| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 7,990,572 | 58,171,000 | 33.60% | ||
| 2 | BlackRock Finance, Inc. | 2,155,345 | 15,692,000 | 9.06% | ||
| 3 | FRANKLIN RESOURCES INC | 2,131,997 | 15,521,000 | 8.97% | ||
| 4 | WASATCH ADVISORS LP | 2,045,399 | 14,891,000 | 8.60% | ||
| 5 | VANGUARD GROUP INC | 1,198,730 | 8,727,000 | 5.04% | ||
| 6 | ACADIAN ASSET MANAGEMENT LLC | 853,718 | 6,216,000 | 3.59% | ||
| 7 | RENAISSANCE TECHNOLOGIES LLC | 616,581 | 4,489,000 | 2.59% | ||
| 8 | Nantahala Capital Management, LLC | 605,353 | 4,407,000 | 2.55% | ||
| 9 | Artal Group S.A. | 546,278 | 3,977,000 | 2.30% | ||
| 10 | STATE STREET CORP | 401,192 | 2,919,000 | 1.69% | ||
| 11 | Sio Capital Management, LLC | 294,150 | 2,141,000 | 1.24% | ||
| 12 | D. E. Shaw & Co., Inc. | 263,821 | 1,920,000 | 1.11% | ||
| 13 | NORTHERN TRUST CORP | 252,739 | 1,840,000 | 1.06% | ||
| 14 | Iguana Healthcare Management, LLC | 250,000 | 1,820,000 | 1.05% | ||
| 15 | Invesco Ltd. | 245,048 | 1,784,000 | 1.03% | ||
| 16 | OXFORD ASSET MANAGEMENT LLP | 215,681 | 1,570,000 | 0.91% | ||
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 196,708 | 1,432,000 | 0.83% | ||
| 18 | DEUTSCHE BANK AG\ | 196,471 | 1,429,000 | 0.83% | ||
| 19 | ALLIANCEBERNSTEIN L.P. | 180,087 | 1,311,000 | 0.76% | ||
| 20 | P.A.W. CAPITAL CORP | 160,000 | 1,165,000 | 0.67% | ||
| 21 | PANAGORA ASSET MANAGEMENT INC | 153,808 | 1,120,000 | 0.65% | ||
| 22 | MILLENNIUM MANAGEMENT LLC | 153,248 | 1,116,000 | 0.64% | ||
| 23 | Spark Investment Management LLC | 144,300 | 1,050,000 | 0.61% | ||
| 24 | TIAA CREF INVESTMENT MANAGEMENT LLC | 128,546 | 936,000 | 0.54% | ||
| 25 | MORGAN STANLEY | 123,171 | 896,000 | 0.52% | ||
| 26 | EcoR1 Capital, LLC | 118,000 | 859,000 | 0.50% | ||
| 27 | THRIVENT FINANCIAL FOR LUTHERANS | 117,037 | 852,000 | 0.49% | ||
| 28 | BANK OF AMERICA CORP /DE/ | 113,121 | 824,000 | 0.48% | ||
| 29 | Bank of New York Mellon Corp | 107,625 | 784,000 | 0.45% | ||
| 30 | FEDERATED HERMES, INC. | 104,831 | 763,000 | 0.44% | ||
| 31 | JACOBS LEVY EQUITY MANAGEMENT, INC | 95,921 | 698,000 | 0.40% | ||
| 32 | RUSSELL INVESTMENTS GROUP, LTD. | 94,165 | 686,000 | 0.40% | ||
| 33 | ADAMS DIVERSIFIED EQUITY FUND, INC. | 87,900 | 640,000 | 0.37% | ||
| 34 | GOLDMAN SACHS GROUP INC | 79,299 | 577,000 | 0.33% | ||
| 35 | CITY FINANCIAL INVESTMENT CO LTD | 77,788 | 566,000 | 0.33% | ||
| 36 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 77,396 | 563,000 | 0.33% | ||
| 37 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 71,142 | 517,000 | 0.30% | ||
| 38 | PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 69,613 | 507,000 | 0.29% | ||
| 39 | Connor, Clark & Lunn Investment Management Ltd. | 69,450 | 506,000 | 0.29% | ||
| 40 | Piermont Capital Management Inc. | 66,498 | 484,000 | 0.28% | ||
| 41 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 62,800 | 457,000 | 0.26% | ||
| 42 | KEYBANK NATIONAL ASSOCIATION/OH | 54,982 | 400,000 | 0.23% | ||
| 43 | BANQUE PICTET & CIE SA | 54,178 | 394,000 | 0.23% | ||
| 44 | STRS OHIO | 52,600 | 382,000 | 0.22% | ||
| 45 | BAKER BROS. ADVISORS LP | 49,064 | 357,000 | 0.21% | ||
| 46 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 46,240 | 337,000 | 0.19% | ||
| 47 | EAGLE GLOBAL ADVISORS LLC | 46,330 | 337,000 | 0.19% | ||
| 48 | SMITH ASSET MANAGEMENT GROUP LP | 42,750 | 311,000 | 0.18% | ||
| 49 | ALPS ADVISORS INC | 41,127 | 299,000 | 0.17% | ||
| 50 | AMERICAN CENTURY COMPANIES INC | 40,744 | 297,000 | 0.17% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
