| 1 |
Essex Woodlands Management, Inc. |
4,592,047 |
144,649,000 |
38.81% |
|
|
| 2 |
Visium Asset Management, LP |
898,000 |
28,287,000 |
7.59% |
|
|
| 3 |
WADDELL & REED FINANCIAL INC |
529,757 |
16,688,000 |
4.48% |
|
|
| 4 |
COLUMBIA WANGER ASSET MANAGEMENT LLC |
519,147 |
16,353,000 |
4.39% |
|
|
| 5 |
MILLENNIUM MANAGEMENT LLC |
321,082 |
10,114,000 |
2.71% |
|
|
| 6 |
PFM Health Sciences, LP |
320,903 |
10,108,000 |
2.71% |
|
|
| 7 |
RS INVESTMENT MANAGEMENT CO LLC |
316,000 |
9,954,000 |
2.67% |
|
|
| 8 |
FMR LLC |
303,300 |
9,554,000 |
2.56% |
|
|
| 9 |
Camber Capital Management LP |
300,000 |
9,450,000 |
2.54% |
|
|
| 10 |
Zweig-DiMenna Associates LLC |
289,606 |
9,123,000 |
2.45% |
|
|
| 11 |
JPMORGAN CHASE & CO |
269,200 |
8,480,000 |
2.28% |
|
|
| 12 |
DRIEHAUS CAPITAL MANAGEMENT LLC |
268,518 |
8,458,000 |
2.27% |
|
|
| 13 |
Polar Capital LLP |
247,453 |
7,795,000 |
2.09% |
|
|
| 14 |
GOLDMAN SACHS GROUP INC |
243,103 |
7,658,000 |
2.05% |
|
|
| 15 |
BlackRock Fund Advisors |
189,747 |
5,977,000 |
1.60% |
|
|
| 16 |
JENNISON ASSOCIATES LLC |
174,972 |
5,512,000 |
1.48% |
|
|
| 17 |
AMERIPRISE FINANCIAL INC |
164,466 |
5,180,000 |
1.39% |
|
|
| 18 |
BlackRock Institutional Trust Company, N.A. |
151,593 |
4,775,000 |
1.28% |
|
|
| 19 |
VANGUARD GROUP INC |
134,888 |
4,249,000 |
1.14% |
|
|
| 20 |
LORD, ABBETT & CO. LLC |
123,900 |
3,903,000 |
1.05% |
|
|
| 21 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
116,689 |
3,676,000 |
0.99% |
|
|
| 22 |
Zurcher Kantonalbank (Zurich Cantonalbank) |
100,000 |
3,150,000 |
0.85% |
|
|
| 23 |
Lombard Odier Asset Management (USA) Corp |
100,000 |
3,150,000 |
0.85% |
|
|
| 24 |
WALL STREET ASSOCIATES |
91,710 |
2,889,000 |
0.78% |
|
|
| 25 |
Palo Alto Investors LP |
91,669 |
2,888,000 |
0.77% |
|
|
| 26 |
CITADEL ADVISORS LLC |
80,600 |
2,539,000 |
0.68% |
|
|
| 27 |
STATE STREET CORP |
65,495 |
2,063,000 |
0.55% |
|
|
| 28 |
MORGAN STANLEY |
62,820 |
1,979,000 |
0.53% |
|
|
| 29 |
PRINCIPAL FINANCIAL GROUP INC |
60,000 |
1,890,000 |
0.51% |
|
|
| 30 |
BLACKROCK ADVISORS LLC |
49,666 |
1,564,000 |
0.42% |
|
|
| 31 |
FEDERATED HERMES, INC. |
49,490 |
1,559,000 |
0.42% |
|
|
| 32 |
Rhenman & Partners Asset Management AB |
49,135 |
1,548,000 |
0.42% |
|
|
| 33 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
48,300 |
1,521,000 |
0.41% |
|
|
| 34 |
LEVIN CAPITAL STRATEGIES, L.P. |
46,954 |
1,479,000 |
0.40% |
|
|
| 35 |
TCW GROUP INC |
44,082 |
1,389,000 |
0.37% |
|
|
| 36 |
PANAGORA ASSET MANAGEMENT INC |
38,573 |
1,215,000 |
0.33% |
|
|
| 37 |
GEODE CAPITAL MANAGEMENT, LLC |
35,143 |
1,106,000 |
0.30% |
|
|
| 38 |
NORTHERN TRUST CORP |
28,591 |
901,000 |
0.24% |
|
|
| 39 |
State of New Jersey Common Pension Fund A |
26,000 |
819,000 |
0.22% |
|
|
| 40 |
Standard Investments LLC |
25,300 |
797,000 |
0.21% |
|
|
| 41 |
Geduld E E |
25,000 |
788,000 |
0.21% |
|
|
| 42 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
22,078 |
695,000 |
0.19% |
|
|
| 43 |
Granite Point Capital Management, L.P. |
21,600 |
680,000 |
0.18% |
|
|
| 44 |
Ghost Tree Capital, LLC |
20,000 |
630,000 |
0.17% |
|
|
| 45 |
ArrowMark Colorado Holdings LLC |
19,527 |
615,000 |
0.16% |
|
|
| 46 |
BlackRock Investment Management, LLC |
19,200 |
605,000 |
0.16% |
|
|
| 47 |
Bank of New York Mellon Corp |
18,294 |
576,000 |
0.15% |
|
|
| 48 |
BAMCO INC /NY/ |
17,500 |
551,000 |
0.15% |
|
|
| 49 |
Nationwide Fund Advisors |
15,118 |
476,000 |
0.13% |
|
|
| 50 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
12,600 |
397,000 |
0.11% |
|
|
