| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Essex Woodlands Management, Inc. | 4,592,047 | 95,055,000 | 17.58% | ||
| 2 | JPMORGAN CHASE & CO | 3,430,158 | 71,004,000 | 13.13% | ||
| 3 | FRANKLIN RESOURCES INC | 3,280,584 | 67,908,000 | 12.56% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 2,149,678 | 44,499,000 | 8.23% | ||
| 5 | ArrowMark Colorado Holdings LLC | 2,018,729 | 41,788,000 | 7.73% | ||
| 6 | Bank of New York Mellon Corp | 1,941,730 | 40,194,000 | 7.44% | ||
| 7 | BlackRock Fund Advisors | 1,398,009 | 28,939,000 | 5.35% | ||
| 8 | Polar Capital LLP | 1,296,371 | 26,826,000 | 4.96% | ||
| 9 | VANGUARD GROUP INC | 825,652 | 17,091,000 | 3.16% | ||
| 10 | CANADA PENSION PLAN INVESTMENT BOARD | 582,900 | 12,066,000 | 2.23% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 516,855 | 10,699,000 | 1.98% | ||
| 12 | GOLDMAN SACHS GROUP INC | 407,250 | 8,430,000 | 1.56% | ||
| 13 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 350,000 | 7,245,000 | 1.34% | ||
| 14 | STATE STREET CORP | 325,148 | 6,729,000 | 1.24% | ||
| 15 | NORTHERN TRUST CORP | 260,314 | 5,389,000 | 1.00% | ||
| 16 | WADDELL & REED FINANCIAL INC | 250,000 | 5,175,000 | 0.96% | ||
| 17 | Rhenman & Partners Asset Management AB | 210,000 | 4,347,000 | 0.80% | ||
| 18 | MORGAN STANLEY | 181,296 | 3,753,000 | 0.69% | ||
| 19 | PointState Capital LP | 175,000 | 3,623,000 | 0.67% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 153,360 | 3,174,000 | 0.59% | ||
| 21 | FMR LLC | 100,000 | 2,070,000 | 0.38% | ||
| 22 | ESSEX INVESTMENT MANAGEMENT CO LLC | 91,228 | 1,888,000 | 0.35% | ||
| 23 | SUFFOLK CAPITAL MANAGEMENT LLC | 91,194 | 1,888,000 | 0.35% | ||
| 24 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 88,557 | 1,834,000 | 0.34% | ||
| 25 | WELLS FARGO & COMPANY/MN | 85,780 | 1,776,000 | 0.33% | ||
| 26 | PRINCIPAL FINANCIAL GROUP INC | 81,213 | 1,681,000 | 0.31% | ||
| 27 | BlackRock Investment Management, LLC | 78,719 | 1,629,000 | 0.30% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 77,687 | 1,608,000 | 0.30% | ||
| 29 | VIVO CAPITAL, LLC | 77,373 | 1,602,000 | 0.30% | ||
| 30 | Granite Investment Partners, LLC | 74,217 | 1,537,000 | 0.28% | ||
| 31 | COLUMBIA PARTNERS L.L.C. INVESTMENT MANAGEMENT | 73,187 | 1,514,000 | 0.28% | ||
| 32 | Candriam S.C.A. | 67,000 | 1,387,000 | 0.26% | ||
| 33 | ROTHSCHILD & CO ASSET MANAGEMENT US INC. | 60,786 | 1,258,000 | 0.23% | ||
| 34 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 57,171 | 1,183,000 | 0.22% | ||
| 35 | MILLENNIUM MANAGEMENT LLC | 50,502 | 1,045,000 | 0.19% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 42,070 | 871,000 | 0.16% | ||
| 37 | TEACHERS ADVISORS, LLC | 33,722 | 698,000 | 0.13% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 31,714 | 656,000 | 0.12% | ||
| 39 | Swiss National Bank | 30,750 | 637,000 | 0.12% | ||
| 40 | Nationwide Fund Advisors | 29,977 | 621,000 | 0.11% | ||
| 41 | ALLIANCEBERNSTEIN L.P. | 27,800 | 575,000 | 0.11% | ||
| 42 | ALPS ADVISORS INC | 27,404 | 567,000 | 0.10% | ||
| 43 | State of New Jersey Common Pension Fund D | 26,000 | 538,000 | 0.10% | ||
| 44 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 25,877 | 536,000 | 0.10% | ||
| 45 | DEUTSCHE BANK AG\ | 23,957 | 494,000 | 0.09% | ||
| 46 | AMERIPRISE FINANCIAL INC | 22,679 | 469,000 | 0.09% | ||
| 47 | ProShare Advisors LLC | 22,124 | 458,000 | 0.08% | ||
| 48 | RHUMBLINE ADVISERS | 20,986 | 434,000 | 0.08% | ||
| 49 | ROYAL BANK OF CANADA | 20,740 | 429,000 | 0.08% | ||
| 50 | FEDERATED HERMES, INC. | 20,000 | 414,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
