| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 5,215,128 | 131,578,000 | 17.89% | ||
| 2 | FMR LLC | 4,778,253 | 120,556,000 | 16.39% | ||
| 3 | BAKER BROS. ADVISORS LP | 4,582,382 | 115,613,000 | 15.72% | ||
| 4 | Versant Venture Management, LLC | 1,281,152 | 32,323,465 | 4.40% | ||
| 5 | Polar Capital LLP | 1,280,971 | 32,319,000 | 4.39% | ||
| 6 | FORESITE CAPITAL MANAGEMENT III, LLC | 1,245,187 | 31,416,000 | 4.27% | ||
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,092,777 | 27,571,000 | 3.75% | ||
| 8 | VANGUARD GROUP INC | 1,066,701 | 26,913,000 | 3.66% | ||
| 9 | FARALLON CAPITAL MANAGEMENT LLC | 817,500 | 20,626,000 | 2.80% | ||
| 10 | Point72 Asset Management, L.P. | 570,971 | 14,406,000 | 1.96% | ||
| 11 | TimesSquare Capital Management, LLC | 526,600 | 13,286,000 | 1.81% | ||
| 12 | BlackRock Finance, Inc. | 495,516 | 12,502,000 | 1.70% | ||
| 13 | STATE STREET CORP | 416,588 | 10,510,000 | 1.43% | ||
| 14 | SCHONFELD STRATEGIC ADVISORS LLC | 414,370 | 10,455,000 | 1.42% | ||
| 15 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 292,200 | 7,372,000 | 1.00% | Call | |
| 16 | CITADEL ADVISORS LLC | 282,401 | 7,125,000 | 0.97% | ||
| 17 | INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 280,038 | 7,065,000 | 0.96% | ||
| 18 | Informed Momentum Co LLC | 277,567 | 7,003,000 | 0.95% | ||
| 19 | Fiera Capital Corp | 275,771 | 6,958,000 | 0.95% | ||
| 20 | AXA S.A. | 263,041 | 6,637,000 | 0.90% | ||
| 21 | Nicholas Investment Partners, LP | 248,168 | 6,261,000 | 0.85% | ||
| 22 | MILLENNIUM MANAGEMENT LLC | 223,051 | 5,628,000 | 0.77% | ||
| 23 | Spark Investment Management LLC | 212,100 | 5,351,000 | 0.73% | ||
| 24 | SPHERA FUNDS MANAGEMENT LTD. | 200,000 | 5,046,000 | 0.69% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 191,200 | 4,824,000 | 0.66% | Put | |
| 26 | LORD, ABBETT & CO. LLC | 172,154 | 4,343,000 | 0.59% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 166,055 | 4,189,000 | 0.57% | ||
| 28 | BANK OF AMERICA CORP /DE/ | 138,626 | 3,497,000 | 0.48% | ||
| 29 | AWM Investment Company, Inc. | 130,000 | 3,280,000 | 0.45% | ||
| 30 | GOLDMAN SACHS GROUP INC | 121,439 | 3,064,000 | 0.42% | ||
| 31 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 120,785 | 3,047,000 | 0.41% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 116,723 | 2,945,000 | 0.40% | ||
| 33 | Bank of New York Mellon Corp | 113,783 | 2,871,000 | 0.39% | ||
| 34 | Raymond James Financial Services Advisors, Inc. | 104,850 | 2,645,000 | 0.36% | ||
| 35 | Laurion Capital Management LP | 100,199 | 2,528,000 | 0.34% | ||
| 36 | DEUTSCHE BANK AG\ | 94,183 | 2,376,000 | 0.32% | ||
| 37 | Candriam S.C.A. | 80,555 | 2,032,000 | 0.28% | ||
| 38 | AMERIPRISE FINANCIAL INC | 78,960 | 1,998,000 | 0.27% | ||
| 39 | GABELLI FUNDS LLC | 61,800 | 1,559,000 | 0.21% | ||
| 40 | Artal Group S.A. | 60,000 | 1,514,000 | 0.21% | ||
| 41 | Iguana Healthcare Management, LLC | 60,000 | 1,514,000 | 0.21% | ||
| 42 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 51,359 | 1,296,000 | 0.18% | ||
| 43 | TD ASSET MANAGEMENT INC | 48,226 | 1,217,000 | 0.17% | ||
| 44 | NORTHERN TRUST CORP | 47,447 | 1,197,000 | 0.16% | ||
| 45 | UBS Group AG | 45,488 | 1,148,000 | 0.16% | ||
| 46 | SG Americas Securities, LLC | 44,161 | 1,114,000 | 0.15% | ||
| 47 | MORGAN STANLEY | 43,698 | 1,103,000 | 0.15% | ||
| 48 | Segantii Capital Management Ltd | 41,625 | 1,050,000 | 0.14% | ||
| 49 | TUDOR INVESTMENT CORP ET AL | 36,450 | 920,000 | 0.13% | ||
| 50 | GRATICULE ASIA MACRO ADVISORS LLC | 34,800 | 878,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
