| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Essex Woodlands Management, Inc. | 4,592,047 | 136,659,000 | 20.70% | ||
| 2 | FRANKLIN RESOURCES INC | 3,244,280 | 96,549,000 | 14.62% | ||
| 3 | NQ HCIF GP, Ltd. | 3,096,650 | 92,156,000 | 13.96% | ||
| 4 | Bank of New York Mellon Corp | 1,911,487 | 56,887,000 | 8.62% | ||
| 5 | JPMORGAN CHASE & CO | 1,394,779 | 41,509,000 | 6.29% | ||
| 6 | Polar Capital LLP | 1,184,530 | 35,246,000 | 5.34% | ||
| 7 | BlackRock Fund Advisors | 752,964 | 22,408,000 | 3.39% | ||
| 8 | CANADA PENSION PLAN INVESTMENT BOARD | 610,300 | 18,163,000 | 2.75% | ||
| 9 | ArrowMark Colorado Holdings LLC | 588,071 | 17,501,000 | 2.65% | ||
| 10 | VANGUARD GROUP INC | 482,612 | 14,363,000 | 2.18% | ||
| 11 | GOLDMAN SACHS GROUP INC | 381,485 | 11,353,000 | 1.72% | ||
| 12 | WADDELL & REED FINANCIAL INC | 376,150 | 11,194,000 | 1.70% | ||
| 13 | ALPS ADVISORS INC | 37,481 | 11,154,000 | 1.69% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 291,800 | 8,684,000 | 1.32% | ||
| 15 | STATE STREET CORP | 226,106 | 6,733,000 | 1.02% | ||
| 16 | Lombard Odier Asset Management (USA) Corp | 225,000 | 6,696,000 | 1.01% | ||
| 17 | LORD, ABBETT & CO. LLC | 199,544 | 5,938,000 | 0.90% | ||
| 18 | NORTHERN TRUST CORP | 177,308 | 5,277,000 | 0.80% | ||
| 19 | MILLENNIUM MANAGEMENT LLC | 176,801 | 5,262,000 | 0.80% | ||
| 20 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 175,773 | 5,231,000 | 0.79% | ||
| 21 | Rhenman & Partners Asset Management AB | 148,000 | 4,404,000 | 0.67% | ||
| 22 | BALYASNY ASSET MANAGEMENT L.P. | 100,000 | 2,976,000 | 0.45% | Call | |
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 96,903 | 2,883,000 | 0.44% | ||
| 24 | WELLINGTON MANAGEMENT GROUP LLP | 89,242 | 2,656,000 | 0.40% | ||
| 25 | RENAISSANCE TECHNOLOGIES LLC | 87,500 | 2,604,000 | 0.39% | ||
| 26 | PRINCIPAL FINANCIAL GROUP INC | 78,267 | 2,329,000 | 0.35% | ||
| 27 | JENNISON ASSOCIATES LLC | 78,156 | 2,326,000 | 0.35% | ||
| 28 | ESSEX INVESTMENT MANAGEMENT CO LLC | 71,701 | 2,134,000 | 0.32% | ||
| 29 | BAIRD FINANCIAL GROUP, INC. | 69,496 | 2,068,000 | 0.31% | ||
| 30 | BlackRock Investment Management, LLC | 55,292 | 1,645,000 | 0.25% | ||
| 31 | TIAA CREF INVESTMENT MANAGEMENT LLC | 52,528 | 1,563,000 | 0.24% | ||
| 32 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 46,842 | 1,395,000 | 0.21% | ||
| 33 | FIL Ltd | 44,064 | 1,311,000 | 0.20% | ||
| 34 | LEVIN CAPITAL STRATEGIES, L.P. | 43,844 | 1,305,000 | 0.20% | ||
| 35 | Trexquant Investment LP | 40,300 | 1,199,000 | 0.18% | ||
| 36 | Iguana Healthcare Management, LLC | 35,000 | 1,042,000 | 0.16% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 34,589 | 1,029,000 | 0.16% | ||
| 38 | BARCLAYS PLC | 35,022 | 1,016,000 | 0.15% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 33,800 | 1,006,000 | 0.15% | Put | |
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 33,600 | 1,000,000 | 0.15% | Call | |
| 41 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 28,474 | 847,000 | 0.13% | ||
| 42 | State of New Jersey Common Pension Fund D | 26,000 | 774,000 | 0.12% | ||
| 43 | COLUMBUS CIRCLE INVESTORS | 25,561 | 761,000 | 0.12% | ||
| 44 | D. E. Shaw & Co., Inc. | 25,400 | 756,000 | 0.11% | ||
| 45 | DEUTSCHE BANK AG\ | 23,316 | 692,000 | 0.10% | ||
| 46 | TEACHERS ADVISORS, LLC | 22,897 | 681,000 | 0.10% | ||
| 47 | ALLIANCEBERNSTEIN L.P. | 22,200 | 661,000 | 0.10% | ||
| 48 | BLAIR WILLIAM & CO/IL | 22,007 | 654,000 | 0.10% | ||
| 49 | Swiss National Bank | 20,850 | 620,000 | 0.09% | ||
| 50 | ProShare Advisors LLC | 19,762 | 588,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
