| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,979,429 | 44,529,000 | 21.71% | ||
| 2 | Redmile Group, LLC | 4,325,055 | 27,594,000 | 13.45% | ||
| 3 | BlackRock Finance, Inc. | 2,763,830 | 17,632,000 | 8.60% | ||
| 4 | VANGUARD GROUP INC | 1,848,257 | 11,792,000 | 5.75% | ||
| 5 | Numeric Investors LLC | 1,219,931 | 7,783,000 | 3.79% | ||
| 6 | Opaleye Management Inc. | 1,215,000 | 7,751,000 | 3.78% | ||
| 7 | ArrowMark Colorado Holdings LLC | 1,207,916 | 7,707,000 | 3.76% | ||
| 8 | DIMENSIONAL FUND ADVISORS LP | 1,043,336 | 6,656,000 | 3.25% | ||
| 9 | STATE STREET CORP | 772,336 | 4,930,000 | 2.40% | ||
| 10 | NORTHERN TRUST CORP | 631,105 | 4,027,000 | 1.96% | ||
| 11 | MORGAN STANLEY | 618,074 | 3,944,000 | 1.92% | ||
| 12 | D. E. Shaw & Co., Inc. | 596,602 | 3,806,000 | 1.86% | ||
| 13 | Artal Group S.A. | 500,000 | 3,190,000 | 1.56% | ||
| 14 | JPMORGAN CHASE & CO | 480,115 | 3,064,000 | 1.49% | ||
| 15 | Aisling Capital LLC | 472,943 | 3,017,000 | 1.47% | ||
| 16 | PANAGORA ASSET MANAGEMENT INC | 417,401 | 2,663,000 | 1.30% | ||
| 17 | Rhenman & Partners Asset Management AB | 400,000 | 2,552,000 | 1.24% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 341,238 | 2,177,000 | 1.06% | ||
| 19 | RENAISSANCE TECHNOLOGIES LLC | 309,609 | 1,975,000 | 0.96% | ||
| 20 | PRESCOTT GROUP CAPITAL MANAGEMENT, L.L.C. | 304,771 | 1,944,000 | 0.95% | ||
| 21 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 282,948 | 1,805,000 | 0.88% | ||
| 22 | Bank of New York Mellon Corp | 245,080 | 1,564,000 | 0.76% | ||
| 23 | QS Investors, LLC | 226,678 | 1,446,000 | 0.70% | ||
| 24 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 224,714 | 1,433,000 | 0.70% | ||
| 25 | TWO SIGMA INVESTMENTS, LP | 211,260 | 1,348,000 | 0.66% | ||
| 26 | PRUDENTIAL FINANCIAL INC | 207,740 | 1,325,000 | 0.65% | ||
| 27 | Parallax Volatility Advisers, L.P. | 200,000 | 1,276,000 | 0.62% | Call | |
| 28 | ACADIAN ASSET MANAGEMENT LLC | 198,752 | 1,269,000 | 0.62% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 196,708 | 1,255,000 | 0.61% | ||
| 30 | DEUTSCHE BANK AG\ | 188,888 | 1,204,000 | 0.59% | ||
| 31 | 683 Capital Management, LLC | 160,000 | 1,021,000 | 0.50% | ||
| 32 | BARCLAYS PLC | 152,175 | 971,000 | 0.47% | ||
| 33 | FIRST QUADRANT LLC/CA | 147,853 | 943,000 | 0.46% | ||
| 34 | PRICE T ROWE ASSOCIATES INC /MD/ | 139,427 | 890,000 | 0.43% | ||
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 133,921 | 855,000 | 0.42% | ||
| 36 | GSA CAPITAL PARTNERS LLP | 128,767 | 822,000 | 0.40% | ||
| 37 | CITADEL ADVISORS LLC | 123,269 | 786,000 | 0.38% | ||
| 38 | VICTORY CAPITAL MANAGEMENT INC | 121,644 | 776,000 | 0.38% | ||
| 39 | BAKER BROS. ADVISORS LP | 115,216 | 735,000 | 0.36% | ||
| 40 | TFS CAPITAL LLC | 107,270 | 684,000 | 0.33% | ||
| 41 | Connor, Clark & Lunn Investment Management Ltd. | 104,825 | 669,000 | 0.33% | ||
| 42 | Sessa Capital IM, L.P. | 103,701 | 662,000 | 0.32% | ||
| 43 | Invesco Ltd. | 101,749 | 649,000 | 0.32% | ||
| 44 | MILLENNIUM MANAGEMENT LLC | 87,995 | 561,000 | 0.27% | ||
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 84,116 | 537,000 | 0.26% | ||
| 46 | Granite Investment Partners, LLC | 83,573 | 534,000 | 0.26% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 82,400 | 526,000 | 0.26% | Call | |
| 48 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 77,200 | 493,000 | 0.24% | ||
| 49 | FT OPTIONS LLC | 75,239 | 480,000 | 0.23% | ||
| 50 | TEACHERS ADVISORS, LLC | 69,818 | 445,000 | 0.22% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
