| # | % | |||||
|---|---|---|---|---|---|---|
| 101 | TIAA CREF INVESTMENT MANAGEMENT LLC | 294,036 | 4,734,000 | 0.42% | ||
| 102 | Rock Springs Capital Management LP | 300,000 | 4,830,000 | 0.43% | ||
| 103 | VHCP Management, LLC | 303,503 | 4,886,000 | 0.43% | ||
| 104 | AXA S.A. | 307,468 | 4,950,000 | 0.44% | ||
| 105 | Bank of New York Mellon Corp | 366,996 | 5,909,000 | 0.52% | ||
| 106 | GEODE CAPITAL MANAGEMENT, LLC | 405,729 | 6,532,000 | 0.57% | ||
| 107 | Tekla Capital Management LLC | 427,790 | 6,887,000 | 0.61% | ||
| 108 | AMUNDI ASSET MANAGEMENT US, INC. | 434,514 | 6,996,000 | 0.62% | ||
| 109 | BAKER BROS. ADVISORS LP | 447,874 | 7,211,000 | 0.63% | ||
| 110 | AQR CAPITAL MANAGEMENT LLC | 454,964 | 7,325,000 | 0.64% | ||
| 111 | TURNER INVESTMENTS LLC | 544,770 | 8,770,000 | 0.77% | ||
| 112 | WELLINGTON MANAGEMENT GROUP LLP | 566,643 | 9,123,000 | 0.80% | ||
| 113 | GREAT POINT PARTNERS LLC | 620,000 | 9,982,000 | 0.88% | ||
| 114 | THRIVENT FINANCIAL FOR LUTHERANS | 671,990 | 10,819,000 | 0.95% | ||
| 115 | JANUS HENDERSON INVESTORS US LLC | 673,664 | 10,846,000 | 0.95% | ||
| 116 | DEUTSCHE BANK AG\ | 736,883 | 11,861,000 | 1.04% | ||
| 117 | GOLDMAN SACHS GROUP INC | 741,570 | 11,939,000 | 1.05% | ||
| 118 | LOOMIS SAYLES & CO L P | 869,364 | 13,996,000 | 1.23% | ||
| 119 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 889,898 | 14,327,000 | 1.26% | ||
| 120 | NORTHERN TRUST CORP | 996,182 | 16,039,000 | 1.41% | ||
| 121 | BLACKROCK ADVISORS LLC | 1,064,000 | 17,131,000 | 1.51% | ||
| 122 | Capital World Investors | 1,150,200 | 18,518,000 | 1.63% | ||
| 123 | RA CAPITAL MANAGEMENT, L.P. | 1,169,084 | 18,822,000 | 1.66% | ||
| 124 | ArrowMark Colorado Holdings LLC | 1,256,421 | 20,228,000 | 1.78% | ||
| 125 | Visium Asset Management, LP | 2,000,935 | 32,216,000 | 2.84% | ||
| 126 | BlackRock Institutional Trust Company, N.A. | 2,083,849 | 33,550,000 | 2.95% | ||
| 127 | FRANKLIN RESOURCES INC | 2,204,200 | 35,488,000 | 3.12% | ||
| 128 | VANGUARD GROUP INC | 2,221,142 | 35,760,000 | 3.15% | ||
| 129 | STATE STREET CORP | 2,243,649 | 36,124,000 | 3.18% | ||
| 130 | BlackRock Fund Advisors | 2,808,536 | 45,217,000 | 3.98% | ||
| 131 | BB BIOTECH AG | 2,996,552 | 48,244,000 | 4.25% | ||
| 132 | PERCEPTIVE ADVISORS LLC | 4,619,367 | 74,372,000 | 6.54% | ||
| 133 | ORBIMED ADVISORS LLC | 5,451,000 | 87,761,000 | 7.72% | ||
| 134 | PRICE T ROWE ASSOCIATES INC /MD/ | 10,256,939 | 165,137,000 | 14.53% | ||
| 135 | FMR LLC | 11,298,586 | 181,907,000 | 16.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
