| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | AVIVA HOLDINGS LTD. | 2,880,702 | 14,980,000 | 17.79% | ||
| 2 | Avoro Capital Advisors LLC | 2,383,201 | 12,393,000 | 14.72% | ||
| 3 | BAKER BROS. ADVISORS LP | 2,269,198 | 11,800,000 | 14.02% | ||
| 4 | Broadfin Capital, LLC | 2,090,801 | 10,872,000 | 12.91% | ||
| 5 | BOXER CAPITAL, LLC | 1,037,994 | 5,398,000 | 6.41% | ||
| 6 | BlackRock Finance, Inc. | 885,598 | 4,606,000 | 5.47% | ||
| 7 | HILLHOUSE INVESTMENT MANAGEMENT, LTD. | 725,000 | 3,770,000 | 4.48% | ||
| 8 | VANGUARD GROUP INC | 685,115 | 3,562,000 | 4.23% | ||
| 9 | FRANKLIN RESOURCES INC | 377,646 | 1,964,000 | 2.33% | ||
| 10 | Alyeska Investment Group, L.P. | 251,988 | 1,310,000 | 1.56% | ||
| 11 | SABBY MANAGEMENT, LLC | 249,735 | 1,299,000 | 1.54% | ||
| 12 | STATE STREET CORP | 212,538 | 1,107,000 | 1.31% | ||
| 13 | Ghost Tree Capital, LLC | 172,184 | 895,000 | 1.06% | ||
| 14 | NORTHERN TRUST CORP | 172,034 | 894,000 | 1.06% | ||
| 15 | RENAISSANCE TECHNOLOGIES LLC | 164,302 | 854,000 | 1.01% | ||
| 16 | ROYCE & ASSOCIATES LP | 133,037 | 692,000 | 0.82% | ||
| 17 | DIMENSIONAL FUND ADVISORS LP | 130,186 | 677,000 | 0.80% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 118,988 | 618,000 | 0.73% | ||
| 19 | MILLENNIUM MANAGEMENT LLC | 117,664 | 612,000 | 0.73% | ||
| 20 | PANAGORA ASSET MANAGEMENT INC | 104,143 | 542,000 | 0.64% | ||
| 21 | Omega Advisors Inc. | 100,000 | 520,000 | 0.62% | ||
| 22 | MACQUARIE GROUP LTD | 80,000 | 416,000 | 0.49% | ||
| 23 | CUTLER GROUP LLC / CA | 68,213 | 354,000 | 0.42% | ||
| 24 | Bank of New York Mellon Corp | 63,004 | 328,000 | 0.39% | ||
| 25 | MORGAN STANLEY | 53,000 | 276,000 | 0.33% | ||
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 51,202 | 266,000 | 0.32% | ||
| 27 | Rhenman & Partners Asset Management AB | 50,000 | 260,000 | 0.31% | ||
| 28 | DEUTSCHE BANK AG\ | 50,324 | 260,000 | 0.31% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 49,479 | 257,000 | 0.31% | ||
| 30 | D. E. Shaw & Co., Inc. | 47,514 | 247,000 | 0.29% | ||
| 31 | Trexquant Investment LP | 42,879 | 223,000 | 0.26% | ||
| 32 | JPMORGAN CHASE & CO | 37,366 | 194,000 | 0.23% | ||
| 33 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 31,094 | 162,000 | 0.19% | ||
| 34 | AQR CAPITAL MANAGEMENT LLC | 26,464 | 138,000 | 0.16% | ||
| 35 | TEACHERS ADVISORS, LLC | 23,097 | 120,000 | 0.14% | ||
| 36 | UBS Group AG | 22,495 | 117,000 | 0.14% | ||
| 37 | ALLIANCEBERNSTEIN L.P. | 21,300 | 111,000 | 0.13% | ||
| 38 | Virtu KCG Holdings LLC | 20,306 | 106,000 | 0.13% | ||
| 39 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 19,648 | 103,000 | 0.12% | ||
| 40 | RHUMBLINE ADVISERS | 16,954 | 88,000 | 0.10% | ||
| 41 | Connor, Clark & Lunn Investment Management Ltd. | 15,800 | 82,000 | 0.10% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 15,000 | 78,000 | 0.09% | Put | |
| 43 | WELLS FARGO & COMPANY/MN | 14,224 | 74,000 | 0.09% | ||
| 44 | TFS CAPITAL LLC | 12,389 | 64,000 | 0.08% | ||
| 45 | NEW YORK STATE COMMON RETIREMENT FUND | 11,901 | 62,000 | 0.07% | ||
| 46 | RUSSELL INVESTMENTS GROUP, LTD. | 11,309 | 59,000 | 0.07% | ||
| 47 | GOLDMAN SACHS GROUP INC | 10,393 | 54,000 | 0.06% | ||
| 48 | BANK OF AMERICA CORP /DE/ | 8,548 | 44,000 | 0.05% | ||
| 49 | CUTLER GROUP LLC / CA | 18,800 | 43,000 | 0.05% | Call | |
| 50 | AMERICAN INTERNATIONAL GROUP, INC. | 7,928 | 41,000 | 0.05% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
