| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 2,380,074 | 44,079,000 | 29.40% | ||
| 2 | FMR LLC | 1,311,623 | 24,291,000 | 16.20% | ||
| 3 | ORBIMED ADVISORS LLC | 1,167,000 | 21,613,000 | 14.42% | ||
| 4 | FRANKLIN RESOURCES INC | 842,346 | 15,600,000 | 10.41% | ||
| 5 | QVT Financial LP | 507,184 | 8,579,000 | 5.72% | ||
| 6 | Artal Group S.A. | 250,000 | 4,630,000 | 3.09% | ||
| 7 | TANG CAPITAL MANAGEMENT LLC | 238,432 | 4,416,000 | 2.95% | ||
| 8 | VANGUARD GROUP INC | 216,016 | 4,001,000 | 2.67% | ||
| 9 | BlackRock Fund Advisors | 197,671 | 3,661,000 | 2.44% | ||
| 10 | Broadfin Capital, LLC | 184,756 | 3,422,000 | 2.28% | ||
| 11 | First Eagle Investment Management, LLC | 99,912 | 1,850,000 | 1.23% | ||
| 12 | DRIEHAUS CAPITAL MANAGEMENT LLC | 92,432 | 1,712,000 | 1.14% | ||
| 13 | JPMORGAN CHASE & CO | 88,800 | 1,645,000 | 1.10% | ||
| 14 | Candriam S.C.A. | 70,000 | 1,296,000 | 0.86% | ||
| 15 | STATE STREET CORP | 67,070 | 1,241,000 | 0.83% | ||
| 16 | NORTHERN TRUST CORP | 62,938 | 1,165,000 | 0.78% | ||
| 17 | BlackRock Institutional Trust Company, N.A. | 56,388 | 1,044,000 | 0.70% | ||
| 18 | MORGAN STANLEY | 34,736 | 643,000 | 0.43% | ||
| 19 | BAILARD, INC. | 34,000 | 630,000 | 0.42% | ||
| 20 | TIAA CREF INVESTMENT MANAGEMENT LLC | 27,309 | 506,000 | 0.34% | ||
| 21 | GOLDMAN SACHS GROUP INC | 27,295 | 506,000 | 0.34% | ||
| 22 | Integre Asset Management, LLC | 22,768 | 422,000 | 0.28% | ||
| 23 | Bank of New York Mellon Corp | 20,624 | 382,000 | 0.25% | ||
| 24 | BlackRock Investment Management, LLC | 20,509 | 380,000 | 0.25% | ||
| 25 | DEUTSCHE BANK AG\ | 20,104 | 372,000 | 0.25% | ||
| 26 | ROYAL BANK OF CANADA | 17,361 | 321,000 | 0.21% | ||
| 27 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 13,232 | 245,000 | 0.16% | ||
| 28 | UBS Group AG | 11,760 | 218,000 | 0.15% | ||
| 29 | Boulegeris Investments, Inc. | 11,075 | 205,000 | 0.14% | ||
| 30 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 10,500 | 195,000 | 0.13% | ||
| 31 | TEACHERS ADVISORS, LLC | 10,258 | 190,000 | 0.13% | ||
| 32 | Nationwide Fund Advisors | 5,383 | 100,000 | 0.07% | ||
| 33 | AMERICAN INTERNATIONAL GROUP, INC. | 4,511 | 83,544 | 0.06% | ||
| 34 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 3,076 | 57,000 | 0.04% | ||
| 35 | Financial Architects, Inc | 3,000 | 56,000 | 0.04% | ||
| 36 | BLACKROCK ADVISORS LLC | 2,702 | 50,000 | 0.03% | ||
| 37 | Tower Research Capital LLC (TRC) | 2,059 | 38,000 | 0.03% | ||
| 38 | CITIGROUP INC | 1,231 | 23,000 | 0.02% | ||
| 39 | WELLS FARGO & COMPANY/MN | 1,010 | 19,000 | 0.01% | ||
| 40 | BARCLAYS PLC | 583 | 10,000 | 0.01% | ||
| 41 | NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 400 | 7,000 | 0.00% | ||
| 42 | ALLIANCEBERNSTEIN L.P. | 400 | 7,000 | 0.00% | ||
| 43 | Creative Planning | 258 | 5,000 | 0.00% | ||
| 44 | B. Riley Wealth Management, Inc. | 82 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
