| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BlackRock Finance, Inc. | 4,467,718 | 72,824,000 | 11.46% | ||
| 2 | Palo Alto Investors LP | 4,203,270 | 68,513,000 | 10.78% | ||
| 3 | VANGUARD GROUP INC | 2,680,895 | 43,698,000 | 6.88% | ||
| 4 | GREAT POINT PARTNERS LLC | 2,232,238 | 36,385,000 | 5.73% | ||
| 5 | ARMISTICE CAPITAL, LLC | 2,064,000 | 33,643,000 | 5.29% | ||
| 6 | Point72 Asset Management, L.P. | 1,942,400 | 31,661,000 | 4.98% | ||
| 7 | MACQUARIE GROUP LTD | 1,703,559 | 27,768,000 | 4.37% | ||
| 8 | STATE STREET CORP | 1,618,485 | 26,380,000 | 4.15% | ||
| 9 | FMR LLC | 1,601,171 | 26,099,000 | 4.11% | ||
| 10 | MORGAN STANLEY | 1,184,333 | 19,305,000 | 3.04% | ||
| 11 | RENAISSANCE TECHNOLOGIES LLC | 1,097,950 | 17,897,000 | 2.82% | ||
| 12 | ORBIMED ADVISORS LLC | 967,859 | 15,776,000 | 2.48% | ||
| 13 | Avoro Capital Advisors LLC | 902,146 | 14,705,000 | 2.31% | ||
| 14 | STONEPINE CAPITAL MANAGEMENT, LLC | 685,086 | 11,167,000 | 1.76% | ||
| 15 | TEACHERS ADVISORS, LLC | 610,338 | 9,949,000 | 1.57% | ||
| 16 | NORTHERN TRUST CORP | 597,928 | 9,747,000 | 1.53% | ||
| 17 | PRUDENTIAL FINANCIAL INC | 581,488 | 9,478,000 | 1.49% | ||
| 18 | AJO, LP | 541,927 | 8,833,000 | 1.39% | ||
| 19 | CITADEL ADVISORS LLC | 498,518 | 8,126,000 | 1.28% | ||
| 20 | NEXTHERA CAPITAL LP | 462,200 | 7,534,000 | 1.19% | ||
| 21 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 460,869 | 7,513,000 | 1.18% | ||
| 22 | MILLENNIUM MANAGEMENT LLC | 434,479 | 7,082,000 | 1.11% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 432,054 | 7,042,000 | 1.11% | ||
| 24 | QS Investors, LLC | 346,359 | 5,646,000 | 0.89% | ||
| 25 | GOLDMAN SACHS GROUP INC | 321,090 | 5,233,000 | 0.82% | ||
| 26 | PNC FINANCIAL SERVICES GROUP, INC. | 318,788 | 5,196,000 | 0.82% | ||
| 27 | TIAA CREF INVESTMENT MANAGEMENT LLC | 309,682 | 5,048,000 | 0.79% | ||
| 28 | Spark Investment Management LLC | 293,400 | 4,782,000 | 0.75% | ||
| 29 | DEUTSCHE BANK AG\ | 290,230 | 4,729,000 | 0.74% | ||
| 30 | Numeric Investors LLC | 228,900 | 3,731,000 | 0.59% | ||
| 31 | OXFORD ASSET MANAGEMENT LLP | 224,281 | 3,656,000 | 0.58% | ||
| 32 | PRINCIPAL FINANCIAL GROUP INC | 212,398 | 3,462,000 | 0.54% | ||
| 33 | D. E. Shaw & Co., Inc. | 210,649 | 3,434,000 | 0.54% | ||
| 34 | Bank of New York Mellon Corp | 196,273 | 3,199,000 | 0.50% | ||
| 35 | TWO SIGMA INVESTMENTS, LP | 190,582 | 3,106,000 | 0.49% | ||
| 36 | Gotham Asset Management, LLC | 173,923 | 2,835,000 | 0.45% | ||
| 37 | Candriam S.C.A. | 170,000 | 2,771,000 | 0.44% | ||
| 38 | TWO SIGMA ADVISERS, LP | 147,100 | 2,398,000 | 0.38% | ||
| 39 | JPMORGAN CHASE & CO | 140,173 | 2,285,000 | 0.36% | ||
| 40 | Allianz Asset Management GmbH | 134,937 | 2,199,000 | 0.35% | ||
| 41 | AXIOM INVESTORS LLC /DE | 134,653 | 2,195,000 | 0.35% | ||
| 42 | SECOR Capital Advisors, LP | 121,138 | 1,975,000 | 0.31% | ||
| 43 | BANK OF AMERICA CORP /DE/ | 118,250 | 1,927,000 | 0.30% | ||
| 44 | PDT Partners, LLC | 98,360 | 1,603,000 | 0.25% | ||
| 45 | RUSSELL INVESTMENTS GROUP, LTD. | 93,995 | 1,532,000 | 0.24% | ||
| 46 | PANAGORA ASSET MANAGEMENT INC | 93,110 | 1,518,000 | 0.24% | ||
| 47 | AMERIPRISE FINANCIAL INC | 88,436 | 1,441,000 | 0.23% | ||
| 48 | BANK OF MONTREAL /CAN/ | 81,247 | 1,324,000 | 0.21% | ||
| 49 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 78,040 | 1,272,000 | 0.20% | ||
| 50 | VIRTUS ETF ADVISERS LLC | 74,733 | 1,218,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
