| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,686,668 | 211,544,000 | 14.65% | ||
| 2 | FMR LLC | 3,540,729 | 131,715,000 | 9.12% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 2,539,350 | 94,464,000 | 6.54% | ||
| 4 | VANGUARD GROUP INC | 2,428,909 | 90,355,000 | 6.26% | ||
| 5 | ORBIMED ADVISORS LLC | 2,245,925 | 83,548,000 | 5.79% | ||
| 6 | JANUS HENDERSON INVESTORS US LLC | 2,209,599 | 82,195,000 | 5.69% | ||
| 7 | BlackRock Finance, Inc. | 1,743,418 | 64,856,000 | 4.49% | ||
| 8 | Redmile Group, LLC | 1,725,414 | 64,185,000 | 4.44% | ||
| 9 | STATE STREET CORP | 1,499,747 | 55,792,000 | 3.86% | ||
| 10 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,148,945 | 42,741,000 | 2.96% | ||
| 11 | PFM Health Sciences, LP | 1,065,356 | 39,631,000 | 2.74% | ||
| 12 | SCHRODER INVESTMENT MANAGEMENT GROUP | 803,926 | 30,147,000 | 2.09% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 805,005 | 29,946,000 | 2.07% | ||
| 14 | PointState Capital LP | 771,000 | 28,681,000 | 1.99% | ||
| 15 | Camber Capital Management LP | 650,000 | 24,180,000 | 1.67% | ||
| 16 | FARALLON CAPITAL MANAGEMENT LLC | 580,500 | 21,595,000 | 1.50% | ||
| 17 | CITADEL ADVISORS LLC | 526,659 | 19,592,000 | 1.36% | ||
| 18 | Tourbillon Capital Partners, L.P. | 456,097 | 16,967,000 | 1.17% | ||
| 19 | NORGES BANK | 392,879 | 14,615,000 | 1.01% | ||
| 20 | AMERIPRISE FINANCIAL INC | 384,035 | 14,286,000 | 0.99% | ||
| 21 | EMERALD ADVISERS, LLC | 379,289 | 14,110,000 | 0.98% | ||
| 22 | NORTHERN TRUST CORP | 334,508 | 12,444,000 | 0.86% | ||
| 23 | GOLDMAN SACHS GROUP INC | 316,081 | 11,758,000 | 0.81% | ||
| 24 | FRED ALGER MANAGEMENT, LLC | 297,414 | 11,064,000 | 0.77% | ||
| 25 | EMERALD MUTUAL FUND ADVISERS TRUST | 260,817 | 9,702,000 | 0.67% | ||
| 26 | Tekla Capital Management LLC | 260,200 | 9,679,000 | 0.67% | ||
| 27 | BB BIOTECH AG | 245,616 | 9,137,000 | 0.63% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 232,371 | 8,644,000 | 0.60% | ||
| 29 | Ghost Tree Capital, LLC | 225,000 | 8,370,000 | 0.58% | ||
| 30 | DEUTSCHE BANK AG\ | 207,047 | 7,701,000 | 0.53% | ||
| 31 | RENAISSANCE TECHNOLOGIES LLC | 206,500 | 7,682,000 | 0.53% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 200,200 | 7,447,000 | 0.52% | Call | |
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 193,900 | 7,213,000 | 0.50% | Put | |
| 34 | Sio Capital Management, LLC | 160,064 | 5,954,000 | 0.41% | ||
| 35 | BANK OF AMERICA CORP /DE/ | 158,170 | 5,884,000 | 0.41% | ||
| 36 | HBK INVESTMENTS L P | 156,597 | 5,825,000 | 0.40% | ||
| 37 | Candriam S.C.A. | 154,500 | 5,748,000 | 0.40% | ||
| 38 | FEDERATED HERMES, INC. | 152,500 | 5,673,000 | 0.39% | ||
| 39 | TEACHERS ADVISORS, LLC | 145,197 | 5,401,000 | 0.37% | ||
| 40 | Bank of New York Mellon Corp | 134,225 | 4,994,000 | 0.35% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 119,312 | 4,439,000 | 0.31% | ||
| 42 | D. E. Shaw & Co., Inc. | 106,309 | 3,955,000 | 0.27% | ||
| 43 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 104,900 | 3,902,000 | 0.27% | ||
| 44 | BOXER CAPITAL, LLC | 100,000 | 3,720,000 | 0.26% | ||
| 45 | TIAA CREF INVESTMENT MANAGEMENT LLC | 95,884 | 3,567,000 | 0.25% | ||
| 46 | Rock Springs Capital Management LP | 94,500 | 3,515,000 | 0.24% | ||
| 47 | MARSHALL WACE NORTH AMERICA, L.P. | 94,090 | 3,481,000 | 0.24% | ||
| 48 | MARSHALL WACE ASIA LTD | 94,090 | 3,481,000 | 0.24% | ||
| 49 | MILLENNIUM MANAGEMENT LLC | 89,000 | 3,311,000 | 0.23% | Put | |
| 50 | CAPITAL FUND MANAGEMENT S.A. | 87,755 | 3,264,000 | 0.23% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
