| 1 |
NEA Management Company, LLC |
3,811,691 |
24,471,000 |
25.52% |
|
|
| 2 |
Polaris Venture Management Co. V, L.L.C. |
3,769,280 |
24,199,000 |
25.23% |
|
|
| 3 |
WELLINGTON MANAGEMENT GROUP LLP |
1,850,015 |
11,877,000 |
12.38% |
|
|
| 4 |
BVF INC/IL |
1,118,743 |
7,182,000 |
7.49% |
|
|
| 5 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
800,000 |
5,136,000 |
5.36% |
|
|
| 6 |
PERCEPTIVE ADVISORS LLC |
770,000 |
4,943,000 |
5.15% |
|
|
| 7 |
PUTNAM INVESTMENTS LLC |
607,289 |
3,899,000 |
4.07% |
|
|
| 8 |
Broadfin Capital, LLC |
600,000 |
3,852,000 |
4.02% |
|
|
| 9 |
Meiji Yasuda Life Insurance Co |
388,100 |
2,492,000 |
2.60% |
|
|
| 10 |
SPHERA FUNDS MANAGEMENT LTD. |
331,111 |
2,126,000 |
2.22% |
|
|
| 11 |
Alyeska Investment Group, L.P. |
150,266 |
965,000 |
1.01% |
|
|
| 12 |
VANGUARD GROUP INC |
137,584 |
883,000 |
0.92% |
|
|
| 13 |
JPMORGAN CHASE & CO |
131,300 |
842,000 |
0.88% |
|
|
| 14 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
125,000 |
803,000 |
0.84% |
|
|
| 15 |
BLACKROCK ADVISORS LLC |
73,704 |
473,000 |
0.49% |
|
|
| 16 |
BlackRock Institutional Trust Company, N.A. |
52,768 |
339,000 |
0.35% |
|
|
| 17 |
GEODE CAPITAL MANAGEMENT, LLC |
40,834 |
262,000 |
0.27% |
|
|
| 18 |
CITIZENS & NORTHERN CORP |
40,000 |
257,000 |
0.27% |
|
|
| 19 |
DEUTSCHE BANK AG\ |
26,833 |
172,000 |
0.18% |
|
|
| 20 |
BANQUE PICTET & CIE SA |
22,432 |
144,000 |
0.15% |
|
|
| 21 |
HAMILTON LANE ADVISORS LLC |
20,161 |
129,000 |
0.13% |
|
|
| 22 |
BlackRock Group LTD |
18,097 |
116,000 |
0.12% |
|
|
| 23 |
RUSSELL FRANK CO/ |
15,004 |
96,000 |
0.10% |
|
|
| 24 |
NATIONAL PLANNING CORP |
15,475 |
93,000 |
0.10% |
|
|
| 25 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
10,100 |
65,000 |
0.07% |
|
|
| 26 |
BlackRock Fund Advisors |
4,933 |
32,000 |
0.03% |
|
|
| 27 |
MORGAN STANLEY |
3,141 |
20,000 |
0.02% |
|
|
| 28 |
Tower Research Capital LLC (TRC) |
2,017 |
13,000 |
0.01% |
|
|
| 29 |
BARCLAYS PLC |
2,217 |
13,000 |
0.01% |
|
|
| 30 |
BlackRock Investment Management, LLC |
1,305 |
8,000 |
0.01% |
|
|
| 31 |
BANK OF AMERICA CORP /DE/ |
500 |
3,000 |
0.00% |
|
|
| 32 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
100 |
1,000 |
0.00% |
|
|
| 33 |
BNP PARIBAS FINANCIAL MARKETS |
26 |
167 |
0.00% |
|
|
| 34 |
CITIGROUP INC |
49 |
0 |
0.00% |
|
|
