| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Essex Woodlands Management, Inc. | 4,592,047 | 62,452,000 | 15.92% | ||
| 2 | JPMORGAN CHASE & CO | 3,327,022 | 45,247,000 | 11.53% | ||
| 3 | FRANKLIN RESOURCES INC | 3,166,536 | 43,065,000 | 10.98% | ||
| 4 | NQ HCIF GP, Ltd. | 3,096,650 | 42,114,000 | 10.73% | ||
| 5 | WELLINGTON MANAGEMENT GROUP LLP | 2,338,548 | 31,805,000 | 8.11% | ||
| 6 | Bank of New York Mellon Corp | 2,118,558 | 28,812,000 | 7.34% | ||
| 7 | ArrowMark Colorado Holdings LLC | 1,669,992 | 22,712,000 | 5.79% | ||
| 8 | BlackRock Fund Advisors | 1,194,355 | 16,243,000 | 4.14% | ||
| 9 | Polar Capital LLP | 1,168,542 | 15,891,000 | 4.05% | ||
| 10 | VANGUARD GROUP INC | 783,706 | 10,659,000 | 2.72% | ||
| 11 | CANADA PENSION PLAN INVESTMENT BOARD | 610,300 | 8,300,000 | 2.12% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 514,939 | 7,003,000 | 1.78% | ||
| 13 | STATE STREET CORP | 429,482 | 5,840,000 | 1.49% | ||
| 14 | GOLDMAN SACHS GROUP INC | 425,179 | 5,782,000 | 1.47% | ||
| 15 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 375,000 | 5,100,000 | 1.30% | ||
| 16 | WADDELL & REED FINANCIAL INC | 300,000 | 4,080,000 | 1.04% | ||
| 17 | PointState Capital LP | 250,000 | 3,400,000 | 0.87% | ||
| 18 | NORTHERN TRUST CORP | 231,794 | 3,152,000 | 0.80% | ||
| 19 | Rhenman & Partners Asset Management AB | 220,000 | 2,992,000 | 0.76% | ||
| 20 | SUFFOLK CAPITAL MANAGEMENT LLC | 158,812 | 2,160,000 | 0.55% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 143,457 | 1,951,000 | 0.50% | ||
| 22 | Iguana Healthcare Management, LLC | 100,000 | 1,360,000 | 0.35% | ||
| 23 | BAIRD FINANCIAL GROUP, INC. | 94,308 | 1,283,000 | 0.33% | ||
| 24 | MORGAN STANLEY | 90,037 | 1,225,000 | 0.31% | ||
| 25 | ESSEX INVESTMENT MANAGEMENT CO LLC | 81,701 | 1,111,000 | 0.28% | ||
| 26 | PRINCIPAL FINANCIAL GROUP INC | 79,967 | 1,087,000 | 0.28% | ||
| 27 | BlackRock Investment Management, LLC | 78,313 | 1,065,000 | 0.27% | ||
| 28 | VIVO CAPITAL, LLC | 77,373 | 1,052,000 | 0.27% | ||
| 29 | UNITED BANK | 77,177 | 1,050,000 | 0.27% | ||
| 30 | Tekla Capital Management LLC | 75,000 | 1,020,000 | 0.26% | ||
| 31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 66,263 | 902,000 | 0.23% | ||
| 32 | DRILL CRAIG A | 65,600 | 892,000 | 0.23% | ||
| 33 | TIAA CREF INVESTMENT MANAGEMENT LLC | 61,589 | 838,000 | 0.21% | ||
| 34 | JACOBS LEVY EQUITY MANAGEMENT, INC | 51,400 | 699,000 | 0.18% | ||
| 35 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 42,870 | 583,000 | 0.15% | ||
| 36 | ALPS ADVISORS INC | 39,990 | 544,000 | 0.14% | ||
| 37 | ALLIANCEBERNSTEIN L.P. | 35,300 | 480,000 | 0.12% | ||
| 38 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 33,761 | 459,000 | 0.12% | ||
| 39 | Nationwide Fund Advisors | 33,556 | 456,000 | 0.12% | ||
| 40 | TEACHERS ADVISORS, LLC | 32,072 | 436,000 | 0.11% | ||
| 41 | Swiss National Bank | 30,750 | 418,000 | 0.11% | ||
| 42 | TUDOR INVESTMENT CORP ET AL | 27,200 | 370,000 | 0.09% | ||
| 43 | State of New Jersey Common Pension Fund D | 26,000 | 354,000 | 0.09% | ||
| 44 | CREDIT SUISSE AG/ | 24,852 | 338,000 | 0.09% | ||
| 45 | ProShare Advisors LLC | 23,688 | 322,000 | 0.08% | ||
| 46 | Lombard Odier Asset Management (USA) Corp | 22,515 | 306,000 | 0.08% | ||
| 47 | DEUTSCHE BANK AG\ | 22,184 | 300,000 | 0.08% | ||
| 48 | GREAT POINT PARTNERS LLC | 21,665 | 295,000 | 0.08% | ||
| 49 | Janney Montgomery Scott LLC | 8,425 | 288,000 | 0.07% | ||
| 50 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 21,068 | 287,000 | 0.07% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
