| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Essex Woodlands Management, Inc. | 4,592,047 | 88,764,000 | 29.33% | ||
| 2 | FRANKLIN RESOURCES INC | 1,386,899 | 26,809,000 | 8.86% | ||
| 3 | FMR LLC | 1,029,800 | 19,906,000 | 6.58% | ||
| 4 | JPMORGAN CHASE & CO | 790,817 | 15,287,000 | 5.05% | ||
| 5 | ArrowMark Colorado Holdings LLC | 702,550 | 13,580,000 | 4.49% | ||
| 6 | Polar Capital LLP | 689,780 | 13,332,000 | 4.41% | ||
| 7 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 562,000 | 10,863,000 | 3.59% | ||
| 8 | ALLIANCEBERNSTEIN L.P. | 515,614 | 9,967,000 | 3.29% | ||
| 9 | GOLDMAN SACHS GROUP INC | 425,445 | 8,224,000 | 2.72% | ||
| 10 | RS INVESTMENT MANAGEMENT CO LLC | 421,566 | 8,149,000 | 2.69% | ||
| 11 | PFM Health Sciences, LP | 388,467 | 7,509,000 | 2.48% | ||
| 12 | WADDELL & REED FINANCIAL INC | 376,150 | 7,271,000 | 2.40% | ||
| 13 | VANGUARD GROUP INC | 318,262 | 6,152,000 | 2.03% | ||
| 14 | JENNISON ASSOCIATES LLC | 299,194 | 5,783,000 | 1.91% | ||
| 15 | LORD, ABBETT & CO. LLC | 278,607 | 5,385,000 | 1.78% | ||
| 16 | AMERIPRISE FINANCIAL INC | 234,492 | 4,533,000 | 1.50% | ||
| 17 | BlackRock Fund Advisors | 201,636 | 3,898,000 | 1.29% | ||
| 18 | Lombard Odier Asset Management (USA) Corp | 199,895 | 3,864,000 | 1.28% | ||
| 19 | MILLENNIUM MANAGEMENT LLC | 153,984 | 2,977,000 | 0.98% | ||
| 20 | Adamant Biomedical Investments AG | 130,000 | 2,513,000 | 0.83% | ||
| 21 | Rhenman & Partners Asset Management AB | 105,255 | 2,035,000 | 0.67% | ||
| 22 | STATE STREET CORP | 98,859 | 1,914,000 | 0.63% | ||
| 23 | SABBY MANAGEMENT, LLC | 95,800 | 1,852,000 | 0.61% | ||
| 24 | BlackRock Institutional Trust Company, N.A. | 94,138 | 1,820,000 | 0.60% | ||
| 25 | Nicholas Investment Partners, LP | 92,288 | 1,784,000 | 0.59% | ||
| 26 | NORTHERN TRUST CORP | 90,979 | 1,758,000 | 0.58% | ||
| 27 | Zweig-DiMenna Associates LLC | 84,460 | 1,633,000 | 0.54% | ||
| 28 | Bank of New York Mellon Corp | 83,984 | 1,623,000 | 0.54% | ||
| 29 | LEVIN CAPITAL STRATEGIES, L.P. | 82,655 | 1,598,000 | 0.53% | ||
| 30 | Palo Alto Investors LP | 80,369 | 1,554,000 | 0.51% | ||
| 31 | DRIEHAUS CAPITAL MANAGEMENT LLC | 74,289 | 1,436,000 | 0.47% | ||
| 32 | HIGHLAND CAPITAL MANAGEMENT LP | 72,866 | 1,408,000 | 0.47% | ||
| 33 | PRINCIPAL FINANCIAL GROUP INC | 72,616 | 1,404,000 | 0.46% | ||
| 34 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 65,200 | 1,260,000 | 0.42% | ||
| 35 | GEODE CAPITAL MANAGEMENT, LLC | 63,131 | 1,220,000 | 0.40% | ||
| 36 | WALL STREET ASSOCIATES | 57,330 | 1,108,000 | 0.37% | ||
| 37 | COLUMBUS CIRCLE INVESTORS | 55,741 | 1,077,000 | 0.36% | ||
| 38 | TCW GROUP INC | 55,722 | 1,077,000 | 0.36% | ||
| 39 | Standard Investments LLC | 47,846 | 925,000 | 0.31% | ||
| 40 | BAMCO INC /NY/ | 43,000 | 831,000 | 0.27% | ||
| 41 | PDT Partners, LLC | 42,070 | 813,000 | 0.27% | ||
| 42 | Robert W. Baird & Co. Inc | 36,078 | 697,000 | 0.23% | SH | |
| 43 | Alyeska Investment Group, L.P. | 32,360 | 626,000 | 0.21% | ||
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 28,872 | 558,000 | 0.18% | ||
| 45 | CITADEL ADVISORS LLC | 27,554 | 533,000 | 0.18% | ||
| 46 | BlackRock Investment Management, LLC | 26,314 | 509,000 | 0.17% | ||
| 47 | State of New Jersey Common Pension Fund D | 26,000 | 503,000 | 0.17% | ||
| 48 | SECOR Capital Advisors, LP | 22,175 | 429,000 | 0.14% | ||
| 49 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 19,247 | 373,000 | 0.12% | ||
| 50 | Nationwide Fund Advisors | 19,150 | 370,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
