| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 7,990,572 | 58,171,000 | 36.49% | ||
| 2 | BlackRock Finance, Inc. | 2,155,345 | 15,692,000 | 9.84% | ||
| 3 | FRANKLIN RESOURCES INC | 2,131,997 | 15,521,000 | 9.74% | ||
| 4 | WASATCH ADVISORS LP | 2,045,399 | 14,891,000 | 9.34% | ||
| 5 | VANGUARD GROUP INC | 1,198,730 | 8,727,000 | 5.48% | ||
| 6 | ACADIAN ASSET MANAGEMENT LLC | 853,718 | 6,216,000 | 3.90% | ||
| 7 | RENAISSANCE TECHNOLOGIES LLC | 616,581 | 4,489,000 | 2.82% | ||
| 8 | Artal Group S.A. | 546,278 | 3,977,000 | 2.50% | ||
| 9 | STATE STREET CORP | 401,192 | 2,919,000 | 1.83% | ||
| 10 | D. E. Shaw & Co., Inc. | 263,821 | 1,920,000 | 1.20% | ||
| 11 | NORTHERN TRUST CORP | 252,739 | 1,840,000 | 1.15% | ||
| 12 | Invesco Ltd. | 245,048 | 1,784,000 | 1.12% | ||
| 13 | OXFORD ASSET MANAGEMENT LLP | 215,681 | 1,570,000 | 0.98% | ||
| 14 | GEODE CAPITAL MANAGEMENT, LLC | 196,708 | 1,432,000 | 0.90% | ||
| 15 | DEUTSCHE BANK AG\ | 196,471 | 1,429,000 | 0.90% | ||
| 16 | ALLIANCEBERNSTEIN L.P. | 180,087 | 1,311,000 | 0.82% | ||
| 17 | P.A.W. CAPITAL CORP | 160,000 | 1,165,000 | 0.73% | ||
| 18 | PANAGORA ASSET MANAGEMENT INC | 153,808 | 1,120,000 | 0.70% | ||
| 19 | MILLENNIUM MANAGEMENT LLC | 153,248 | 1,116,000 | 0.70% | ||
| 20 | TIAA CREF INVESTMENT MANAGEMENT LLC | 128,546 | 936,000 | 0.59% | ||
| 21 | MORGAN STANLEY | 123,171 | 896,000 | 0.56% | ||
| 22 | THRIVENT FINANCIAL FOR LUTHERANS | 117,037 | 852,000 | 0.53% | ||
| 23 | BANK OF AMERICA CORP /DE/ | 113,121 | 824,000 | 0.52% | ||
| 24 | Bank of New York Mellon Corp | 107,625 | 784,000 | 0.49% | ||
| 25 | FEDERATED HERMES, INC. | 104,831 | 763,000 | 0.48% | ||
| 26 | JACOBS LEVY EQUITY MANAGEMENT, INC | 95,921 | 698,000 | 0.44% | ||
| 27 | ADAMS DIVERSIFIED EQUITY FUND, INC. | 87,900 | 640,000 | 0.40% | ||
| 28 | GOLDMAN SACHS GROUP INC | 79,299 | 577,000 | 0.36% | ||
| 29 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 77,396 | 563,000 | 0.35% | ||
| 30 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 71,142 | 517,000 | 0.32% | ||
| 31 | PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 69,613 | 507,000 | 0.32% | ||
| 32 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 62,800 | 457,000 | 0.29% | ||
| 33 | KEYBANK NATIONAL ASSOCIATION/OH | 54,982 | 400,000 | 0.25% | ||
| 34 | STRS OHIO | 52,600 | 382,000 | 0.24% | ||
| 35 | BAKER BROS. ADVISORS LP | 49,064 | 357,000 | 0.22% | ||
| 36 | EAGLE GLOBAL ADVISORS LLC | 46,330 | 337,000 | 0.21% | ||
| 37 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 46,240 | 337,000 | 0.21% | ||
| 38 | SMITH ASSET MANAGEMENT GROUP LP | 42,750 | 311,000 | 0.20% | ||
| 39 | ALPS ADVISORS INC | 41,127 | 299,000 | 0.19% | ||
| 40 | AMERICAN CENTURY COMPANIES INC | 40,744 | 297,000 | 0.19% | ||
| 41 | TEACHERS ADVISORS, LLC | 40,288 | 293,000 | 0.18% | ||
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 32,000 | 233,000 | 0.15% | ||
| 43 | PUTNAM INVESTMENTS LLC | 29,800 | 217,000 | 0.14% | ||
| 44 | RHUMBLINE ADVISERS | 29,343 | 214,000 | 0.13% | ||
| 45 | ProShare Advisors LLC | 28,164 | 205,000 | 0.13% | ||
| 46 | NEW YORK STATE COMMON RETIREMENT FUND | 25,701 | 187,000 | 0.12% | ||
| 47 | CITADEL ADVISORS LLC | 24,088 | 175,000 | 0.11% | ||
| 48 | WELLS FARGO & COMPANY/MN | 22,866 | 167,000 | 0.10% | ||
| 49 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 19,662 | 144,000 | 0.09% | ||
| 50 | Nationwide Fund Advisors | 13,828 | 101,000 | 0.06% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
