| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,511,541 | 105,813,000 | 21.94% | ||
| 2 | BlackRock Finance, Inc. | 3,574,983 | 58,093,000 | 12.04% | ||
| 3 | VANGUARD GROUP INC | 2,741,887 | 44,556,000 | 9.24% | ||
| 4 | BB BIOTECH AG | 1,925,000 | 31,281,000 | 6.49% | ||
| 5 | WASATCH ADVISORS LP | 1,005,113 | 16,333,000 | 3.39% | ||
| 6 | HILLHOUSE INVESTMENT MANAGEMENT, LTD. | 1,000,000 | 16,250,000 | 3.37% | ||
| 7 | STATE STREET CORP | 909,597 | 14,786,000 | 3.07% | ||
| 8 | CLOUGH CAPITAL PARTNERS L P | 898,750 | 14,605,000 | 3.03% | ||
| 9 | CITADEL ADVISORS LLC | 800,527 | 13,009,000 | 2.70% | ||
| 10 | Rhenman & Partners Asset Management AB | 715,664 | 11,630,000 | 2.41% | ||
| 11 | BAKER BROS. ADVISORS LP | 609,166 | 9,899,000 | 2.05% | ||
| 12 | PRICE T ROWE ASSOCIATES INC /MD/ | 483,311 | 7,854,000 | 1.63% | ||
| 13 | DEUTSCHE BANK AG\ | 466,390 | 7,577,000 | 1.57% | ||
| 14 | MORGAN STANLEY | 431,823 | 7,017,000 | 1.45% | ||
| 15 | NORTHERN TRUST CORP | 412,864 | 6,710,000 | 1.39% | ||
| 16 | COLUMBUS CIRCLE INVESTORS | 380,911 | 6,190,000 | 1.28% | ||
| 17 | Sarissa Capital Management LP | 360,000 | 5,850,000 | 1.21% | ||
| 18 | MILLENNIUM MANAGEMENT LLC | 352,647 | 5,731,000 | 1.19% | ||
| 19 | SAMLYN CAPITAL, LLC | 338,500 | 5,501,000 | 1.14% | ||
| 20 | Numeric Investors LLC | 325,200 | 5,284,000 | 1.10% | ||
| 21 | RENAISSANCE TECHNOLOGIES LLC | 276,000 | 4,485,000 | 0.93% | ||
| 22 | NORGES BANK | 273,354 | 4,442,000 | 0.92% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 270,782 | 4,400,000 | 0.91% | ||
| 24 | DekaBank Deutsche Girozentrale | 239,200 | 3,889,000 | 0.81% | ||
| 25 | Candriam S.C.A. | 192,000 | 3,120,000 | 0.65% | ||
| 26 | Rock Springs Capital Management LP | 190,000 | 3,088,000 | 0.64% | ||
| 27 | C WorldWide Group Holding A/S | 187,823 | 3,052,000 | 0.63% | ||
| 28 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 161,458 | 2,623,000 | 0.54% | ||
| 29 | Ghost Tree Capital, LLC | 150,000 | 2,438,000 | 0.51% | ||
| 30 | Bank of New York Mellon Corp | 147,195 | 2,392,000 | 0.50% | ||
| 31 | TIAA CREF INVESTMENT MANAGEMENT LLC | 140,080 | 2,276,000 | 0.47% | ||
| 32 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 137,975 | 2,243,000 | 0.47% | ||
| 33 | GOLDMAN SACHS GROUP INC | 133,184 | 2,164,000 | 0.45% | ||
| 34 | PICTET ASSET MANAGEMENT LTD | 126,864 | 2,062,000 | 0.43% | ||
| 35 | DIMENSIONAL FUND ADVISORS LP | 124,622 | 2,025,000 | 0.42% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 107,200 | 1,742,000 | 0.36% | Put | |
| 37 | FIRST MIDWEST BANK TRUST DIVISION | 102,326 | 1,663,000 | 0.34% | ||
| 38 | A.R.T. Advisors, LLC | 101,200 | 1,644,000 | 0.34% | ||
| 39 | FRONTIER CAPITAL MANAGEMENT CO LLC | 98,759 | 1,605,000 | 0.33% | ||
| 40 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 92,971 | 1,511,000 | 0.31% | ||
| 41 | PDT Partners, LLC | 91,184 | 1,482,000 | 0.31% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 91,100 | 1,480,000 | 0.31% | Call | |
| 43 | WELLS FARGO & COMPANY/MN | 88,195 | 1,433,000 | 0.30% | ||
| 44 | FEDERATED HERMES, INC. | 85,807 | 1,394,000 | 0.29% | ||
| 45 | Weiss Multi-Strategy Advisers LLC | 80,000 | 1,300,000 | 0.27% | ||
| 46 | ALPINE WOODS CAPITAL INVESTORS, LLC | 73,944 | 1,202,000 | 0.25% | ||
| 47 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 67,565 | 1,098,000 | 0.23% | ||
| 48 | State of New Jersey Common Pension Fund D | 62,500 | 1,016,000 | 0.21% | ||
| 49 | TEACHERS ADVISORS, LLC | 58,377 | 949,000 | 0.20% | ||
| 50 | ALLIANCEBERNSTEIN L.P. | 55,410 | 900,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
