| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Essex Woodlands Management, Inc. | 4,592,047 | 80,177,000 | 16.75% | ||
| 2 | FRANKLIN RESOURCES INC | 3,329,070 | 58,126,000 | 12.15% | ||
| 3 | NQ HCIF GP, Ltd. | 3,096,650 | 54,068,000 | 11.30% | ||
| 4 | JPMORGAN CHASE & CO | 3,028,574 | 52,879,000 | 11.05% | ||
| 5 | Bank of New York Mellon Corp | 1,966,175 | 34,329,000 | 7.17% | ||
| 6 | WELLINGTON MANAGEMENT GROUP LLP | 1,651,426 | 28,834,000 | 6.03% | ||
| 7 | Polar Capital LLP | 1,183,631 | 20,665,000 | 4.32% | ||
| 8 | BlackRock Fund Advisors | 1,150,499 | 20,088,000 | 4.20% | ||
| 9 | ArrowMark Colorado Holdings LLC | 1,134,796 | 19,814,000 | 4.14% | ||
| 10 | VANGUARD GROUP INC | 704,340 | 12,297,000 | 2.57% | ||
| 11 | CANADA PENSION PLAN INVESTMENT BOARD | 610,300 | 10,656,000 | 2.23% | ||
| 12 | STATE STREET CORP | 527,316 | 9,206,000 | 1.92% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 492,407 | 8,597,000 | 1.80% | ||
| 14 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 375,000 | 6,548,000 | 1.37% | ||
| 15 | WADDELL & REED FINANCIAL INC | 353,850 | 6,178,000 | 1.29% | ||
| 16 | GOLDMAN SACHS GROUP INC | 300,056 | 5,239,000 | 1.09% | ||
| 17 | NORTHERN TRUST CORP | 214,855 | 3,751,000 | 0.78% | ||
| 18 | Rhenman & Partners Asset Management AB | 170,000 | 2,968,000 | 0.62% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 140,040 | 2,445,000 | 0.51% | ||
| 20 | DRIEHAUS CAPITAL MANAGEMENT LLC | 117,168 | 2,046,000 | 0.43% | ||
| 21 | JHL Capital Group LLC | 110,000 | 1,921,000 | 0.40% | ||
| 22 | VIVO CAPITAL, LLC | 77,373 | 1,886,000 | 0.39% | ||
| 23 | BAIRD FINANCIAL GROUP, INC. | 106,265 | 1,855,000 | 0.39% | ||
| 24 | SUFFOLK CAPITAL MANAGEMENT LLC | 96,471 | 1,684,000 | 0.35% | ||
| 25 | LORD, ABBETT & CO. LLC | 94,700 | 1,653,000 | 0.35% | ||
| 26 | MILLENNIUM MANAGEMENT LLC | 93,115 | 1,626,000 | 0.34% | ||
| 27 | FRED ALGER MANAGEMENT, LLC | 84,288 | 1,472,000 | 0.31% | ||
| 28 | JACOBS LEVY EQUITY MANAGEMENT, INC | 82,890 | 1,447,000 | 0.30% | ||
| 29 | ESSEX INVESTMENT MANAGEMENT CO LLC | 81,701 | 1,426,000 | 0.30% | ||
| 30 | PRINCIPAL FINANCIAL GROUP INC | 81,272 | 1,419,000 | 0.30% | ||
| 31 | UNITED BANK | 77,177 | 1,348,000 | 0.28% | ||
| 32 | MORGAN STANLEY | 75,196 | 1,312,000 | 0.27% | ||
| 33 | Invesco Ltd. | 69,594 | 1,215,000 | 0.25% | ||
| 34 | BlackRock Investment Management, LLC | 65,170 | 1,138,000 | 0.24% | ||
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 64,943 | 1,134,000 | 0.24% | ||
| 36 | COLUMBUS CIRCLE INVESTORS | 63,398 | 1,107,000 | 0.23% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 55,715 | 973,000 | 0.20% | ||
| 38 | D. E. Shaw & Co., Inc. | 54,621 | 954,000 | 0.20% | ||
| 39 | Trexquant Investment LP | 48,002 | 838,000 | 0.18% | ||
| 40 | Tekla Capital Management LLC | 45,000 | 786,000 | 0.16% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 39,781 | 695,000 | 0.15% | ||
| 42 | CREDIT SUISSE AG/ | 39,283 | 685,000 | 0.14% | ||
| 43 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 38,794 | 677,000 | 0.14% | ||
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 38,300 | 669,000 | 0.14% | Put | |
| 45 | NOTTINGHAM ADVISORS, INC. | 18,328 | 626,000 | 0.13% | ||
| 46 | ALPS ADVISORS INC | 31,559 | 551,000 | 0.12% | ||
| 47 | TEACHERS ADVISORS, LLC | 29,750 | 519,000 | 0.11% | ||
| 48 | Swiss National Bank | 30,750 | 518,000 | 0.11% | ||
| 49 | State of New Jersey Common Pension Fund D | 26,000 | 454,000 | 0.09% | ||
| 50 | ALLIANCEBERNSTEIN L.P. | 25,300 | 442,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
