| # | % | |||||
|---|---|---|---|---|---|---|
| 51 | Artal Group S.A. | 60,000 | 1,514,000 | 0.21% | ||
| 52 | GABELLI FUNDS LLC | 61,800 | 1,559,000 | 0.21% | ||
| 53 | AMERIPRISE FINANCIAL INC | 78,960 | 1,998,000 | 0.27% | ||
| 54 | Candriam S.C.A. | 80,555 | 2,032,000 | 0.28% | ||
| 55 | DEUTSCHE BANK AG\ | 94,183 | 2,376,000 | 0.32% | ||
| 56 | Laurion Capital Management LP | 100,199 | 2,528,000 | 0.34% | ||
| 57 | Raymond James Financial Services Advisors, Inc. | 104,850 | 2,645,000 | 0.36% | ||
| 58 | Bank of New York Mellon Corp | 113,783 | 2,871,000 | 0.39% | ||
| 59 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 116,723 | 2,945,000 | 0.40% | ||
| 60 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 120,785 | 3,047,000 | 0.41% | ||
| 61 | GOLDMAN SACHS GROUP INC | 121,439 | 3,064,000 | 0.42% | ||
| 62 | AWM Investment Company, Inc. | 130,000 | 3,280,000 | 0.45% | ||
| 63 | BANK OF AMERICA CORP /DE/ | 138,626 | 3,497,000 | 0.48% | ||
| 64 | GEODE CAPITAL MANAGEMENT, LLC | 166,055 | 4,189,000 | 0.57% | ||
| 65 | LORD, ABBETT & CO. LLC | 172,154 | 4,343,000 | 0.59% | ||
| 66 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 191,200 | 4,824,000 | 0.66% | Put | |
| 67 | SPHERA FUNDS MANAGEMENT LTD. | 200,000 | 5,046,000 | 0.69% | ||
| 68 | Spark Investment Management LLC | 212,100 | 5,351,000 | 0.73% | ||
| 69 | MILLENNIUM MANAGEMENT LLC | 223,051 | 5,628,000 | 0.77% | ||
| 70 | Nicholas Investment Partners, LP | 248,168 | 6,261,000 | 0.85% | ||
| 71 | AXA S.A. | 263,041 | 6,637,000 | 0.90% | ||
| 72 | Fiera Capital Corp | 275,771 | 6,958,000 | 0.95% | ||
| 73 | Informed Momentum Co LLC | 277,567 | 7,003,000 | 0.95% | ||
| 74 | INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 280,038 | 7,065,000 | 0.96% | ||
| 75 | CITADEL ADVISORS LLC | 282,401 | 7,125,000 | 0.97% | ||
| 76 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 292,200 | 7,372,000 | 1.00% | Call | |
| 77 | SCHONFELD STRATEGIC ADVISORS LLC | 414,370 | 10,455,000 | 1.42% | ||
| 78 | STATE STREET CORP | 416,588 | 10,510,000 | 1.43% | ||
| 79 | BlackRock Finance, Inc. | 495,516 | 12,502,000 | 1.70% | ||
| 80 | TimesSquare Capital Management, LLC | 526,600 | 13,286,000 | 1.81% | ||
| 81 | Point72 Asset Management, L.P. | 570,971 | 14,406,000 | 1.96% | ||
| 82 | FARALLON CAPITAL MANAGEMENT LLC | 817,500 | 20,626,000 | 2.80% | ||
| 83 | VANGUARD GROUP INC | 1,066,701 | 26,913,000 | 3.66% | ||
| 84 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,092,777 | 27,571,000 | 3.75% | ||
| 85 | FORESITE CAPITAL MANAGEMENT III, LLC | 1,245,187 | 31,416,000 | 4.27% | ||
| 86 | Polar Capital LLP | 1,280,971 | 32,319,000 | 4.39% | ||
| 87 | Versant Venture Management, LLC | 1,281,152 | 32,323,465 | 4.40% | ||
| 88 | BAKER BROS. ADVISORS LP | 4,582,382 | 115,613,000 | 15.72% | ||
| 89 | FMR LLC | 4,778,253 | 120,556,000 | 16.39% | ||
| 90 | NEA Management Company, LLC | 5,215,128 | 131,578,000 | 17.89% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
