL MANAGEMENT, L.P. |
1,325,407 |
8,642,000 |
5.24% |
|
|
| 8 |
PUTNAM INVESTMENTS LLC |
602,868 |
3,931,000 |
2.39% |
|
|
| 9 |
VANGUARD GROUP INC |
529,143 |
3,450,000 |
2.09% |
|
|
| 10 |
SPHERA FUNDS MANAGEMENT LTD. |
391,811 |
2,555,000 |
1.55% |
|
|
| 11 |
Alyeska Investment Group, L.P. |
384,960 |
2,510,000 |
1.52% |
|
|
| 12 |
BlackRock Institutional Trust Company, N.A. |
342,380 |
2,232,000 |
1.35% |
|
|
| 13 |
BLACKROCK ADVISORS LLC |
323,057 |
2,106,000 |
1.28% |
|
|
| 14 |
NORTHPOINTE CAPITAL LLC |
285,538 |
1,862,000 |
1.13% |
|
|
| 15 |
MORGAN STANLEY |
144,947 |
944,000 |
0.57% |
|
|
| 16 |
RENAISSANCE TECHNOLOGIES LLC |
134,478 |
877,000 |
0.53% |
|
|
| 17 |
BOGLE INVESTMENT MANAGEMENT L P /DE/ |
113,611 |
740,000 |
0.45% |
|
|
| 18 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
125,000 |
716,000 |
0.43% |
|
|
| 19 |
GEODE CAPITAL MANAGEMENT, LLC |
101,140 |
659,000 |
0.40% |
|
|
| 20 |
Spark Investment Management LLC |
76,900 |
501,000 |
0.30% |
|
|
| 21 |
Numeric Investors LLC |
74,818 |
488,000 |
0.30% |
|
|
| 22 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
67,000 |
437,000 |
0.27% |
|
|
| 23 |
MILLENNIUM MANAGEMENT LLC |
63,521 |
414,000 |
0.25% |
|
|
| 24 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
57,337 |
374,000 |
0.23% |
|
|
| 25 |
TFS CAPITAL LLC |
55,116 |
359,000 |
0.22% |
|
|
| 26 |
PANAGORA ASSET MANAGEMENT INC |
54,895 |
358,000 |
0.22% |
|
|
| 27 |
DEUTSCHE BANK AG\ |
52,417 |
341,000 |
0.21% |
|
|
| 28 |
Connor, Clark & Lunn Investment Management Ltd. |
49,900 |
325,000 |
0.20% |
|
|
| 29 |
CREDIT SUISSE AG/ |
48,212 |
314,000 |
0.19% |
|
|
| 30 |
Rotella Capital Management, Inc. |
47,700 |
311,000 |
0.19% |
|
|
| 31 |
BlueCrest Capital Management Ltd |
47,315 |
308,000 |
0.19% |
|
|
| 32 |
TWO SIGMA INVESTMENTS, LP |
38,805 |
253,000 |
0.15% |
|
|
| 33 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
37,581 |
245,000 |
0.15% |
|
|
| 34 |
NORTHERN TRUST CORP |
34,181 |
223,000 |
0.14% |
|
|
| 35 |
BNP Paribas Asset Management Holding S.A. |
33,370 |
218,000 |
0.13% |
|
|
| 36 |
GOLDMAN SACHS GROUP INC |
32,015 |
209,000 |
0.13% |
|
|
| 37 |
BlackRock Group LTD |
30,922 |
202,000 |
0.12% |
|
|
| 38 |
BlackRock Fund Advisors |
30,597 |
199,000 |
0.12% |
|
|
| 39 |
PDT Partners, LLC |
25,100 |
164,000 |
0.10% |
|
|
| 40 |
Bank of New York Mellon Corp |
22,871 |
149,000 |
0.09% |
|
|
| 41 |
CITIZENS & NORTHERN CORP |
20,000 |
130,000 |
0.08% |
|
|
| 42 |
STATE STREET CORP |
16,800 |
110,000 |
0.07% |
|
|
| 43 |
NATIONAL PLANNING CORP |
15,475 |
100,000 |
0.06% |
|
|
| 44 |
Airain ltd |
14,136 |
92,000 |
0.06% |
|
|
| 45 |
Virtu KCG Holdings LLC |
11,213 |
73,000 |
0.04% |
|
|
| 46 |
BlackRock Japan Co. Ltd |
5,919 |
39,000 |
0.02% |
|
|
| 47 |
TURNER INVESTMENTS LLC |
3,000 |
20,000 |
0.01% |
|
|
| 48 |
WELLS FARGO & COMPANY/MN |
2,901 |
19,000 |
0.01% |
|
|
| 49 |
PNC FINANCIAL SERVICES GROUP, INC. |
2,000 |
13,000 |
0.01% |
|
|
| 50 |
BlackRock Investment Management, LLC |
1,829 |
12,000 |
0.01% |
|
|
