| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | VANGUARD GROUP INC | 3,618,843 | 338,831,000 | 6.85% | ||
| 2 | BlackRock Finance, Inc. | 3,396,752 | 318,039,000 | 6.43% | ||
| 3 | Palo Alto Investors LP | 3,329,581 | 311,749,000 | 6.30% | ||
| 4 | ORBIMED ADVISORS LLC | 2,104,370 | 197,032,000 | 3.98% | ||
| 5 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,033,263 | 190,374,000 | 3.85% | ||
| 6 | PointState Capital LP | 1,995,139 | 186,805,000 | 3.77% | ||
| 7 | STATE STREET CORP | 1,943,480 | 181,966,000 | 3.68% | ||
| 8 | FMR LLC | 1,732,981 | 162,259,000 | 3.28% | ||
| 9 | FRANKLIN RESOURCES INC | 1,665,200 | 155,913,000 | 3.15% | ||
| 10 | JENNISON ASSOCIATES LLC | 1,185,177 | 110,968,000 | 2.24% | ||
| 11 | D. E. Shaw & Co., Inc. | 1,079,731 | 101,095,000 | 2.04% | ||
| 12 | ALLIANCEBERNSTEIN L.P. | 958,721 | 89,765,000 | 1.81% | ||
| 13 | CITADEL ADVISORS LLC | 821,817 | 76,947,000 | 1.55% | ||
| 14 | Redmile Group, LLC | 764,389 | 71,570,000 | 1.45% | ||
| 15 | Bank of New York Mellon Corp | 733,846 | 68,709,000 | 1.39% | ||
| 16 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 666,300 | 62,386,000 | 1.26% | Call | |
| 17 | BANK OF AMERICA CORP /DE/ | 647,175 | 60,595,000 | 1.22% | ||
| 18 | EAGLE ASSET MANAGEMENT INC | 621,111 | 58,154,000 | 1.18% | ||
| 19 | FARALLON CAPITAL MANAGEMENT LLC | 610,000 | 57,114,000 | 1.15% | ||
| 20 | LORD, ABBETT & CO. LLC | 579,397 | 54,249,000 | 1.10% | ||
| 21 | PUTNAM INVESTMENTS LLC | 579,243 | 54,235,000 | 1.10% | ||
| 22 | SAMLYN CAPITAL, LLC | 567,700 | 53,154,000 | 1.07% | ||
| 23 | FRED ALGER MANAGEMENT, LLC | 557,680 | 52,216,000 | 1.06% | ||
| 24 | Consonance Capital Management LP | 544,843 | 51,014,000 | 1.03% | ||
| 25 | NORTHERN TRUST CORP | 527,608 | 49,398,000 | 1.00% | ||
| 26 | NORGES BANK | 505,482 | 47,328,000 | 0.96% | ||
| 27 | BOXER CAPITAL, LLC | 500,000 | 46,815,000 | 0.95% | ||
| 28 | TEACHERS ADVISORS, LLC | 469,572 | 43,966,000 | 0.89% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 459,800 | 43,051,000 | 0.87% | Put | |
| 30 | BALYASNY ASSET MANAGEMENT L.P. | 446,251 | 41,782,000 | 0.84% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 426,247 | 39,909,000 | 0.81% | ||
| 32 | AMERIPRISE FINANCIAL INC | 418,764 | 39,211,000 | 0.79% | ||
| 33 | Invesco Ltd. | 411,024 | 38,484,000 | 0.78% | ||
| 34 | GOLDMAN SACHS GROUP INC | 381,664 | 35,736,000 | 0.72% | ||
| 35 | PFM Health Sciences, LP | 370,141 | 34,656,000 | 0.70% | ||
| 36 | TWO SIGMA INVESTMENTS, LP | 362,919 | 33,980,000 | 0.69% | ||
| 37 | HealthCor Management, L.P. | 350,000 | 32,771,000 | 0.66% | Call | |
| 38 | MACQUARIE GROUP LTD | 337,669 | 31,616,000 | 0.64% | ||
| 39 | RENAISSANCE TECHNOLOGIES LLC | 326,200 | 30,542,000 | 0.62% | ||
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 319,378 | 29,903,000 | 0.60% | ||
| 41 | BARCLAYS PLC | 315,900 | 29,577,000 | 0.60% | Call | |
| 42 | WESTFIELD CAPITAL MANAGEMENT CO LP | 315,170 | 29,509,000 | 0.60% | ||
| 43 | DEUTSCHE BANK AG\ | 302,233 | 28,296,000 | 0.57% | ||
| 44 | Ghost Tree Capital, LLC | 301,000 | 28,183,000 | 0.57% | Call | |
| 45 | CITIGROUP INC | 287,543 | 26,922,000 | 0.54% | ||
| 46 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 284,481 | 26,635,955 | 0.54% | ||
| 47 | EMERALD ADVISERS, LLC | 254,024 | 23,784,000 | 0.48% | ||
| 48 | HealthCor Management, L.P. | 246,300 | 23,061,000 | 0.47% | ||
| 49 | VOLORIDGE INVESTMENT MANAGEMENT, LLC | 237,631 | 22,249,000 | 0.45% | ||
| 50 | WELLS FARGO & COMPANY/MN | 232,270 | 21,748,000 | 0.44% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
