| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,433,672 | 300,103,000 | 9.04% | ||
| 2 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,350,000 | 292,790,000 | 8.82% | ||
| 3 | FMR LLC | 2,520,048 | 220,252,000 | 6.63% | ||
| 4 | VANGUARD GROUP INC | 2,474,644 | 216,284,000 | 6.51% | ||
| 5 | ORBIMED ADVISORS LLC | 2,425,735 | 212,009,000 | 6.38% | ||
| 6 | JANUS HENDERSON GROUP PLC | 1,857,631 | 162,302,000 | 4.89% | ||
| 7 | BlackRock Finance, Inc. | 1,830,342 | 159,973,000 | 4.82% | ||
| 8 | WELLINGTON MANAGEMENT GROUP LLP | 1,707,163 | 149,207,000 | 4.49% | ||
| 9 | PFM Health Sciences, LP | 1,682,158 | 147,021,000 | 4.43% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 1,455,361 | 127,199,000 | 3.83% | ||
| 11 | STATE STREET CORP | 1,215,354 | 106,225,000 | 3.20% | ||
| 12 | CITADEL ADVISORS LLC | 937,797 | 81,963,000 | 2.47% | ||
| 13 | Redmile Group, LLC | 860,456 | 75,204,000 | 2.26% | ||
| 14 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 772,100 | 67,482,000 | 2.03% | Put | |
| 15 | PERCEPTIVE ADVISORS LLC | 733,320 | 64,092,000 | 1.93% | ||
| 16 | PointState Capital LP | 605,360 | 52,908,000 | 1.59% | ||
| 17 | FRANKLIN RESOURCES INC | 573,619 | 50,134,000 | 1.51% | ||
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 512,900 | 44,827,000 | 1.35% | Call | |
| 19 | NORGES BANK | 501,322 | 43,815,000 | 1.32% | ||
| 20 | GOLDMAN SACHS GROUP INC | 474,717 | 41,491,000 | 1.25% | ||
| 21 | SCHRODER INVESTMENT MANAGEMENT GROUP | 379,734 | 32,942,000 | 0.99% | ||
| 22 | NORTHERN TRUST CORP | 347,665 | 30,386,000 | 0.92% | ||
| 23 | Bain Capital Public Equity Management, LLC | 338,994 | 29,628,000 | 0.89% | ||
| 24 | EMERALD ADVISERS, LLC | 317,680 | 27,765,000 | 0.84% | ||
| 25 | PFM Health Sciences, LP | 309,100 | 27,015,000 | 0.81% | Call | |
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 258,540 | 22,596,000 | 0.68% | ||
| 27 | EMERALD MUTUAL FUND ADVISERS TRUST | 248,038 | 21,679,000 | 0.65% | ||
| 28 | FARALLON CAPITAL MANAGEMENT LLC | 213,000 | 18,616,000 | 0.56% | ||
| 29 | FRED ALGER MANAGEMENT, LLC | 207,884 | 18,169,000 | 0.55% | ||
| 30 | Tekla Capital Management LLC | 202,537 | 17,702,000 | 0.53% | ||
| 31 | DEUTSCHE BANK AG\ | 200,354 | 17,509,000 | 0.53% | ||
| 32 | D. E. Shaw & Co., Inc. | 200,168 | 17,495,000 | 0.53% | ||
| 33 | Rock Springs Capital Management LP | 186,000 | 16,256,000 | 0.49% | ||
| 34 | AMERIPRISE FINANCIAL INC | 164,104 | 14,339,000 | 0.43% | ||
| 35 | TEACHERS ADVISORS, LLC | 152,898 | 13,363,000 | 0.40% | ||
| 36 | Ghost Tree Capital, LLC | 150,000 | 13,110,000 | 0.39% | ||
| 37 | HealthCor Management, L.P. | 150,000 | 13,110,000 | 0.39% | ||
| 38 | BANK OF AMERICA CORP /DE/ | 148,568 | 12,985,000 | 0.39% | ||
| 39 | SAMLYN CAPITAL, LLC | 147,000 | 12,847,000 | 0.39% | Call | |
| 40 | Bank of New York Mellon Corp | 136,297 | 11,912,000 | 0.36% | ||
| 41 | Point72 Asset Management, L.P. | 131,900 | 11,528,000 | 0.35% | ||
| 42 | MILLENNIUM MANAGEMENT LLC | 128,300 | 11,213,000 | 0.34% | Put | |
| 43 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 123,380 | 10,784,000 | 0.32% | ||
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 123,114 | 10,760,000 | 0.32% | ||
| 45 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 107,200 | 9,369,000 | 0.28% | ||
| 46 | DEERFIELD MANAGEMENT COMPANY, L.P. | 104,000 | 9,090,000 | 0.27% | Put | |
| 47 | Tourbillon Capital Partners, L.P. | 100,000 | 8,740,000 | 0.26% | ||
| 48 | BOXER CAPITAL, LLC | 100,000 | 8,740,000 | 0.26% | ||
| 49 | HBK INVESTMENTS L P | 93,993 | 8,215,000 | 0.25% | ||
| 50 | BARCLAYS PLC | 84,062 | 7,347,000 | 0.22% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
