| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FRANKLIN RESOURCES INC | 6,076,879 | 19,689,000 | 22.83% | ||
| 2 | FMR LLC | 4,346,785 | 14,084,000 | 16.33% | ||
| 3 | EcoR1 Capital, LLC | 2,537,026 | 8,220,000 | 9.53% | ||
| 4 | Polaris Venture Management Co. V, L.L.C. | 2,473,186 | 8,013,000 | 9.29% | ||
| 5 | BlackRock Finance, Inc. | 1,658,727 | 5,375,000 | 6.23% | ||
| 6 | Redmile Group, LLC | 1,419,058 | 4,598,000 | 5.33% | ||
| 7 | VANGUARD GROUP INC | 1,264,281 | 4,096,000 | 4.75% | ||
| 8 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 1,150,947 | 3,729,000 | 4.32% | ||
| 9 | MORGAN STANLEY | 633,944 | 2,054,000 | 2.38% | ||
| 10 | 683 Capital Management, LLC | 588,237 | 1,906,000 | 2.21% | ||
| 11 | CASDIN CAPITAL, LLC | 550,000 | 1,782,000 | 2.07% | ||
| 12 | STATE STREET CORP | 443,462 | 1,437,000 | 1.67% | ||
| 13 | BVF INC/IL | 391,386 | 1,268,000 | 1.47% | ||
| 14 | NORTHERN TRUST CORP | 368,208 | 1,193,000 | 1.38% | ||
| 15 | RENAISSANCE TECHNOLOGIES LLC | 308,800 | 1,001,000 | 1.16% | ||
| 16 | WELLS FARGO & COMPANY/MN | 253,063 | 820,000 | 0.95% | ||
| 17 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 250,000 | 810,000 | 0.94% | ||
| 18 | Telemetry Investments, L.L.C. | 225,700 | 731,000 | 0.85% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 177,082 | 573,000 | 0.66% | ||
| 20 | Bank of New York Mellon Corp | 157,546 | 511,000 | 0.59% | ||
| 21 | TIAA CREF INVESTMENT MANAGEMENT LLC | 115,275 | 373,000 | 0.43% | ||
| 22 | GOLDMAN SACHS GROUP INC | 111,775 | 362,000 | 0.42% | ||
| 23 | ALGERT GLOBAL LLC | 102,169 | 331,000 | 0.38% | ||
| 24 | OXFORD ASSET MANAGEMENT LLP | 93,583 | 303,000 | 0.35% | ||
| 25 | TEACHERS ADVISORS, LLC | 71,990 | 233,000 | 0.27% | ||
| 26 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 67,500 | 219,000 | 0.25% | ||
| 27 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 66,000 | 214,000 | 0.25% | ||
| 28 | Connor, Clark & Lunn Investment Management Ltd. | 63,500 | 206,000 | 0.24% | ||
| 29 | MILLENNIUM MANAGEMENT LLC | 53,614 | 174,000 | 0.20% | ||
| 30 | JACOBS LEVY EQUITY MANAGEMENT, INC | 50,004 | 162,000 | 0.19% | ||
| 31 | Neuberger Berman Group LLC | 49,700 | 161,000 | 0.19% | ||
| 32 | UBS Group AG | 43,625 | 141,000 | 0.16% | ||
| 33 | DEUTSCHE BANK AG\ | 43,925 | 141,000 | 0.16% | ||
| 34 | RHUMBLINE ADVISERS | 40,967 | 133,000 | 0.15% | ||
| 35 | NEW YORK STATE COMMON RETIREMENT FUND | 40,500 | 131,000 | 0.15% | ||
| 36 | TFS CAPITAL LLC | 34,107 | 111,000 | 0.13% | ||
| 37 | STATE OF WISCONSIN INVESTMENT BOARD | 30,000 | 97,000 | 0.11% | ||
| 38 | PANAGORA ASSET MANAGEMENT INC | 29,510 | 96,000 | 0.11% | ||
| 39 | Squarepoint Ops LLC | 28,900 | 94,000 | 0.11% | ||
| 40 | Creative Planning | 28,000 | 91,000 | 0.11% | ||
| 41 | AMERICAN INTERNATIONAL GROUP, INC. | 23,650 | 77,000 | 0.09% | ||
| 42 | DIMENSIONAL FUND ADVISORS LP | 23,500 | 76,000 | 0.09% | ||
| 43 | Nationwide Fund Advisors | 21,117 | 68,000 | 0.08% | ||
| 44 | JPMORGAN CHASE & CO | 21,010 | 68,000 | 0.08% | ||
| 45 | Invesco Ltd. | 20,736 | 67,000 | 0.08% | ||
| 46 | BARCLAYS PLC | 11,668 | 38,000 | 0.04% | ||
| 47 | STRS OHIO | 11,100 | 35,000 | 0.04% | ||
| 48 | GUGGENHEIM CAPITAL LLC | 10,300 | 33,000 | 0.04% | ||
| 49 | Community Bank, N.A. | 6,500 | 21,000 | 0.02% | ||
| 50 | Legal & General Group Plc | 5,627 | 18,000 | 0.02% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
