| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Essex Woodlands Management, Inc. | 4,592,047 | 156,130,000 | 28.07% | ||
| 2 | JENNISON ASSOCIATES LLC | 1,121,134 | 38,119,000 | 6.85% | ||
| 3 | FMR LLC | 1,003,700 | 34,126,000 | 6.14% | ||
| 4 | JPMORGAN CHASE & CO | 675,598 | 22,969,000 | 4.13% | ||
| 5 | Camber Capital Management LP | 630,000 | 21,420,000 | 3.85% | ||
| 6 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 589,000 | 20,026,000 | 3.60% | ||
| 7 | Polar Capital LLP | 577,042 | 19,618,000 | 3.53% | ||
| 8 | GOLDMAN SACHS GROUP INC | 439,702 | 14,950,000 | 2.69% | ||
| 9 | ArrowMark Colorado Holdings LLC | 433,457 | 14,738,000 | 2.65% | ||
| 10 | WADDELL & REED FINANCIAL INC | 380,676 | 12,943,000 | 2.33% | ||
| 11 | ALLIANCEBERNSTEIN L.P. | 373,921 | 12,713,000 | 2.29% | ||
| 12 | Visium Asset Management, LP | 362,922 | 12,339,000 | 2.22% | ||
| 13 | RS INVESTMENT MANAGEMENT CO LLC | 349,566 | 11,885,000 | 2.14% | ||
| 14 | FRANKLIN RESOURCES INC | 346,663 | 11,787,000 | 2.12% | ||
| 15 | DRIEHAUS CAPITAL MANAGEMENT LLC | 267,054 | 9,080,000 | 1.63% | ||
| 16 | DEERFIELD MANAGEMENT COMPANY, L.P. | 256,500 | 8,721,000 | 1.57% | ||
| 17 | PFM Health Sciences, LP | 235,862 | 8,019,000 | 1.44% | ||
| 18 | VANGUARD GROUP INC | 228,026 | 7,753,000 | 1.39% | ||
| 19 | LORD, ABBETT & CO. LLC | 200,683 | 6,823,000 | 1.23% | ||
| 20 | LEVIN CAPITAL STRATEGIES, L.P. | 184,766 | 6,282,000 | 1.13% | ||
| 21 | AMERIPRISE FINANCIAL INC | 184,221 | 6,264,000 | 1.13% | ||
| 22 | BlackRock Fund Advisors | 176,314 | 5,995,000 | 1.08% | ||
| 23 | Lombard Odier Asset Management (USA) Corp | 150,000 | 5,100,000 | 0.92% | ||
| 24 | Zurcher Kantonalbank (Zurich Cantonalbank) | 130,000 | 4,420,000 | 0.79% | ||
| 25 | CITADEL ADVISORS LLC | 125,289 | 4,260,000 | 0.77% | ||
| 26 | BlackRock Institutional Trust Company, N.A. | 120,700 | 4,104,000 | 0.74% | ||
| 27 | MILLENNIUM MANAGEMENT LLC | 120,473 | 4,096,000 | 0.74% | ||
| 28 | Bank of New York Mellon Corp | 109,427 | 3,722,000 | 0.67% | ||
| 29 | Pier Capital, LLC | 106,985 | 3,637,000 | 0.65% | ||
| 30 | MOORE CAPITAL MANAGEMENT, LP | 100,000 | 3,400,000 | 0.61% | ||
| 31 | Palo Alto Investors LP | 91,669 | 3,117,000 | 0.56% | ||
| 32 | STATE STREET CORP | 91,229 | 3,103,000 | 0.56% | ||
| 33 | Zweig-DiMenna Associates LLC | 84,960 | 2,889,000 | 0.52% | ||
| 34 | WALL STREET ASSOCIATES | 82,010 | 2,788,000 | 0.50% | ||
| 35 | Rhenman & Partners Asset Management AB | 82,000 | 2,788,000 | 0.50% | ||
| 36 | NORTHERN TRUST CORP | 74,564 | 2,535,000 | 0.46% | ||
| 37 | HIGHLAND CAPITAL MANAGEMENT LP | 72,866 | 2,477,000 | 0.45% | ||
| 38 | SABBY MANAGEMENT, LLC | 67,200 | 2,285,000 | 0.41% | ||
| 39 | PRINCIPAL FINANCIAL GROUP INC | 67,035 | 2,279,000 | 0.41% | ||
| 40 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 65,200 | 2,217,000 | 0.40% | ||
| 41 | Nicholas Investment Partners, LP | 60,255 | 2,049,000 | 0.37% | ||
| 42 | Alyeska Investment Group, L.P. | 60,000 | 2,040,000 | 0.37% | ||
| 43 | BLACKROCK ADVISORS LLC | 58,582 | 1,992,000 | 0.36% | ||
| 44 | TCW GROUP INC | 58,373 | 1,985,000 | 0.36% | ||
| 45 | Informed Momentum Co LLC | 52,668 | 1,791,000 | 0.32% | ||
| 46 | GREEN ARROW CAPITAL MANAGEMENT LLC | 50,000 | 1,700,000 | 0.31% | ||
| 47 | Granite Point Capital Management, L.P. | 50,000 | 1,700,000 | 0.31% | ||
| 48 | SCHRODER INVESTMENT MANAGEMENT GROUP | 50,000 | 1,700,000 | 0.31% | ||
| 49 | GEODE CAPITAL MANAGEMENT, LLC | 40,949 | 1,392,000 | 0.25% | ||
| 50 | PANAGORA ASSET MANAGEMENT INC | 37,118 | 1,262,000 | 0.23% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
