| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Essex Woodlands Management, Inc. | 4,592,047 | 146,854,000 | 22.41% | ||
| 2 | NQ HCIF GP, Ltd. | 3,096,650 | 99,031,000 | 15.11% | ||
| 3 | FRANKLIN RESOURCES INC | 3,066,887 | 98,079,000 | 14.97% | ||
| 4 | Bank of New York Mellon Corp | 1,840,141 | 58,848,000 | 8.98% | ||
| 5 | JPMORGAN CHASE & CO | 1,396,505 | 44,661,000 | 6.82% | ||
| 6 | Polar Capital LLP | 1,130,409 | 36,150,000 | 5.52% | ||
| 7 | BlackRock Fund Advisors | 720,999 | 23,058,000 | 3.52% | ||
| 8 | ArrowMark Colorado Holdings LLC | 552,972 | 17,684,000 | 2.70% | ||
| 9 | VANGUARD GROUP INC | 448,457 | 14,342,000 | 2.19% | ||
| 10 | WADDELL & REED FINANCIAL INC | 310,350 | 9,925,000 | 1.51% | ||
| 11 | GOLDMAN SACHS GROUP INC | 309,938 | 9,912,000 | 1.51% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 262,609 | 8,398,000 | 1.28% | ||
| 13 | Lombard Odier Asset Management (USA) Corp | 250,000 | 7,995,000 | 1.22% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 203,507 | 6,508,000 | 0.99% | ||
| 15 | LORD, ABBETT & CO. LLC | 201,366 | 6,439,000 | 0.98% | ||
| 16 | STATE STREET CORP | 193,221 | 6,185,000 | 0.94% | ||
| 17 | Rhenman & Partners Asset Management AB | 172,000 | 5,501,000 | 0.84% | ||
| 18 | RENAISSANCE TECHNOLOGIES LLC | 128,500 | 4,109,000 | 0.63% | ||
| 19 | WELLINGTON MANAGEMENT GROUP LLP | 108,622 | 3,474,000 | 0.53% | ||
| 20 | NORTHERN TRUST CORP | 106,423 | 3,404,000 | 0.52% | ||
| 21 | JENNISON ASSOCIATES LLC | 77,553 | 2,480,000 | 0.38% | ||
| 22 | DEUTSCHE BANK AG\ | 77,526 | 2,479,000 | 0.38% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 77,223 | 2,469,000 | 0.38% | ||
| 24 | PRINCIPAL FINANCIAL GROUP INC | 76,765 | 2,455,000 | 0.37% | ||
| 25 | LEVIN CAPITAL STRATEGIES, L.P. | 75,261 | 2,407,000 | 0.37% | ||
| 26 | ESSEX INVESTMENT MANAGEMENT CO LLC | 71,701 | 2,293,000 | 0.35% | ||
| 27 | MORGAN STANLEY | 59,420 | 1,900,000 | 0.29% | ||
| 28 | BlackRock Investment Management, LLC | 55,668 | 1,780,000 | 0.27% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 53,683 | 1,717,000 | 0.26% | ||
| 30 | FIL Ltd | 44,064 | 1,409,000 | 0.22% | ||
| 31 | D. E. Shaw & Co., Inc. | 41,772 | 1,336,000 | 0.20% | ||
| 32 | CREDIT SUISSE AG/ | 37,098 | 1,186,000 | 0.18% | ||
| 33 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 36,234 | 1,159,000 | 0.18% | ||
| 34 | BAIRD FINANCIAL GROUP, INC. | 34,181 | 1,093,000 | 0.17% | ||
| 35 | DRW Securities, LLC | 34,000 | 1,087,000 | 0.17% | ||
| 36 | Trexquant Investment LP | 29,900 | 956,000 | 0.15% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 29,084 | 930,000 | 0.14% | ||
| 38 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 28,574 | 914,000 | 0.14% | ||
| 39 | State of New Jersey Common Pension Fund D | 26,000 | 831,000 | 0.13% | ||
| 40 | ALPS ADVISORS INC | 23,738 | 759,000 | 0.12% | ||
| 41 | CITADEL ADVISORS LLC | 23,656 | 757,000 | 0.12% | ||
| 42 | TEACHERS ADVISORS, LLC | 22,897 | 732,000 | 0.11% | ||
| 43 | COLUMBUS CIRCLE INVESTORS | 21,223 | 679,000 | 0.10% | ||
| 44 | ProShare Advisors LLC | 21,106 | 675,000 | 0.10% | ||
| 45 | ALLIANCEBERNSTEIN L.P. | 19,900 | 636,000 | 0.10% | ||
| 46 | Swiss National Bank | 19,450 | 622,000 | 0.09% | ||
| 47 | ELLINGTON MANAGEMENT GROUP LLC | 19,100 | 611,000 | 0.09% | ||
| 48 | PDT Partners, LLC | 18,718 | 599,000 | 0.09% | ||
| 49 | NOTTINGHAM ADVISORS, INC. | 18,328 | 586,000 | 0.09% | ||
| 50 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 17,904 | 573,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
