| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,686,668 | 169,406,000 | 17.75% | ||
| 2 | FMR LLC | 4,873,963 | 145,195,000 | 15.22% | ||
| 3 | ORBIMED ADVISORS LLC | 2,964,025 | 88,298,000 | 9.25% | ||
| 4 | JANUS HENDERSON INVESTORS US LLC | 2,540,331 | 75,675,000 | 7.93% | ||
| 5 | VANGUARD GROUP INC | 1,929,407 | 57,477,000 | 6.02% | ||
| 6 | PFM Health Sciences, LP | 1,471,879 | 43,847,000 | 4.60% | ||
| 7 | Point72 Asset Management, L.P. | 1,415,800 | 42,177,000 | 4.42% | ||
| 8 | STATE STREET CORP | 1,055,380 | 31,441,000 | 3.30% | ||
| 9 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,016,874 | 30,293,000 | 3.17% | ||
| 10 | Capital Research Global Investors | 676,600 | 20,156,000 | 2.11% | ||
| 11 | BlackRock Fund Advisors | 602,071 | 17,936,000 | 1.88% | ||
| 12 | Tourbillon Capital Partners, L.P. | 587,126 | 17,490,000 | 1.83% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 582,564 | 17,355,000 | 1.82% | ||
| 14 | CORNERSTONE CAPITAL MANAGEMENT LLC | 482,707 | 14,380,000 | 1.51% | ||
| 15 | EverPoint Asset Management, LLC | 450,000 | 13,406,000 | 1.40% | ||
| 16 | BB BIOTECH AG | 431,991 | 12,869,000 | 1.35% | ||
| 17 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 395,750 | 11,789,000 | 1.24% | ||
| 18 | WEATHERBIE CAPITAL, LLC | 280,985 | 8,371,000 | 0.88% | ||
| 19 | NORTHERN TRUST CORP | 272,695 | 8,124,000 | 0.85% | ||
| 20 | BANK OF AMERICA CORP /DE/ | 266,479 | 7,938,000 | 0.83% | ||
| 21 | Tekla Capital Management LLC | 260,200 | 7,751,000 | 0.81% | ||
| 22 | CLOUGH CAPITAL PARTNERS L P | 246,600 | 7,346,000 | 0.77% | ||
| 23 | JPMORGAN CHASE & CO | 231,875 | 6,907,000 | 0.72% | ||
| 24 | Asset Management One Co., Ltd. | 172,207 | 5,218,000 | 0.55% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 146,950 | 4,377,000 | 0.46% | ||
| 26 | PAULSON & CO. INC. | 145,800 | 4,343,000 | 0.46% | ||
| 27 | EATON VANCE MANAGEMENT | 142,000 | 4,230,000 | 0.44% | ||
| 28 | UBS Group AG | 141,970 | 4,229,000 | 0.44% | ||
| 29 | D. E. Shaw & Co., Inc. | 135,727 | 4,043,000 | 0.42% | ||
| 30 | GOLDMAN SACHS GROUP INC | 133,722 | 3,984,000 | 0.42% | ||
| 31 | MILLENNIUM MANAGEMENT LLC | 125,000 | 3,724,000 | 0.39% | Put | |
| 32 | NORGES BANK | 124,247 | 3,701,000 | 0.39% | ||
| 33 | TEACHERS ADVISORS, LLC | 121,192 | 3,610,000 | 0.38% | ||
| 34 | Bank of New York Mellon Corp | 111,918 | 3,333,000 | 0.35% | ||
| 35 | EMERALD ACQUISITION LTD. | 110,788 | 3,301,000 | 0.35% | ||
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 105,022 | 3,129,000 | 0.33% | ||
| 37 | DEUTSCHE BANK AG\ | 97,416 | 2,900,000 | 0.30% | ||
| 38 | Candriam S.C.A. | 92,000 | 2,741,000 | 0.29% | ||
| 39 | BlackRock Investment Management, LLC | 91,504 | 2,726,000 | 0.29% | ||
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 79,231 | 2,360,000 | 0.25% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 65,000 | 1,936,000 | 0.20% | Call | |
| 42 | CREDIT SUISSE AG/ | 60,589 | 1,805,000 | 0.19% | ||
| 43 | NEW YORK STATE COMMON RETIREMENT FUND | 57,300 | 1,707,000 | 0.18% | ||
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 52,500 | 1,564,000 | 0.16% | Put | |
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 51,775 | 1,542,000 | 0.16% | ||
| 46 | FEDERATED HERMES, INC. | 50,139 | 1,494,000 | 0.16% | ||
| 47 | MILLENNIUM MANAGEMENT LLC | 50,000 | 1,490,000 | 0.16% | ||
| 48 | ALLIANCEBERNSTEIN L.P. | 46,840 | 1,395,000 | 0.15% | ||
| 49 | Swiss National Bank | 45,130 | 1,344,000 | 0.14% | ||
| 50 | ORBIS ALLAN GRAY LTD | 43,854 | 1,306,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
