| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 7,284,026 | 75,390,000 | 19.40% | ||
| 2 | NEA Management Company, LLC | 4,811,691 | 49,801,000 | 12.81% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 4,256,876 | 44,059,000 | 11.34% | ||
| 4 | Polaris Venture Management Co. V, L.L.C. | 2,669,280 | 27,627,000 | 7.11% | ||
| 5 | MILLENNIUM MANAGEMENT LLC | 1,816,632 | 18,802,000 | 4.84% | ||
| 6 | BALYASNY ASSET MANAGEMENT L.P. | 1,420,760 | 14,705,000 | 3.78% | ||
| 7 | Broadfin Capital, LLC | 1,078,132 | 11,159,000 | 2.87% | ||
| 8 | VANGUARD GROUP INC | 1,026,650 | 10,626,000 | 2.73% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 993,280 | 10,280,000 | 2.65% | ||
| 10 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 871,877 | 9,023,000 | 2.32% | ||
| 11 | BlackRock Fund Advisors | 821,825 | 8,506,000 | 2.19% | ||
| 12 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 800,000 | 8,280,000 | 2.13% | ||
| 13 | ALPS ADVISORS INC | 77,577 | 8,029,000 | 2.07% | ||
| 14 | JENNISON ASSOCIATES LLC | 700,000 | 7,245,000 | 1.86% | ||
| 15 | PUTNAM INVESTMENTS LLC | 605,071 | 6,263,000 | 1.61% | ||
| 16 | CITADEL ADVISORS LLC | 591,868 | 6,126,000 | 1.58% | ||
| 17 | CITIGROUP INC | 580,206 | 6,005,000 | 1.55% | ||
| 18 | RENAISSANCE TECHNOLOGIES LLC | 456,200 | 4,722,000 | 1.21% | ||
| 19 | BAKER BROS. ADVISORS LP | 450,000 | 4,658,000 | 1.20% | ||
| 20 | Alyeska Investment Group, L.P. | 405,915 | 4,201,000 | 1.08% | ||
| 21 | Granahan Investment Management, LLC | 377,137 | 3,903,000 | 1.00% | ||
| 22 | MORGAN STANLEY | 316,516 | 3,275,000 | 0.84% | ||
| 23 | Informed Momentum Co LLC | 288,418 | 2,985,000 | 0.77% | ||
| 24 | NORTHERN TRUST CORP | 268,416 | 2,778,000 | 0.71% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 231,670 | 2,397,000 | 0.62% | ||
| 26 | DEUTSCHE BANK AG\ | 210,776 | 2,179,000 | 0.56% | ||
| 27 | TFS CAPITAL LLC | 202,907 | 2,100,000 | 0.54% | ||
| 28 | Connor, Clark & Lunn Investment Management Ltd. | 187,405 | 1,940,000 | 0.50% | ||
| 29 | Nine Chapters Capital Management LLC | 183,100 | 1,895,000 | 0.49% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 174,409 | 1,805,000 | 0.46% | ||
| 31 | Bank of New York Mellon Corp | 163,012 | 1,687,000 | 0.43% | ||
| 32 | Spark Investment Management LLC | 146,200 | 1,513,000 | 0.39% | ||
| 33 | NORTHPOINTE CAPITAL LLC | 139,278 | 1,442,000 | 0.37% | ||
| 34 | AMERIPRISE FINANCIAL INC | 136,247 | 1,410,000 | 0.36% | ||
| 35 | BLACKROCK ADVISORS LLC | 135,108 | 1,398,000 | 0.36% | ||
| 36 | JACOBS LEVY EQUITY MANAGEMENT, INC | 131,439 | 1,360,000 | 0.35% | ||
| 37 | RUSSELL FRANK CO/ | 125,311 | 1,297,000 | 0.33% | ||
| 38 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 125,000 | 1,294,000 | 0.33% | ||
| 39 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 114,878 | 1,189,000 | 0.31% | ||
| 40 | BlackRock Investment Management, LLC | 108,052 | 1,118,000 | 0.29% | ||
| 41 | SMITH ASSET MANAGEMENT GROUP LP | 103,370 | 1,070,000 | 0.28% | ||
| 42 | CREDIT SUISSE AG/ | 102,628 | 1,062,000 | 0.27% | ||
| 43 | Atika Capital Management LLC | 95,000 | 984,000 | 0.25% | ||
| 44 | AQR CAPITAL MANAGEMENT LLC | 78,266 | 810,000 | 0.21% | ||
| 45 | PDT Partners, LLC | 78,209 | 809,000 | 0.21% | ||
| 46 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 75,257 | 779,000 | 0.20% | ||
| 47 | TWO SIGMA INVESTMENTS, LP | 63,524 | 657,000 | 0.17% | ||
| 48 | Nationwide Fund Advisors | 60,553 | 627,000 | 0.16% | ||
| 49 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 58,026 | 601,000 | 0.15% | ||
| 50 | Candriam S.C.A. | 57,400 | 594,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
